WITHDRAWN: Welcome to this special issue of AJPS on Inhalation drug delivery

Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve rational site-targeting, or facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of the presence of the drug in the body. Drug delivery is often approached through a drug's chemical formulation, medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form development and selection of route of administration; the latter sometimes even being considered part of the definition. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and adherence. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed stemming from the inventions conceived and developed within academic institutions. Many have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases. This Special Issue serves to highlight the progress of drug delivery within Canada. We invited articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

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Polymer Clay Nano-Composites

Polymers ◽

10.3390/polym11091445 ◽

2019 ◽

Vol 11 (9) ◽

pp. 1445

Author(s):

Stefano Leporatti

Keyword(s):

Drug Delivery ◽

Composite Materials ◽

Polymer Composite ◽

State Of The Art ◽

Environmental Water ◽

Water Remediation ◽

Nano Composites ◽

Special Issue ◽

Current State ◽

Exciting Area

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

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Paediatric Formulation: Design and Development

International Journal of Molecular Sciences ◽

10.3390/ijms21197118 ◽

2020 ◽

Vol 21 (19) ◽

pp. 7118

Author(s):

Antonio Lopalco ◽

Nunzio Denora

Keyword(s):

Drug Delivery ◽

Patient Population ◽

State Of The Art ◽

Original Research ◽

Special Issue ◽

Formulation Development ◽

Design And Development ◽

Formulation Design ◽

Age Appropriate ◽

Paediatric Formulation

The development of medicines designed for children can be challenging since this distinct patient population requires specific needs. A formulation designed for paediatric patients must consider the following aspects: patient population variability; dose flexibility; route of administration; patient compliance; drug and excipient tolerability. The purpose of this Special Issue entitled “Paediatric Formulation: Design and Development” is to provide an update on both state-of-the-art methodology and operational challenges in the design and development of paediatric formulations. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. This editorial, briefly, summarizes the objects of nine original research and review papers published in this Special Issue.

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Transmucosal Absorption Enhancers in the Drug Delivery Field

Pharmaceutics ◽

10.3390/pharmaceutics11070339 ◽

2019 ◽

Vol 11 (7) ◽

pp. 339 ◽

Cited By ~ 7

Author(s):

Maher ◽

Casettari ◽

Illum

Keyword(s):

Drug Delivery ◽

Clinical Trials ◽

Drug Delivery Systems ◽

Permeation Enhancer ◽

Special Issue ◽

Permeation Enhancers ◽

Absorption Enhancers ◽

Chemical Permeation Enhancers ◽

Epithelial Barriers ◽

Chemical Permeation

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.

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