Community-Acquired Pneumonia in Patients With Diabetes Mellitus: Predictors of Complications and Length of Hospital Stay

2016 ◽  
Vol 352 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Mazen S. Bader ◽  
Yanqing Yi ◽  
Kassem Abouchehade ◽  
Babar Haroon ◽  
Lisa D. Bishop ◽  
...  
The Lancet ◽  
2011 ◽  
Vol 377 (9782) ◽  
pp. 2023-2030 ◽  
Author(s):  
Sabine CA Meijvis ◽  
Hans Hardeman ◽  
Hilde HF Remmelts ◽  
Rik Heijligenberg ◽  
Ger T Rijkers ◽  
...  

2004 ◽  
Vol 34 (3) ◽  
pp. 91-97 ◽  
Author(s):  
R. Laing ◽  
C. Coles ◽  
S. Chambers ◽  
C. Frampton ◽  
L. Jennings ◽  
...  

2018 ◽  
Vol 51 (4) ◽  
pp. 1701389 ◽  
Author(s):  
Fahim Ebrahimi ◽  
Stavros Giaglis ◽  
Sinuhe Hahn ◽  
Claudine A. Blum ◽  
Christine Baumgartner ◽  
...  

Neutrophil extracellular traps (NETs) are a hallmark of the immune response in inflammatory diseases. However, the role of NETs in community-acquired pneumonia (CAP) is unknown. This study aims to characterise the impact of NETs on clinical outcomes in pneumonia.This is a secondary analysis of a randomised controlled, multicentre trial. Patients with CAP were randomly assigned to either 50 mg prednisone or placebo for 7 days. The primary end-point was time to clinical stability; main secondary end-points were length of hospital stay and mortality.In total, 310 patients were included in the analysis. Levels of cell-free nucleosomes as surrogate markers of NETosis were significantly increased at admission and declined over 7 days. NETs were significantly associated with reduced hazards of clinical stability and hospital discharge in multivariate adjusted analyses. Moreover, NETs were associated with a 3.8-fold increased adjusted odds ratio of 30-day mortality. Prednisone treatment modified circulatory NET levels and was associated with beneficial outcome.CAP is accompanied by pronounced NET formation. Patients with elevated serum NET markers were at higher risk for clinical instability, prolonged length of hospital stay and 30-day all-cause mortality. NETs represent a novel marker for outcome and a possible target for adjunct treatments of pneumonia.


2018 ◽  
Vol 42 (5) ◽  
pp. 579 ◽  
Author(s):  
C. M. Horwood ◽  
P. Hakendorf ◽  
C. H. Thompson

Objective The choice of whether to admit under a specialist or a generalist unit is often made with neither clear rationale nor understanding of its consequences. The present study compared the characteristics and outcomes of patients admitted with community-acquired pneumonia to either a general medicine or respiratory unit. Methods This study was a retrospective cross-sectional study using data from public hospitals in Adelaide, South Australia. Over 5 years there were 9775 overnight, unplanned appropriate adult admissions. Patient length of hospital stay, in-patient mortality rate and 30-day unplanned readmission rate were calculated, with and without adjustment for patient age and comorbidity burden. Results Over 80% of these patients were cared for by a general medicine unit rather than a specialist unit. Patients admitted to a general medicine unit were, on average, 4 years older than those admitted to a respiratory unit. Comorbidity burdens were similar between units at the same hospital. Length of in-patient stay was >1 day shorter for those admitted to a general medicine unit, without significant compromise in mortality or readmission rates. Between each hospital, general medicine units showed a range of mortality rates and length of hospital stay, for which there was no obvious explanation. Conclusions Compared with speciality care, general medicine units can safely and efficiently care for patients presenting to hospital with community-acquired pneumonia. What is known about the topic? Within the narrow range of any specific disease, generalist medical services are often cited as inferior in performance compared with a speciality service. This has implications for hospital resourcing, including both staffing and ward allocation. What does this paper add? This paper demonstrates that most patients admitted with a principal diagnosis of community-acquired pneumonia were admitted to a generalist unit and did not apparently fare worse than patients admitted to a specialist service; patients admitted to a generalist unit spent less time in hospital and there was no difference in mortality or readmission rate compared with patients admitted to a specialist service. What are the implications for practitioners? The provision of generalist services at urban hospitals in Australia provides a safe alternative admission option for patients presenting with pneumonia, and possibly for other common acute medical conditions.


2000 ◽  
Vol 109 (5) ◽  
pp. 378-385 ◽  
Author(s):  
Michael J Fine ◽  
Hugh M Pratt ◽  
D.Scott Obrosky ◽  
Judith R Lave ◽  
Laura J McIntosh ◽  
...  

Author(s):  
A. S. Imankulova ◽  
O. T. Kochorov ◽  
U. T. Naraliev

Fournier’s gangrene (FG) is a septic process accompanied by tissue necrosis of the scrotum, penis and perineum, as well as systemic inflammatory syndrome and endotoxicosis. FG is associated with long hospital stay and high mortality. In recent decades, there has been an increase in the incidence of this pathology, as evidenced by the indicators of the “database of the treated case” in Kyrgyzstan. This fact is associated with the growth of immunocompromised patients and, first of all, patients with diabetes mellitus. The result of treatment depends on the correct tactics, time and volume of emergency surgery. This article presents a 5-year experience of treating patients with FG against the background of diabetes mellitus in the department of purulent surgery of the National Hospital in Bishkek.


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