Effects of different exercise protocols on ethanol-induced spatial memory impairment in adult male rats

Alcohol ◽  
2013 ◽  
Vol 47 (4) ◽  
pp. 309-316 ◽  
Author(s):  
T. Hashemi Nosrat Abadi ◽  
L. Vaghef ◽  
S. Babri ◽  
M. Mahmood-Alilo ◽  
M. Beirami
Keyword(s):  
Spatial Memory ◽  
Adult Male ◽  
Memory Impairment ◽  
Male Rats

Effect of vitamin E on cisplatin-induced memory impairment in male rats

2020 ◽  
pp. 1-6
Author(s):  
Masoud Hosseinzadeh ◽  
Amir Alizadeh ◽  
Parnian Heydari ◽  
Marzieh Kafami ◽  
Mahmoud Hosseini ◽  
...  
Keyword(s):  
Vitamin E ◽  
Spatial Memory ◽  
Memory Impairment ◽  
Saline Solution ◽  
Male Rats ◽  
Control Group ◽  
Sod Activity ◽  
The Central Nervous System ◽  
Pre Treatment ◽  
And Oxidative Stress

Abstract Objective: Neurotoxicity is an adverse effect caused by cisplatin due to inflammation and oxidative stress in the central nervous system. The present study aimed to assess the effects of vitamin E injection on the learning and memory of rats with cisplatin-induced cognitive impairment. Methods: Male rats were administered with cisplatin (2 mg/kg/7 day; intraperitoneally [i i.p.]) and/or vitamin E (200 mg/kg/7 day; i.p.) for 1 week, and the control group received saline solution. Spatial memory was evaluated using Morris water maze (MWM). In addition, the hippocampal concentrations of malondialdehyde (MDA), thiol, and superoxide dismutase (SOD) were measured using biochemical methods. Results: According to the findings, cisplatin significantly increased the escape latency, while decreasing the time spent and travelled pathway in the target quadrant on the final trial day compared to the control group. Furthermore, pre-treatment with vitamin E significantly reversed all the results in the spatial memory test. The biochemical data indicated that vitamin E could decrease MDA activity and increase thiol and SOD activity compared to the control group. Conclusion: According to the results, vitamin E could improve cisplatin-induced memory impairment possibly through affecting the hippocampal oxidative status.

scholarly journals Effects of testosterone dose on spatial memory among castrated adult male rats

2018 ◽  
Vol 89 ◽  
pp. 120-130 ◽  
Author(s):  
Benjamin A. Wagner ◽  
Valerie C. Braddick ◽  
Christopher G. Batson ◽  
Brendan H. Cullen ◽  
L. Erin Miller ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Adult Male ◽  
Male Rats

scholarly journals Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

2019 ◽  
Vol 8 ◽  
pp. 1182 ◽  
Author(s):  
Solmaz Khalifeh ◽  
Mehdi Khodamoradi ◽  
Vahid Hajali ◽  
Hamed Ghazvini ◽  
Lelia Eliasy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Memory Performance ◽  
Poor Performance ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Opiate Antagonist

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

scholarly journals The effect of nigella sativa extract on learning and spatial memory of adult male rats

2014 ◽  
Vol 12 (1) ◽  
pp. 27-36
Author(s):  
zahra tamadonfard ◽  
lili sepehrara ◽  
habibolah jovhary
Keyword(s):  
Spatial Memory ◽  
Adult Male ◽  
Nigella Sativa ◽  
Male Rats

scholarly journals Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

2014 ◽  
Vol 115 (1-2) ◽  
pp. 43-59 ◽  
Author(s):  
Romana Šlamberová ◽  
Eva Macúchová ◽  
Kateryna Nohejlová ◽  
Andrea Štofková ◽  
Jana Jurčovičová
Keyword(s):  
Spatial Memory ◽  
Adult Male ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Female Rats ◽  
Male Rats ◽  
Daily Injection ◽  
Drug Seeking ◽  
Male And Female ◽  
Male And Female Rats

The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA- or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure.

Effects of post-training administration of LY341495, as a mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet

2020 ◽  
Author(s):  
Heresh Moridi ◽  
Abdolrahman Sarihi ◽  
Elahe Habibitabar ◽  
Hossein Shateri ◽  
Iraj Salehi ◽  
...  
Keyword(s):  
Spatial Memory ◽  
High Fat Diet ◽  
Memory Impairment ◽  
Metabotropic Glutamate Receptors ◽  
Reference Memory ◽  
Memory Deficit ◽  
Male Rats ◽  
High Fat ◽  
Target Zone ◽  
Spatial Memory Deficit

Abstract Background High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD by using Morris Water Maze (MWM) task. Intraperitoneal injection (i.p) injection of LY341495 was done 30 minutes before retention test. Results Our results showed that HFD did not have any effect on memory acquisition. There were not significant differences in escape latency and swimming distance between experimental groups (P>0.05, Two-way ANOVA). Our finding showed that consumption of an HFD leads to spatial memory impairment. There were significant differences in time spent in target zone between experimental groups [F (3, 20) = 7.031, P=0.0021, one-way ANOVA]. Also, LY341495 improved HFD-induced reference memory impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals (P= 0.0449). Conclusions Our results suggested that prolonged consumption of high-fat diet has no effects on the acquisition of spatial learning, but can impair memory retention of the adult male rats and post-training administration of LY341495 can improve HFD-induced reference memory impairment.

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