Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing

2007 ◽  
Vol 76 (3) ◽  
pp. 222-231 ◽  
Author(s):  
C NG ◽  
F GU ◽  
W PHONG ◽  
Y CHEN ◽  
S LIM ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Antiviral Compound ◽  
Dengue Virus Type 2

In Vitro Antiviral Activity of Pinus merkusii (Pinaceae) Stem Bark and Cone against Dengue Virus Type-2 (DENV-2)

2021 ◽  
pp. 3705-3708
Author(s):  
Arif Nur Muhammad Ansori ◽  
Amaq Fadholly ◽  
Annise Proboningrat ◽  
Suhailah Hayaza ◽  
Raden Joko Kuncoroningrat Susilo ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Dengue Virus ◽  
Virus Type ◽  
Stem Bark ◽  
Endemic Region ◽  
In Vivo Evaluation ◽  
African Green Monkey Kidney ◽  
Antiviral Compound ◽  
Dengue Virus Type 2

Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 μg/mL and 73.78 μg/mL, CC50= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.

Antiviral activity of Faramea bahiensis leaves on dengue virus type-2 and characterization of a new antiviral flavanone glycoside

2017 ◽  
Vol 19 ◽  
pp. 220-225 ◽  
Author(s):  
Adriana C. Nascimento ◽  
Ligia M.M. Valente ◽  
Mário Gomes ◽  
Rodolfo S. Barboza ◽  
Thiago Wolff ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Dengue Virus ◽  
Virus Type ◽  
Flavanone Glycoside ◽  
Dengue Virus Type 2

Establishment and characterization of dengue virus type 2 nonstructural protein 1 specific T cell lines

2010 ◽  
Vol 33 (6) ◽  
pp. e75-e80 ◽  
Author(s):  
Yang Xiao-meng ◽  
Jiang Li-fang ◽  
Tang Yun-xia ◽  
Yin Yue ◽  
Liu Wen-quan ◽  
...  
Keyword(s):  
T Cell ◽  
Dengue Virus ◽  
Cell Lines ◽  
Virus Type ◽  
Nonstructural Protein ◽  
Nonstructural Protein 1 ◽  
T Cell Lines ◽  
Dengue Virus Type 2

scholarly journals Genetic and phenotypic characterization of sylvatic dengue virus type 2 strains

Virology ◽  
2008 ◽  
Vol 377 (2) ◽  
pp. 296-307 ◽  
Author(s):  
Nikos Vasilakis ◽  
Eric B. Fokam ◽  
Christopher T. Hanson ◽  
Ethan Weinberg ◽  
Amadou A. Sall ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Phenotypic Characterization ◽  
Dengue Virus Type 2

Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2

2006 ◽  
Vol 139 (3) ◽  
pp. 607-614 ◽  
Author(s):  
Chie Aoki ◽  
Kazuya I.P.J. Hidari ◽  
Saki Itonori ◽  
Akihiro Yamada ◽  
Naonori Takahashi ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Mammalian Cells ◽  
Identification And Characterization ◽  
Dengue Virus Type 2

scholarly journals Clinical and Epidemiological Characterization of the First Recognized Outbreak of Dengue Virus-Type 2 in Mozambique, 2014

2016 ◽  
Vol 94 (2) ◽  
pp. 413-416 ◽  
Author(s):  
Marilia Massangaie ◽  
Janusz Paweska ◽  
Celia Chirindza ◽  
Jacqueline Weyer ◽  
Eduardo Samo Gudo ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Epidemiological Characterization ◽  
Dengue Virus Type 2

scholarly journals Characterization of Dengue Virus Type 2: New Insights on the 2010 Brazilian Epidemic

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11811 ◽  
Author(s):  
Camila Malta Romano ◽  
Andréia Manso de Matos ◽  
Evaldo Stanislau A. Araújo ◽  
Lucy Santos Villas-Boas ◽  
Wanessa Cardoso da Silva ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Dengue Virus Type 2
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