Do NSAIDs Affect Longitudinal Changes in Knee Cartilage Volume and Knee Cartilage Defects in Older Adults?

2009 ◽  
Vol 122 (9) ◽  
pp. 836-842 ◽  
Author(s):  
Changhai Ding ◽  
Flavia Cicuttini ◽  
Graeme Jones
Keyword(s):  
Older Adults ◽  
Cartilage Volume ◽  
Cartilage Defects ◽  
Knee Cartilage ◽  
Longitudinal Changes

Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study

2014 ◽  
Vol 75 (3) ◽  
pp. 519-525 ◽  
Author(s):  
Xia Wang ◽  
Leigh Blizzard ◽  
Andrew Halliday ◽  
Weiyu Han ◽  
Xingzhong Jin ◽  
...  
Keyword(s):  
Older Adults ◽  
Knee Joint ◽  
Structural Changes ◽  
Cartilage Volume ◽  
Joint Effusion ◽  
Cartilage Defects ◽  
Knee Cartilage ◽  
Cross Sectional ◽  
Causal Pathways ◽  
Suprapatellar Pouch

ObjectiveTo describe the cross-sectional and longitudinal associations between knee regional effusion-synovitis and structural changes in older adults.MethodsA total of 977 subjects were randomly selected from the local community (mean 62 years, 50% female) at baseline and 404 were followed up 2.6 years later. T2-weighted MRI was used to assess knee effusion-synovitis in four subregions: suprapatellar pouch, central portion, posterior femoral recess and subpopliteal recess. Knee cartilage defects, cartilage volume and bone marrow lesions (BMLs) were measured using MRI at baseline and follow-up.ResultsCross-sectionally, effusion-synovitis in most subregions was significantly associated with a higher risk of cartilage defects, BMLs and reduced cartilage volume. Longitudinally, suprapatellar pouch effusion-synovitis at baseline predicted an increase in cartilage defects (p<0.01), loss of cartilage volume (p=0.04) and an increase in BMLs (p=0.02) in multivariable analyses. The significant associations of effusion-synovitis with cartilage volume and BMLs disappeared after adjustment for cartilage defects. Effusion-synovitis in whole knee joint (p<0.01) and subpopliteal recess (p<0.05) was consistently associated with longitudinal changes in cartilage defects but not in cartilage volume and BMLs.ConclusionsThere are independent associations between knee joint effusion-synovitis and knee cartilage defects in both cross-sectional and longitudinal analyses, suggesting a potential causal relationship. The associations of effusion-synovitis with BMLs and cartilage volume were largely dependent on cartilage defects, suggesting potential causal pathways.

scholarly journals Association between knee cartilage volume and bone mineral density in older adults without osteoarthritis

Rheumatology ◽  
2004 ◽  
Vol 43 (6) ◽  
pp. 765-769 ◽  
Author(s):  
F. Cicuttini ◽  
A. Wluka ◽  
S. Davis ◽  
B. J. G. Strauss ◽  
S. Yeung ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Bone Mineral ◽  
Cartilage Volume ◽  
Knee Cartilage ◽  
Mineral Density

scholarly journals Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

2020 ◽  
Vol 50 (2) ◽  
pp. 192-197
Author(s):  
Tao Meng ◽  
Benny Antony ◽  
Alison Venn ◽  
Brooklyn Fraser ◽  
Flavia Cicuttini ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Adults ◽  
Glucose Homeostasis ◽  
Cartilage Volume ◽  
Cartilage Defects ◽  
Knee Cartilage ◽  
And Cartilage
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