1315P Impact of high fasting plasma glucose in the clinical outcome of patients with advanced NSCLC with PD-L1 ≥ 50% treated with frontline pembrolizumab

BackgroundThe burden of breast cancer has been increasing globally. The epidemiology burden and trends need to be updated. This study aimed to update the burden and trends of breast cancer incidences, deaths, and disability-adjusted life-years (DALYs) from 1990 to 2019, using the Global Burden of Disease 2019 study.MethodsThe data of incidences, deaths, DALYs, and age-standardized rates were extracted. Estimated annual percentage changes were used to quantify the trends of age-standardized rates. Besides, the population attributable fractions of the risk factors of breast cancer were also estimated.ResultsGlobally, the incidences of breast cancer increased to 2,002,354 in 2019. High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. In 2019, the global deaths and DALYs of breast cancer increased to 700,660 and 20,625,313, respectively. From 1990 to 2019, the age-standardized mortality rates and age-standardized DALY rates declined globally, especially in high and high-middle SDI quintiles. Besides, the trends varied from different regions and countries. The proportion of the patients in the 70+ years age group increased globally. Deaths of breast cancer attributable to high fasting plasma glucose and high body mass index increased globally, and high fasting plasma glucose was the greatest contributor to the global breast cancer deaths.ConclusionThe burden of breast cancer in higher SDI quintiles had gone down while the burden was still on the rise in lower SDI quintiles. It is necessary to appeal to the public to decrease the exposure of the risk factors.

Download Full-text

Global burden of noncommunicable diseases attributable to high fasting plasma glucose

Journal of Diabetes ◽

10.1111/1753-0407.13072 ◽

2020 ◽

Vol 12 (11) ◽

pp. 807-818

Author(s):

Lingxia Ye ◽

Jingya Xu ◽

Tianyue Zhang ◽

Xiling Lin ◽

Xiaowen Pan ◽

...

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Noncommunicable Diseases ◽

Global Burden ◽

Fasting Plasma ◽

High Fasting Plasma Glucose

Download Full-text

Risk factors for Type 2 Diabetes Mellitus in college students: association with sociodemographic variables

Revista Latino-Americana de Enfermagem ◽

10.1590/0104-1169.3053.2441 ◽

2014 ◽

Vol 22 (3) ◽

pp. 484-490 ◽

Cited By ~ 20

Author(s):

Adman Câmara Soares Lima ◽

Márcio Flávio Moura Araújo ◽

Roberto Wagner Júnior Freire de Freitas ◽

Maria Lúcia Zanetti ◽

Paulo César de Almeida ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

College Students ◽

Type 2 Diabetes ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Central Obesity ◽

Fasting Plasma ◽

High Fasting Plasma Glucose

OBJECTIVE: identify the modifiable risk factors for type 2 diabetes mellitus in college students and associate these factors with their sociodemographic variables.METHOD: cross-sectional study, involving 702 college students from Fortaleza-CE, Brazil. Sociodemographic, anthropometric, physical exercise data and blood pressure and fasting plasma glucose levels were collected.RESULTS: the most prevalent risk factor was sedentariness, followed by overweight, central obesity, high fasting plasma glucose and arterial hypertension. A statistically significant association was found between overweight and sex (p=0.000), age (p=0.004) and marital status (p=0.012), as well as between central obesity and age (p=0.018) and marital status (p=0.007) and between high fasting plasma glucose and sex (p=0.033).CONCLUSION: distinct risk factors were present in the study population, particularly sedentariness and overweight.

Download Full-text

The burden of diabetes and hyperglycemia in Brazil and its states: findings from the Global Burden of Disease Study 2015

Revista Brasileira de Epidemiologia ◽

10.1590/1980-5497201700050008 ◽

2017 ◽

Vol 20 (suppl 1) ◽

pp. 90-101 ◽

Cited By ~ 9

Author(s):

Bruce Bartholow Duncan ◽

Elisabeth Barboza França ◽

Valéria Maria de Azeredo Passos ◽

Ewerton Cousin ◽

Lenice Harumi Ishitani ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Burden Of Disease ◽

Global Burden Of Disease ◽

Global Burden ◽

Fasting Plasma ◽

Life Years ◽

High Fasting Plasma Glucose

ABSTRACT: Introduction and objective: The global burden of disease (GBD) 2015 project, extends GBD analyses to include Brazilian federative units separately. We take advantage of GBD methodological advances to describe the current burden of diabetes and hyperglycemia in Brazil. Methods: Using standard GBD 2015 methods, we analyzed the burden of diabetes, chronic kidney disease due to diabetes and high fasting plasma glucose in Brazil and its states. Results: The age-standardized rate of disability-adjusted life years (DALYs) which was lost to high fasting plasma glucose, a category which encompasses burdens of diabetes and of lesser hyperglycemia, were 2448.85 (95% UI 2165.96-2778.69) /100000 for males, and 1863.90 (95% UI 1648.18-2123.47) /100000 for females in 2015. This rate was more than twice as great in states with highest burden, these being overwhelmingly in the northeast and north, compared with those with lowest rates. The rate of crude DALYs for high fasting plasma glucose, increased by 35% since 1990, while DALYs due to all non-communicable diseases increased only by 12.7%, and DALYs from all causes declined by 20.5%. Discussion: The worldwide pandemic of diabetes and hyperglycemia now causes a major and growing disease burden in Brazil, especially in states with greater poverty and a lesser educational level. Conclusion: Diabetes and chronic kidney disease due to diabetes, as well as high fasting plasma glucose in general, currently constitute a major and growing public health problem in Brazil. Actions to date for their prevention and control have been slow considering the magnitude of this burden.

Download Full-text

Serum Secretogranin III Concentrations Were Increased in Subjects with Metabolic Syndrome and Independently Associated with Fasting Plasma Glucose Levels

Journal of Clinical Medicine ◽

10.3390/jcm8091436 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1436 ◽

Cited By ~ 1

Author(s):

Chun-Chung Lin ◽

Kai-Pi Cheng ◽

Hao-Chang Hung ◽

Chung-Hao Li ◽

Ching-Han Lin ◽

...

Keyword(s):

Metabolic Syndrome ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Pancreatic Beta Cells ◽

Secretory Granules ◽

High Sensitivity ◽

Metabolic Parameters ◽

Glucose Levels ◽

Fasting Plasma ◽

High Fasting Plasma Glucose

Secretogranin III (SCG3) plays a crucial role in the biogenesis of secretory granules in endocrine cells, and thus affects glucose homeostasis by regulating insulin secretion by pancreatic beta cells. Insulin resistance and compensatory hyperinsulinemia are hallmarks of metabolic syndrome (MetS). However, the role of SCG3 in MetS remains unclear. Therefore, we investigated the relationship between serum SCG3 levels and metabolic parameters in subjects with and without MetS. This was a case control study, and 295 subjects were recruited. Serum SCG3 concentrations were compared between groups. Associations between SCG3 levels and clinico-metabolic parameters were also examined. We found serum SCG3 levels were higher in the MetS group than non-MetS group (122.6 ± 79.2 vs. 90.6 ± 58.5 nmol/L, p = 0.009). Specifically, elevated SCG3 levels were found in subjects with high fasting plasma glucose (FPG) levels, central obesity, or hypertriglyceridemia. Additionally, MetS was an independent factor of serum SCG3 levels in multivariate linear regression analyses. Moreover, FPG, free fatty acids, and waist circumference were positively associated with serum SCG3 concentrations after adjusting for insulin levels, high-sensitivity C-reactive protein, and cardiovascular risk factors. In conclusion, serum SCG3 concentrations were higher in subjects with MetS and were independently associated with FPG levels.

Download Full-text