scholarly journals Paediatric Formulation: Design and Development

2020 ◽  
Vol 21 (19) ◽  
pp. 7118
Author(s):  
Antonio Lopalco ◽  
Nunzio Denora
Keyword(s):  
Drug Delivery ◽  
Patient Population ◽  
State Of The Art ◽  
Original Research ◽  
Special Issue ◽  
Formulation Development ◽  
Design And Development ◽  
Formulation Design ◽  
Age Appropriate ◽  
Paediatric Formulation

The development of medicines designed for children can be challenging since this distinct patient population requires specific needs. A formulation designed for paediatric patients must consider the following aspects: patient population variability; dose flexibility; route of administration; patient compliance; drug and excipient tolerability. The purpose of this Special Issue entitled “Paediatric Formulation: Design and Development” is to provide an update on both state-of-the-art methodology and operational challenges in the design and development of paediatric formulations. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients. This editorial, briefly, summarizes the objects of nine original research and review papers published in this Special Issue.

scholarly journals Drug Delivery Technology Development in Canada

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 541
Author(s):  
Wasan ◽  
Badea
Keyword(s):  
Drug Delivery ◽  
Technology Development ◽  
The Body ◽  
Special Issue ◽  
Academic Institutions ◽  
Formulation Development ◽  
Drug Release Profile ◽  
History Of ◽  
Biotechnology Companies ◽  
Site Targeting

Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. It may involve rational site-targeting, or facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of the presence of the drug in the body. Drug delivery is often approached through a drug's chemical formulation, medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form development and selection of route of administration; the latter sometimes even being considered part of the definition. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and adherence. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed stemming from the inventions conceived and developed within academic institutions. Many have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases.  This Special Issue serves to highlight the progress of drug delivery within Canada. We invited articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

scholarly journals Polymer Clay Nano-Composites

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1445
Author(s):  
Stefano Leporatti
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Polymer Composite ◽  
State Of The Art ◽  
Environmental Water ◽  
Water Remediation ◽  
Nano Composites ◽  
Special Issue ◽  
Current State ◽  
Exciting Area

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

scholarly journals Path towards efficient paediatric formulation development based on partnering with clinical pharmacologists and clinicians, a c4c expert group White paper.

2021 ◽  
Author(s):  
Jennifer Walsh ◽  
Daniel Schaufelberger ◽  
Sonia Lurian ◽  
Sandra Klein ◽  
Hannah Batchelor ◽  
...  
Keyword(s):  
Decision Making ◽  
Age Groups ◽  
White Paper ◽  
Formulation Development ◽  
Effective Age ◽  
New Chemical Entities ◽  
Dosing Regimens ◽  
Post Marketing ◽  
Age Appropriate ◽  
Paediatric Formulation

Improved global access to novel age-appropriate formulations for paediatric subsets, either of new chemical entities or existing drugs, is a priority to ensure that medicines meet the needs of these patients. However, despite regulatory incentives, the introduction to the market of paediatric formulations still lags behind adult products. This is mainly caused by additional complexities associated with the development of acceptable age-appropriate paediatric medicines. This position paper proposes the use of a paediatric Quality Target Product Profile (pQTPP) as an efficient tool to facilitate early planning and decision making during the children-centric formulation design for new chemical entities, or to repurpose/reformulate off-patent drugs. Essential key attributes of a paediatric formulation are suggested and described. Moreover, greater collaboration between formulation experts and clinical colleagues, including healthcare professionals, is advocated to lead to safe and effective, age-appropriate medicinal products. Acceptability testing should be a secondary endpoint in paediatric clinical trials to ensure post-marketing adherence is not compromised by a lack of acceptability. Not knowing the indications and the related age groups and potential dosing regimens early enough is still a major hurdle for efficient paediatric formulation development; however the proposed pQTPP could be a valuable collaborative tool for planning and decision making to expedite paediatric product development.

scholarly journals Advanced Computational Methods for Oncological Image Analysis

2021 ◽  
Vol 7 (11) ◽  
pp. 237
Author(s):  
Leonardo Rundo ◽  
Carmelo Militello ◽  
Vincenzo Conti ◽  
Fulvio Zaccagna ◽  
Changhee Han
Keyword(s):  
Image Analysis ◽  
Deep Learning ◽  
Computational Methods ◽  
State Of The Art ◽  
Original Research ◽  
Special Issue ◽  
Research Papers ◽  
Novel Algorithms

The Special Issue “Advanced Computational Methods for Oncological Image Analysis”, published for the Journal of Imaging, covered original research papers about state-of-the-art and novel algorithms and methodologies, as well as applications of computational methods for oncological image analysis, ranging from radiogenomics to deep learning [...]

scholarly journals Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride

2018 ◽  
Vol Volume 12 ◽  
pp. 349-364 ◽  
Author(s):  
Rouf Akram ◽  
Mahmood Ahmad ◽  
Asad Abrar ◽  
Rai Muhammad Sarfraz ◽  
Asif Mahmood
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Matrix Diffusion ◽  
Design And Development ◽  
Formulation Design ◽  
Diffusion Controlled

scholarly journals Foreword – special issue Mycotoxins in China

2020 ◽  
Vol 13 (2) ◽  
pp. 119-120
Author(s):  
Hao Zhang ◽  
Yisheng Chen ◽  
Qi Zhang
Keyword(s):  
Food Systems ◽  
Mycotoxin Research ◽  
State Of The Art ◽  
Research Articles ◽  
Original Research ◽  
Special Issue ◽  
Deep Insight ◽  
Toxigenic Fungi ◽  
The World ◽  
Food And Feed

Mycotoxin contamination in agro-food systems has been a serious concern over the last few decades around the world, and very much as well in China. The change of climate and farming methods are favourable for prevalence of toxigenic fungi and consequently cause the increase of mycotoxins in food and feed. Against this background, this special issue ‘Mycotoxins in China’, consisting of five review and 12 original research articles, is dedicated to the most recent advances in both fundamental and applied mycotoxin research. Most of the authors are senior experts with multidisciplinary background. They provide a comprehensive discussion on state-of-the-art studies on mycotoxins in China, covering microbiology, toxicology, chemistry and statistics. We hope that the papers collected here will provide deep insight and inspiration to the readers to further improve strategies, technologies and methods dealing with the analysis, degradation and prevention of mycotoxin, not only in China, but around the world.

scholarly journals Recent Advances in Mathematical Aspects of Engineering

Symmetry ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 811
Author(s):  
Rahmat Ellahi ◽  
Sadiq M. Sait ◽  
Huijin Xu
Keyword(s):  
State Of The Art ◽  
Experimental Studies ◽  
The State ◽  
Original Research ◽  
Theoretical Studies ◽  
Special Issue ◽  
Mathematical Methods ◽  
Recent Advances ◽  
Engineering Problems ◽  
Research Findings

This special issue took this opportunity to invite researchers to contribute their latest original research findings, review articles, and short communications on advances in the state of the art of mathematical methods, theoretical studies, or experimental studies that extend the bounds of existing methodologies to new contributions addressing current challenges and engineering problems on “Recent Advances in Mathematical Aspects of Engineering” to be published in Symmetry.

Patient focused design and development of an age-appropriate paediatric formulation

2018 ◽  
Vol 536 (2) ◽  
pp. 509-510
Author(s):  
Floriane Séquier ◽  
Eileen McBride ◽  
Jonathan Booth ◽  
Sarah Hayter ◽  
Andrew Megarry ◽  
...  
Keyword(s):  
Design And Development ◽  
Age Appropriate ◽  
Paediatric Formulation
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