Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men: The Guangzhou Biobank Cohort Study

The purpose of this study was to assess the prevalence of left ventricular hypertrophy in adolescents with persistently elevated blood pressures. Chest roentgenograms, electrocardiograms, and echocardiograms were performed on 50 adolescents with elevated blood pressure and 50 matched normotensive control subjects. No subject in either group demonstrated cardiomegaly on x-ray. Interpretation of the electrocardiograms indicated that similar numbers of both hypertensive (7/50) and control subjects (8/50) had ECG evidence of left ventricular hypertrophy. The echocardiograms showed that the mean left ventricular wall thickness (LVWT) in the hypertensive adolescents was 7.8 mm ± 0.1 (SE), compared with 6.5 ± 0.1 in the control subjects (P < .001). When the measurements were indexed to body surface area, the difference remained highly significant. Indexed left ventricular mass (LVM)/body surface area (BSA) was also significantly greater (P < .001) in the hypertensive (84.2 gm/sq m ± 2.1) than in the control subjects (72.0 ± 2.1). Using data from the normotensive control subjects, we defined the 95th percentile for both LVWT/BSA and LVM/BSA. Among hypertensive adolescents, 9/50 had LVWT/BSA and 8/50 had LVM/BSA above this level. For control subjects, only 1/50 had elevated LVWT/BSA values and 2/50 elevated LVM/BSA values. This study demonstrates that hypertensive adolescents have an increased prevalence of left ventricular hypertrophy and that echocardiography is the most useful noninvasive method to detect these changes.

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Left Ventricular Hypertrophy in Young Africans With First Ever Stroke in Tanzania: A Prospective Cohort Study

10.21203/rs.3.rs-324415/v1 ◽

2021 ◽

Author(s):

Sarah Shali Matuja ◽

Patricia Munseri ◽

Candida Moshiro ◽

Khuzeima Khanbhai ◽

Karim Mahawish

Keyword(s):

Blood Pressure ◽

Cohort Study ◽

Left Ventricular Hypertrophy ◽

Brain Imaging ◽

Ventricular Hypertrophy ◽

Young Patients ◽

Functional Independence ◽

Left Ventricular ◽

Vascular Events ◽

The Mean

Abstract Background: Left ventricular hypertrophy is a pathophysiological response to chronic hypertension and is an independent risk factor for vascular events. We sought to determine the magnitude, correlates and prognosis of left ventricular hypertrophy in young patients presenting with their first stroke at a tertiary hospital. We also sought to determine the accuracy of electrocardiography using Sokolow-Lyon and Cornell criteria in detecting left ventricular hypertrophy compared to echocardiography.Methods: This cohort study prospectively recruited consecutive stroke patients aged 18-45 years who had undergone brain imaging, electrocardiogram and transthoracic echocardiography. Baseline data were recorded and correlates of left ventricular hypertrophy were identified using the modified Poisson regression. Follow-up for functional outcomes was performed to 30-days using the modified Rankin Scale.Results: We enrolled 101 participants with first ever stroke. The mean age of patients was 39.7years and the mean National Institutes of Health Stroke Score was 18, reflecting severe disability. Brain imaging revealed ischemic strokes in 60 (59.4%) of patients and of those with intracerebral hemorrhage, 33 (86.8%) were localized to the basal ganglia, in keeping with a hypertensive etiology. Left ventricular hypertrophy was present in 76 (75.3%; 95% CI 65.7% – 83.3%), and 30 (39.5%) and 28 (36.8%) had moderate to severe degree respectively. Young adults with left ventricular hypertrophy were more likely to have a higher systolic and diastolic blood pressure on arrival 156.3±19 and 96.4±10.6 respectively. On multivariable analysis, lack of antihypertensive medication was associated with left ventricular hypertrophy {adjusted risk ratio 1.42 (95% CI: 1.04–1.94). The sensitivity and specificity for Sokolow-Lyon in detecting left ventricular hypertrophy was 27% and 78%, and for Cornell was 32% and 52% respectively. At 30-days, functional independence was achieved in 12 (12.4%) and almost half had died.Conclusions: There is a high burden of left ventricular hypertrophy in young patients with first stroke. Untreated hypertension is the likely etiology associated with a high 30-day mortality. Our findings did not support the use of the electrical voltage criteria for detecting left ventricular hypertrophy. We recommend low cost interventions such as blood pressure screening and control to reduce this burden in the young.

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The association of obstructive sleep apnea and left ventricular hypertrophy in obese and overweight children with history of elevated blood pressure

Journal of Clinical Hypertension ◽

10.1111/jch.13605 ◽

2019 ◽

Vol 21 (7) ◽

pp. 984-990 ◽

Cited By ~ 4

Author(s):

Colleen E. Hanlon ◽

Edem Binka ◽

Jeffrey S. Garofano ◽

Laura M. Sterni ◽

Tammy M. Brady

Keyword(s):

Blood Pressure ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Left Ventricular Hypertrophy ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Elevated Blood ◽

Overweight Children ◽

Obstructive Sleep ◽

History Of

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Similarities and Differences in Epidemiology and Risk Factors of Cerebral and Myocardial Ischemic Disease

Serbian Journal of Experimental and Clinical Research ◽

10.1515/sjecr-2017-0045 ◽

2017 ◽

Vol 18 (s1) ◽

pp. 75-80

Author(s):

Angelina Stevanovic ◽

Danijela Tasic ◽

Nebojsa Tasic ◽

Dalibor Dragisic ◽

Miroslav Mitrovic ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Myocardial Infarction ◽

Blood Pressure ◽

Ischemic Stroke ◽

Alcohol Consumption ◽

Left Ventricular Hypertrophy ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

History Of

Abstract Ischemic heart disease and cerebral ischemia represent the leading causes of mortality worldwide. Both entities share risk factors, pathophisiology and etiologic aspects by means of a main common mechanism, atherosclerosis. The autors aimed to investigate differences and similarities in epidemiology and risk factors that could be found between both entities. In a retrospective sudy 403 patients were included and divided into two groups: group of 289 patients with history of myocardial infarction (AMI), and group of 114 patients with history of ischemic stroke (IS). All patients were evaluated for nonmodifiable risk faktors, which included age and sex, and modifiable, such as hypertension, dyslipidemia, diabetes, obesity, physical activity and smoking. Diff erences in some epidemiological aspects were also considered: occupation, marital status, alcohol consumption, exposure to stress. Patients with history of IS were significantly older then AMI patients (64.0 ± 9.9 vs 64.0 ± 9.9, p=0,028), with higher diastolic blood pressure (87,1 ± 10,2 vs 83,6 ± 10,4, p=0,003) and higher Sokolow-Lyon index in ECG, an also index of left ventricular hypertrophy (19,2 ± 9,1 vs 14,7 ± 6,5). Th ere were no significant differences between groups in the estimated body mass index and waist circumference. Differences between groups in stress exposure, occupation, alcohol consumption or physical activity were no significant. Patients in AMI group were more frequently male (199 (69%) vs 59 (52%), p=0,001), married (252 (87%) vs 88 (77%), p=0,037), smokers (162 (56%) vs 50 (44%), p=0,018) and with higher incidence od dyslipidemia (217 (75%) vs 73 (64%), p=0,019) compared with IS group. Incidence of arterial hypertension and diabetes was similar in both groups. Both entities share similar pathophysiological mechanisms and, consequently, main traditional risk factors. However, incidence of myocardial infarction increases with male sex, dyslipidemia, smoking and marital status, while incidense of ischemic stroke increases with age, higher diastolic blood pressure and also with ECG signs of left ventricular hypertrophy.

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