Poster 36: Cognitive Functioning in Older Adults Over Time: Effect of Traumatic Brain Injury and APOE ε4 Allele Status

Abstract Objective We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI). Method Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4–). The Neurobehavioral Symptom Inventory (NSI) was the primary outcome measure, from which a total score was derived, as well as three symptom clusters (somatic, cognitive, and affective). Results ANCOVAs showed a significant main effect of ε4 genotype on the NSI total score and somatic symptom cluster after adjusting for posttraumatic stress symptoms and mTBI history (p = .019–.028, ηp2 = .064–.073), such that ε4+ Veterans endorsed significantly greater symptoms than ε4– Veterans. Conclusions Our findings suggest that genetic risk may help to explain the poorer long-term outcomes often observed in this population.

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Poster 23: Cognitive Functioning and Community Integration in Older Adults With Traumatic Brain Injury

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2008.08.126 ◽

2008 ◽

Vol 89 (10) ◽

pp. e34

Author(s):

Stacey Belkonen ◽

Wayne Gordon ◽

Ren Krinick ◽

Joshua Cantor ◽

Teresa Ashman ◽

...

Keyword(s):

Older Adults ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Functioning ◽

Community Integration

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ROLE OF APOE-ε4 ALLELE IN RECOVERY FROM TRAUMATIC BRAIN INJURY: STUDY IN A TERTIARY CLINIC IN KOLKATA.

International Journal of Advanced Research ◽

10.21474/ijar01/2273 ◽

2016 ◽

Vol 4 (11) ◽

pp. 1780-1786

Author(s):

Nikhil Talathi ◽

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Apoe Ε4 ◽

Ε4 Allele

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Measuring Change Over Time: A Systematic Review of Evaluative Measures of Cognitive Functioning in Traumatic Brain Injury

Frontiers in Neurology ◽

10.3389/fneur.2019.00353 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 6

Author(s):

Andrea D'Souza ◽

Shirin Mollayeva ◽

Nicole Pacheco ◽

Fiza Javed ◽

Angela Colantonio ◽

...

Keyword(s):

Systematic Review ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Functioning ◽

Change Over Time ◽

Measuring Change ◽

Over Time

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A Comparison of Cognitive Functioning in Older Adults With and Without Traumatic Brain Injury

Journal of Head Trauma Rehabilitation ◽

10.1097/01.htr.0000319930.69343.64 ◽

2008 ◽

Vol 23 (3) ◽

pp. 139-148 ◽

Cited By ~ 32

Author(s):

Teresa A. Ashman ◽

Joshua B. Cantor ◽

Wayne A. Gordon ◽

Amanda Sacks ◽

Lisa Spielman ◽

...

Keyword(s):

Older Adults ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Functioning

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Cognitive control constrains memory attributions

Behavioral and Brain Sciences ◽

10.1017/s0140525x19001869 ◽

2019 ◽

Vol 42 ◽

Author(s):

Colleen M. Kelley ◽

Larry L. Jacoby

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

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