Unexpected cross-reactivity in a cat-allergy patient. An allergic reaction at the circus

2014 ◽  
Vol 42 (6) ◽  
pp. 624-625 ◽  
Author(s):  
W. Feleszko ◽  
B.M. Zalewski ◽  
M. Kulus
Keyword(s):  
Allergic Reaction ◽  
Cross Reactivity ◽  
Cat Allergy

scholarly journals Allergy to cephalosporin antibiotics in children

2003 ◽  
Vol 131 (3-4) ◽  
pp. 127-130 ◽  
Author(s):  
Marina Atanaskovic-Markovic ◽  
Branimir Nestorovic
Keyword(s):  
Allergic Reaction ◽  
Cross Reactivity ◽  
Skin Tests ◽  
Allergic Reactions ◽  
First Line ◽  
Positive Skin ◽  
Cephalosporin Antibiotics ◽  
The Cross ◽  
Single Blind ◽  
Common Infections

A particular problem is the safety of administering cephalosporins to penicillin-allergic children, because cephalosporin allergenic determinants have not been properly identified. Cephalosporin antibiotics are widely used to treat common infections and are often the first-line prophylaxis before many types of surgery. So the arm of this study is to determine the frequency of allergic reactions of anaphylactic type to cephalosporins and their cross-reactivity with penicillins. At University Children?s Hospital in Belgrade a group of 1,170 children with suspected anaphylactic allergic reaction to penicillins and/or cephalosporins were tested for the last eight years. Skin tests were performed with standard concentration of penicillins and cephalosporins. In children where skin tests were negative single-blind placebo-controlled challenges were performed. In case of positive skin tests further examinations were interrupted and the children were considered allergic to that drug. The frequency of anaphylactic allergic reactions to cephalosporins is 0.2 % to 17 %, and depends on cephalosporins generation. The cross-reactivity between cephalosporins and penicillins is 0.1 % to 14.5 %, and among cephalosporins is 0 % to 11.7 %.

Allergic reaction to prasugrel and cross-reactivity with clopidogrel

2012 ◽  
Vol 157 (3) ◽  
pp. e48-e49 ◽  
Author(s):  
Bruria Hirsh Raccah ◽  
Meir Shalit ◽  
Haim D. Danenberg
Keyword(s):  
Allergic Reaction ◽  
Cross Reactivity

scholarly journals AllerScreener – A Server for Allergenicity and Cross-Reactivity Prediction

2020 ◽  
Vol 20 (6) ◽  
pp. 175-184
Author(s):  
Ivan Dimitrov ◽  
Mariana Atanasova
Keyword(s):  
Allergic Reaction ◽  
Human Leukocyte ◽  
Class Ii ◽  
Cross Reactivity ◽  
Hla Class Ii ◽  
Human Leukocyte Antigens ◽  
Novel Proteins ◽  
Leukocyte Antigens ◽  
Allergenic Proteins ◽  
Antigen Presenting

AbstractAllergenicity of proteins is a subtle property encoded in their structures. The prediction of allergenicity of novel proteins saves time and resources for subsequent experimental work. In the host antigen-presenting cells, the allergens are processed as antigens by the means of Human Leukocyte Antigens (HLA) class II proteins. Sometimes, people allergic to a given protein show allergic reaction to a different protein, even when the two proteins have different routes of exposure. This phenomenon is termed cross-reactivity. Here, we describe a server for allergenicity and cross-reactivity prediction based on the abilities of allergenic proteins to generate binders to HLA class II proteins. The generated peptides are compared to HLA binders originating from known allergens. As a result, the server returns a list of common binders, origin proteins, and species. Different species generate common HLA binders and this determines their cross-reactivity. The server is named AllerScreener and is freely accessible at: http://www.ddg-pharmfac.net/AllerScreener.

Allergic Reaction to Polyether Ether Ketone Following Cross-Reactivity to Epoxy Resin

2016 ◽  
Vol 21 (1) ◽  
pp. 78-79 ◽  
Author(s):  
Lukas Kofler ◽  
Markus Wambacher ◽  
Katrin Schweinzer ◽  
Maritta Scherl ◽  
Heinz Kofler
Keyword(s):  
Allergic Reaction ◽  
Epoxy Resin ◽  
Cross Reactivity ◽  
Occupational Contact Dermatitis ◽  
Type Iv ◽  
Polyether Ether Ketone ◽  
Patient Reported ◽  
Ether Ketone ◽  
Type Iv Allergy ◽  
Occupational Contact

Polyether ether ketone (PEEK) is a thermoplastic polymer frequently used in engineering but also in medical devices. Only 1 case of allergic reaction to PEEK used as an implanted medical device has been reported so far; however, the route of sensitization remained unclear. Here we report on a 62-year-old male patient with a preknown, severe type IV allergy to epoxy resin. He reported strong pain in his shoulder after implantation of a PEEK-containing device after a rotator cuff injury. For testing, the device was implanted in a small pouch subcutaneously on the abdomen. The patient reported massive pain starting 8 hours after the implantation, strictly limited to the procedural area and showing perifocal erythema. A possible explanation of the sensitization mode is the source material for PEEK and epoxy resin, as both are mainly based on bisphenols. An allergic reaction to PEEK with preknown epoxy resin sensitization has not been reported so far. As epoxy resins are a frequent cause of occupational contact dermatitis and PEEK is widely used for medical and nonmedical devices, we believe that this is of great clinical relevance.

Successful treatment of trichomoniasis with tinidazole following desensitization in a patient allergic to metronidazole

2020 ◽  
pp. 095646242096391 ◽  
Author(s):  
Mark Biagi ◽  
Wendy Slipke ◽  
Alexa Smalley ◽  
Geoffrey Tsaras
Keyword(s):  
Adverse Effects ◽  
Allergic Reaction ◽  
Successful Treatment ◽  
Cross Reactivity ◽  
Alternative Therapies ◽  
Burning Sensation ◽  
Effective Alternative ◽  
Whole Body ◽  
History Of

Metronidazole desensitization is recommended in patients with trichomoniasis and history of an allergic reaction to metronidazole due to presumed cross reactivity with tinidazole and lack of reliably safe and effective alternative therapies. We report our experiences in a patient with persistent trichomoniasis who failed to complete metronidazole desensitization due to a burning sensation over her whole body and pruritus but was later successfully desensitized to tinidazole without experiencing any adverse effects.

scholarly journals Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids

2012 ◽  
Vol 140 (3-4) ◽  
pp. 233-235 ◽  
Author(s):  
Marina Atanaskovic-Markovic ◽  
Marija Gavrovic-Jankulovic ◽  
Srdja Jankovic ◽  
Gordan Blagojevic ◽  
Tanja Cirkovic-Velickovic ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Anaphylactic Reaction ◽  
Skin Testing ◽  
Cross Reactivity ◽  
Clinical Findings ◽  
Skin Tests ◽  
Type I ◽  
Positive Skin ◽  
Uncommon Case ◽  
Type I Hypersensitivity

Introduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT) was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule.

scholarly journals Pollen-food allergy syndrome in children

2020 ◽  
Vol 63 (12) ◽  
pp. 463-468 ◽  
Author(s):  
You Hoon Jeon
Keyword(s):  
Food Allergy ◽  
Allergic Reaction ◽  
Pediatric Patients ◽  
Immunoglobulin E ◽  
Pollen Allergy ◽  
Heat Stability ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Food Ingestion ◽  
Systemic Reactions

Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods—such as fruits, vegetables, or nuts—in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. PFAS is often called oral allergy syndrome because of mild symptoms such as itching, urticaria, and edema mainly in the lips, mouth, and pharynx that appear after food ingestion. However, reports of systemic reactions such as anaphylaxis have been increasing recently. This diversity in the degree of symptoms is related to the types of trigger foods and the characteristics of allergens, such as heat stability. When pediatric patients with pollen allergy are treated, attention should be paid to PFAS and an active effort should be made to diagnose it.

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