3D printed tricalcium phosphate-bioglass scaffold with gyroid structure enhance bone ingrowth in challenging bone defect treatment

2021 ◽  
Vol 25 ◽  
pp. 101166
Author(s):  
Hao Zhu ◽  
Meng Li ◽  
Xiaolong Huang ◽  
Dahu Qi ◽  
Liebert Parreiras Nogueira ◽  
...  
Keyword(s):  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Bone Ingrowth ◽  
3D Printed ◽  
Bone Defect Treatment

3D printed polycaprolactone/beta-tricalcium phosphate/magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing the large bone defect

2021 ◽  
Author(s):  
Ziyue Peng ◽  
Chengqiang Wang ◽  
Chun Liu ◽  
Haixia Xu ◽  
Yihan Wang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Large Bone Defect ◽  
Beta Tricalcium Phosphate ◽  
Defect Area ◽  
3D Printed ◽  
Magnesium Peroxide ◽  
Large Bone ◽  
Phosphate Magnesium

Fabricate a MgO2-contained scaffold by 3D printing to improve ischemia and hypoxia in bone defect area.

scholarly journals In Vivo Reconstruction of the Acetabular Bone Defect by the Individualized Three-Dimensional Printed Porous Augment in a Swine Model

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Jun Fu ◽  
Yi Xiang ◽  
Ming Ni ◽  
Xiaojuan Qu ◽  
Yonggang Zhou ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Elastic Modulus ◽  
Bone Defect ◽  
Bone Ingrowth ◽  
Structural Parameters ◽  
Three Dimensional ◽  
Acetabular Bone ◽  
Acetabular Bone Defect ◽  
3D Printed ◽  
Matching Degree

Background and Purpose. This study established an animal model of the acetabular bone defect in swine and evaluated the bone ingrowth, biomechanics, and matching degree of the individualized three-dimensional (3D) printed porous augment. Methods. As an acetabular bone defect model created in Bama miniswine, an augment individually fabricated by 3D print technique with Ti6Al4V powders was implanted to repair the defect. Nine swine were divided into three groups, including the immediate biomechanics group, 12-week biomechanics group, and 12-week histological group. The inner structural parameters of the 3D printed porous augment were measured by scanning electron microscopy (SEM), including porosity, pore size, and trabecular diameter. The matching degree between the postoperative augment and the designed augment was assessed by CT scanning and 3D reconstruction. In addition, biomechanical properties, such as stiffness, compressive strength, and the elastic modulus of the 3D printed porous augment, were measured by means of a mechanical testing machine. Moreover, bone ingrowth and implant osseointegration were histomorphometrically assessed. Results. In terms of the inner structural parameters of the 3D printed porous augment, the porosity was 55.48 ± 0.61 % , pore size 319.23 ± 25.05   μ m , and trabecular diameter 240.10 ± 23.50   μ m . Biomechanically, the stiffness was 21464.60 ± 1091.69   N / mm , compressive strength 231.10 ± 11.77   MPa , and elastic modulus 5.35 ± 0.23   GPa , respectively. Furthermore, the matching extent between the postoperative augment and the designed one was up to 91.40 ± 2.83 % . Besides, the maximal shear strength of the 3D printed augment was 929.46 ± 295.99   N immediately after implantation, whereas the strength was 1521.93 ± 98.38   N 12 weeks after surgery ( p = 0.0302 ). The bone mineral apposition rate (μm per day) 12 weeks post operation was 3.77 ± 0.93   μ m / d . The percentage bone volume of new bone was 22.30 ± 4.51 % 12 weeks after surgery. Conclusion. The 3D printed porous Ti6Al4V augment designed in this study was well biocompatible with bone tissue, possessed proper biomechanical features, and was anatomically well matched with the defect bone. Therefore, the 3D printed porous Ti6Al4V augment possesses great potential as an alternative for individualized treatment of severe acetabular bone defects.

A 3D printed Ga containing scaffold with both anti-infection and bone homeostasis-regulating properties for the treatment of infected bone defects

2021 ◽  
Author(s):  
Minqi Wang ◽  
Yiqi Yang ◽  
Guanghao Chi ◽  
Kai Yuan ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defects ◽  
Bone Homeostasis ◽  
Dual Functional ◽  
3D Printed ◽  
Bone Defect Treatment

A dual-functional 3D printed scaffold with both anti-infection and bone homeostasis-regulating properties for infected bone defect treatment.

Influence of random and designed porosities on 3D printed tricalcium phosphate-bioactive glass scaffolds

2021 ◽  
Vol 40 ◽  
pp. 101895 ◽  
Author(s):  
Susmita Bose ◽  
Arjak Bhattacharjee ◽  
Dishary Banerjee ◽  
Aldo R. Boccaccini ◽  
Amit Bandyopadhyay
Keyword(s):  
Bioactive Glass ◽  
Tricalcium Phosphate ◽  
3D Printed

scholarly journals Clinical study of 3D printed personalized prosthesis in the treatment of bone defect after pelvic tumor resection

2021 ◽  
Vol 29 ◽  
pp. 163-169
Author(s):  
Lin Xu ◽  
Hao Qin ◽  
Jia Tan ◽  
Zhilin Cheng ◽  
Xiang Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Bone Defect ◽  
Tumor Resection ◽  
Pelvic Tumor ◽  
3D Printed

scholarly journals Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

2021 ◽  
Vol 6 (11) ◽  
pp. 3659-3670
Author(s):  
Teng Zhang ◽  
Qingguang Wei ◽  
Hua Zhou ◽  
Zehao Jing ◽  
Xiaoguang Liu ◽  
...  
Keyword(s):  
Bone Defect ◽  
Three Dimensional ◽  
Large Bone Defect ◽  
Bone Interface ◽  
Fusion Concept ◽  
Bone Defect Treatment ◽  
Large Bone

A pilot study: Alternative biomaterials in critical sized bone defect treatment

Injury ◽  
2018 ◽  
Vol 49 (3) ◽  
pp. 523-531 ◽  
Author(s):  
Magdalena Tarchala ◽  
Victor Engel ◽  
Jake Barralet ◽  
Edward J. Harvey
Keyword(s):  
Pilot Study ◽  
Bone Defect ◽  
Bone Defect Treatment

3D-printed Poly-Lactic Co-Glycolic Acid (PLGA) scaffolds in non-critical bone defects impede bone regeneration in rabbit tibia bone

2021 ◽  
pp. 1-7
Author(s):  
Jin Xi Lim ◽  
Min He ◽  
Alphonsus Khin Sze Chong
Keyword(s):  
Computed Tomography ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Volume Ratio ◽  
Bone Defects ◽  
Control Group ◽  
Micro Computed Tomography ◽  
Rabbit Tibia ◽  
3D Printed ◽  
Critical Bone Defects

BACKGROUND: An increasing number of bone graft materials are commercially available and vary in their composition, mechanism of action, costs, and indications. OBJECTIVE: A commercially available PLGA scaffold produced using 3D printing technology has been used to promote the preservation of the alveolar socket after tooth extraction. We examined its influence on bone regeneration in long bones of New Zealand White rabbits. METHODS: 5.0-mm-diameter circular defects were created on the tibia bones of eight rabbits. Two groups were studied: (1) control group, in which the bone defects were left empty; (2) scaffold group, in which the PLGA scaffolds were implanted into the bone defect. Radiography was performed every two weeks postoperatively. After sacrifice, bone specimens were isolated and examined by micro-computed tomography and histology. RESULTS: Scaffolds were not degraded by eight weeks after surgery. Micro-computed tomography and histology showed that in the region of bone defects that was occupied by scaffolds, bone regeneration was compromised and the total bone volume/total volume ratio (BV/TV) was significantly lower. CONCLUSION: The implantation of this scaffold impedes bone regeneration in a non-critical bone defect. Implantation of bone scaffolds, if unnecessary, lead to a slower rate of fracture healing.

scholarly journals Reconstruction of Severe Acetabular Bone Defect with 3D Printed Ti6Al4V Augment: A Finite Element Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jun Fu ◽  
Ming Ni ◽  
Jiying Chen ◽  
Xiang Li ◽  
Wei Chai ◽  
...  
Keyword(s):  
Finite Element ◽  
Yield Strength ◽  
Bone Defect ◽  
Cancellous Bone ◽  
Acetabular Bone ◽  
Fea Model ◽  
Acetabular Bone Defect ◽  
3D Printed ◽  
Von Mises ◽  
Von Mises Stresses

Purpose. The purpose of this study was to establish the finite element analysis (FEA) model of acetabular bone defect reconstructed by 3D printed Ti6Al4V augment and TM augment and further to analyze the stress distribution and clinical safety of augments, screws, and bones.Methods. The FEA model of acetabular bone defect reconstructed by 3D printed Ti6Al4V augment was established by the CT data of a patient with Paprosky IIIA defect. The von Mises stresses of augments, screws, and bones were analyzed by a single-legged stance loading applied in 3 increments (500 N, 2000 N, and 3000 N).Results. The peak von Mises stresses under the maximal loading in the 3D printed augments, screws, and cortical bone were less than the yield strength of the corresponding component. However, the peak stress in the bone was greater than the yield strength of cancellous bone under walking or jogging loading. And under the same loading, the peak compressive and shear stresses in bone contact with TM augment were larger than these with 3D printed augment.Conclusions. The FEA results show that all the components will be intact under single-legged standing. However, partial cancellous bone contacted with 3D printed augment and screws will lose efficacy under walking or jogging load. So we recommend that patients can stand under full bearing, but can not walk or jog immediately after surgery.

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