Optical Coherence Tomography: A Non-Invasive Method to Assess Wound Healing

2005 ◽  
Vol 46 (3) ◽  
pp. 68
Author(s):  
A.J. Singer ◽  
Z. Wang ◽  
S.A. McClain ◽  
Y. Pan
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

scholarly journals Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 217
Author(s):  
Maria Jesus Rodrigo ◽  
Amaya Pérez del Palomar ◽  
Alberto Montolío ◽  
Silvia Mendez-Martinez ◽  
Manuel Subias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Therapeutic Option ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Aggregate Size ◽  
Daily Practice ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

2013 ◽  
Vol 20 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Monika Kuck ◽  
Helene Strese ◽  
Seyed Arash Alawi ◽  
Martina C. Meinke ◽  
Joachim W. Fluhr ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Diagnostic Tool ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Non Invasive

scholarly journals Optical coherence tomography as a non-invasive method of enamel thickness diagnosis after orthodontic treatment by 3 different types of brackets

2019 ◽  
Vol 28 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Monika Machoy ◽  
Robert Koprowski ◽  
Liliana Szyszka-Sommerfeld ◽  
Krzysztof Safranow ◽  
Tomasz Gedrange ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Orthodontic Treatment ◽  
Optical Coherence ◽  
Enamel Thickness ◽  
Non Invasive ◽  
Different Types ◽  
Invasive Method

scholarly journals Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

2020 ◽  
Author(s):  
Maria Jesus Rodrigo ◽  
Amaya Pérez del Palomar ◽  
Alberto Montolío ◽  
Silvia Mendez-Martinez ◽  
Manuel Subias ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Relative Intensity ◽  
Therapeutic Option ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Aggregate Size ◽  
Daily Practice ◽  
Optical Coherence ◽  
Non Invasive ◽  
Invasive Method

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine-Laponite (BRI/LAP) can be monitored non-invasively using vitreous imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterization was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

scholarly journals Munch and optical coherence tomography: unravelling historical and artist applied varnish layers in painting collections

2021 ◽  
Vol 136 (9) ◽  
Author(s):  
Thierry Ford ◽  
Magdalena Iwanicka ◽  
Elena Platania ◽  
Piotr Targowski ◽  
Ella Hendriks
Keyword(s):  
Optical Coherence Tomography ◽  
Large Scale ◽  
Imaging Techniques ◽  
Optical Coherence ◽  
Interferometric Technique ◽  
Conservation Treatment ◽  
Non Invasive ◽  
Effective Care ◽  
Art Works ◽  
Invasive Method

AbstractEffective care of large-scale museum collections requires planning that includes the conservation treatment of specific groups of art works, such as appropriate cleaning strategies. Optical coherence tomography (OCT) has been successfully applied as a non-invasive method for the stratigraphic visualisation of the uppermost transparent and semi-transparent layers in paintings, such as varnishes. Several OCT case study examples have further demonstrated the capabilities of the non-contact interferometric technique to measure the thickness of the various varnish layers, to help monitor cleaning and associated optical changes, and to detect past restorations. OCT was applied for the detection of varnishes to 13 paintings by Edvard Munch (1863–1944) owned by the Norwegian National Museum of Art. The paintings have a controversial and complex varnish history and are displayed as a group according to their acquisition legacy. A prototype high-resolution portable SdOCT instrument was used in combination with complementary imaging techniques. Questions concerning thickness, stratigraphy and the identification/location of the artist’s original varnish layers and/or pigmented glazes were addressed. Findings confirmed the complexity of the historical layers present and provided new evidence for Munch’s use of transparent and semi-transparent layers as part of an occasional, localised varnishing and/or glazing technique.

scholarly journals Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

2021 ◽  
Vol 14 (2) ◽  
pp. 90-95
Author(s):  
M. S. Krivosheeva ◽  
E. E. Ioyleva
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Microcirculatory Bed ◽  
Non Invasive ◽  
Invasive Method

The review discusses the development of optical coherence tomography with the function of angiography, focusing on its advantages, features, and prospects for the diagnosis of fundus pathologies.

scholarly journals Optical Coherence Tomography Reveals Self-Organizing Di-Fork Architecture of Mice Cutaneous Scars

2017 ◽  
Author(s):  
Biswajoy Ghosh ◽  
Mousumi Mandal ◽  
Pabitra Mitra ◽  
Jyotirmoy Chatterjee
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Steady State ◽  
Wound Repair ◽  
Stable State ◽  
Tissue Mechanics ◽  
Tissue Loss ◽  
Optical Coherence ◽  
Non Invasive ◽  
Self Organizing

AbstractScientific studies report crucial impacts of biomechanical effectors to modulate wound healing either by scarring or regeneration. Further, the biological decision to predominantly favor the former is still cryptic. Real-time visualization of biomechanical manifestations in situ in scarring is hence necessary. Endorsed by nanostructural testing, synthetic phantom analysis, and computational simulations, we found strong mechanobiological correlates for Swept Source Optical Coherence Tomography (SS-OCT) speckles in mice cutaneous repair (full-thickness) up to 10 months. The theoretical basis of the optomechanics to provide insights into scar form-factor and evolution is proposed. Optomechanical changes have been considered as the resultant of intrinsic (e.g. fiber elastic modulus) and gross tissue mechanics (extracellular matrix (ECM)) in maturing scars. Non-invasive optomechanics supported with microscopic findings reveal scar’s cross-sectional self-organizing di-fork architecture. Dual-compartment heterogeneity of di-fork exhibits stress-evading features with a dichotomy in inhabitant cellular stress-fiber distributions. This differential interactivity of scar with adjoining tissues reflects its architectural intelligence to compensate tissue loss (hypodermis/muscle) by assembling into a di-fork. Gradual establishment of baseline shifted lasting mechanobiological steady-state, later in scarring, expose scar as an alternate stable state within the skin.Significance StatementWound repair in mammals, predominantly culminates into function compromising scar that is occasionally fatal in vital organs. How the biological system often adopts scarring over a restorative regeneration is yet a conundrum. Wound and ambient mechanics play a pivotal role in deciding the healing fate. SS-OCT is hence demonstrated here as a non-invasive window to such mechanical manifestations during skin wound healing. This exposed gradual emergence of temporally maintained and stress-resilient di-fork architecture of the scar with differential neighborhood interfaces. Accommodation of such an alternate self-organizing steady-state of scar sheds light on its sustenance and paradoxical selection.

scholarly journals Enhancing microvasculature maps for Optical Coherence Tomography Angiography (OCT-A)

2018 ◽  
Vol 10 (3) ◽  
pp. 61
Author(s):  
Mounika Rapolu ◽  
Paulina Niedźwiedziuk ◽  
Dawid Borycki ◽  
Paweł Wnuk ◽  
Maciej Wojtkowski
Keyword(s):  
Optical Coherence Tomography ◽  
Multifractal Analysis ◽  
Quantitative Information ◽  
Live Imaging ◽  
Optical Coherence ◽  
Optical Coherence Microscopy ◽  
Processing Methods ◽  
Non Invasive ◽  
Mammalian Embryos ◽  
Invasive Method

OCT-A is becoming more popular in recent years and there is a high demand to improve the quality of angiograms as well as to extract quantitative information. We applied various processing methods for microvasculature enhancement like Hessian-Frangi to a data set obtained with Bessel and Gaussian OCT systems. We used angiogenesis, fractal and multifractal analysis to extract more quantitative information. We applied the processing methods for healthy, stroke, tumor progression and the results of enhanced processing and quantitative analysis for those are presented in this letter. Full Text: PDF ReferencesJ. G. Fujimoto, C. Pitris, S. A. Boppart, and M. E. Brezinski, "Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos", Neoplasia (New York, NY), 2000, 2(1-2):9-25 CrossRef O. Liba, E. D. SoRelle, D. Sen, and A. de la Zerda, "Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging", Sci Rep. 2016, 6(1):23337. CrossRef O Liba, M. D. Lew, E. D. SoRelle, et al., "Speckle-modulating optical coherence tomography in living mice and humans", Nat Commun. 2017, 8:15845. CrossRef K. Karnowski, A. Ajduk, B. Wieloch, et al., "Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos", Sci Rep. 2017, 7(1):4165. CrossRef V. J. Srinivasan, S. Sakadžić, I. Gorczynska, et al., "Quantitative cerebral blood flow with Optical Coherence Tomography", Opt Express. 2010, 18(3):2477. CrossRef S. Tamborski, H. C. Lyu, H. Dolezyczek, et al. Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain. Biomed Opt Express. 2016, 7(11):4400-4414. CrossRef A. F. Frangi, W. J. Niessen, K. L. Vincken, and M. A. Viergever, "Multiscale vessel enhancement filtering", Lect Notes Comput Sc. 1998;1496:130–137 CrossRef A. A. Ucuzian, A. A. Gassman, A. T. East, and H. P. Greisler , Journal of burn care & research: official publication of the American Burn Association 2010 , 31(1):158. CrossRef R. Lopes, and Betrouni, N. (2009). "Fractal and multifractal analysis: A review", Med. Image Anal. 13, 634–649. CrossRef J. W. Baish and R. K. Jain., "Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.", Cancer Res. 2000, Jul 15, 60(14):3683-8. DirectLink

Implant bone interface investigated with a non-invasive method: optical coherence tomography

2008 ◽  
Author(s):  
Cosmin Sinescu ◽  
Michael Hughes ◽  
Adrian Bradu ◽  
Meda Negrutiu ◽  
Carmen Todea ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bone Interface ◽  
Non Invasive ◽  
Invasive Method
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