Long-term exposure to high-protein diet or high-fat diet have opposite effects on vagal afferent sensitivity to luminal macronutrients, ip cholecystokinin and serotonin

Appetite ◽  
2007 ◽  
Vol 49 (1) ◽  
pp. 316 ◽  
Author(s):  
W. Nefti ◽  
N. Darcel ◽  
G. Fromentin ◽  
D. Tomé
Keyword(s):  
High Fat Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat ◽  
Vagal Afferent

scholarly journals Biochemical aspects of malabsorption in marasmus: effect of dietary rehabilitation

1985 ◽  
Vol 54 (3) ◽  
pp. 567-575 ◽  
Author(s):  
H. C. Mehta ◽  
A. S. Saini ◽  
Harjit Singh ◽  
P. S. Dhatt
Keyword(s):  
Total Energy ◽  
High Fat Diet ◽  
High Protein Diet ◽  
High Carbohydrate Diet ◽  
High Protein ◽  
Protein Diet ◽  
Duodenal Juice ◽  
High Fat ◽  
Carbohydrate Diet ◽  
High Carbohydrate

1. Sixty marasmic children were investigated for the absorption of xylose, proteins and fats. Their duodenal juice samples were also analysed for bile salts and microflora.2. The marasmic children were then studied in three groups of twenty by allocating them to three different dietary schedules: a high-protein diet (30% of the total energy from protein), a high-fat diet (40% of the total energy from fat) and a high-carbohydrate diet (70% of the total energy from carbohydrate) for 2 weeks and the previous measurements repeated.3. Whereas the high-fat diet resulted in improved fat absorption, along with an increase in total and conjugated bile acids, and the high-carbohydrate diet led to improved xylose absorption, the diet rich in protein resulted in an improvement in the absorption of all three dietary ingredients. It appears that a high-protein diet improves the overall absorption process by improving the intestinal environment as a whole, while high-carbohydrate and high-fat diets bring about adaptive changes related to the respective absorptive processes.

scholarly journals Glucose Tolerance in Response to a High-Fat Diet Is Improved by a High-Protein Diet

Obesity ◽  
2012 ◽  
Vol 20 (9) ◽  
pp. 1859-1865 ◽  
Author(s):  
Mary A. Honors ◽  
Sara L. Hargrave ◽  
Kimberly P. Kinzig
Keyword(s):  
Glucose Tolerance ◽  
High Fat Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat

scholarly journals Effect of the nature and amount of dietary energy on lipid composition of rat gingival tissue

1983 ◽  
Vol 49 (2) ◽  
pp. 187-192
Author(s):  
Salil K. Das ◽  
Munalula L. Elliott ◽  
Halifax C. King
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Gingival Tissue ◽  
Dietary Energy ◽  
High Fat ◽  
High Carbohydrate ◽  
Fat Diets

1. The effect of the nature and amount of dietary energy on the lipid composition of rat gingival tissue was studied. Male weanling rats were given one of three iso-energetic diets: high-carbohydrate, high-protein and extremely high-protein, or a fourth high-fat diet, for 49 d.2. The high-carbohydrate, extremely high-protein and high-fat diets caused significant increases in the gingival levels of total lipids compared with the normal-protein diet. These increases in total lipids were due primarily to increases in the levels of triglycerides and cholesterol esters. There were no significant differences in the fatty acid compositions of either non-polar or polar lipids among rats given the high-carbohydrate diet and those given the high-protein diet.3. A comparison of the fatty acid composition of lipids of rats given the extremely high-protein diet and the other two iso-energetic diets revealed that the proportion of palmitic acid was higher and the proportion of oleic acid was lower in animals given the extremely high-protein diet than in animals given the other two diets. Compared with the three iso-energetic low-fat diets, the high-fat diet caused decreases in the proportion of palmitic and palmitoleic acids and increases in the proportion of linoleic, arachidonic and docosapentaenoic acids in total fatty acids of both non-polar and polar lipids. It should be noted that the high-fat diet contained a high proportion of linoleic acid and it is expected that this diet would raise the 18:2 fatty acid content of the lipids and also would raise the 20:4 and 22:5 levels as 18:2 is an essential fatty acid and will, with its metabolites, be directly incorporated into tissue lipids.

Su1881 High Protein Diet Improves Meal Pattern and Response to Cholecystokinin (CCK) in High Fat Diet-Induced Obese Rats

2015 ◽  
Vol 148 (4) ◽  
pp. S-541-S-542
Author(s):  
Lixin Wang ◽  
Joseph R. Reeve ◽  
Joseph R. Pisegna ◽  
Yvette Tache
Keyword(s):  
High Fat Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat ◽  
Meal Pattern ◽  
Obese Rats

scholarly journals Long Term Metabolic and Health Effects of a Low-Carbohydrate, High-Fat, High-Protein Diet in Mus musculus: A Nineteen Week Longitudinal Study

2005 ◽  
Vol 4 (1) ◽  
Author(s):  
Donald Harris ◽  
Christopher Bell ◽  
Misty Retzlaff ◽  
Stephanie Toering ◽  
Elizabeth Wurdak ◽  
...  
Keyword(s):  
Health Effects ◽  
High Protein Diet ◽  
Liver Glycogen ◽  
High Protein ◽  
Protein Diet ◽  
Control Group ◽  
Tissue Analysis ◽  
High Fat ◽  
Low Carbohydrate

This study was designed to investigate the long-term metabolic adaptations and health effects of a low-carbohydrate, high-fat/protein diet in mice. One-month-old male ICR mice were fed a control, conventional high-carbohydrate diet (n=21) or an experimental low-carbohydrate, high-fat, high-protein diet (n=20). One pair of mice per group was euthanized at two-week intervals for five months for tissue analysis. Basic metabolic data, body and tissue weights, blood and plasma metabolite and lipid profiles, liver glycogen and protein content, and liver serine dehydratase and glucose-6-phosphate dehydrogenase activities were analyzed. The low-carbohydrate group gained significantly more weight (p<0.005 after 4 weeks) than the normally growing control group. Although ketosis was initially stimulated in the low-carbohydrate group, enzyme and tissue analysis suggest that gluconeogenic activity was sufficient to alleviate the effects of severe dietary carbohydrate restriction and allow for glucose metabolism close to that demonstrated in the control group.

scholarly journals Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

2013 ◽  
Vol 10 (1) ◽  
pp. 26 ◽  
Author(s):  
Rebeca Lugaresi ◽  
Marco Leme ◽  
Vítor de Salles Painelli ◽  
Igor Murai ◽  
Hamilton Roschel ◽  
...  
Keyword(s):  
Kidney Function ◽  
Creatine Supplementation ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals Promoting Effect of a High-Fat/High-Protein Diet in DMBA-Induced Ductal Pancreatic Cancer in Rats

2001 ◽  
Vol 233 (5) ◽  
pp. 688-695 ◽  
Author(s):  
Kaspar Z’graggen ◽  
Andrew L. Warshaw ◽  
Jens Werner ◽  
Fiona Graeme-Cook ◽  
Ramon E. Jimenez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat ◽  
Promoting Effect ◽  
Ductal Pancreatic Cancer

scholarly journals High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

2020 ◽  
Vol 21 (6) ◽  
pp. 2147 ◽  
Author(s):  
Fan Hong ◽  
Aijuan Zheng ◽  
Pengfei Xu ◽  
Jialin Wang ◽  
Tingting Xue ◽  
...  
Keyword(s):  
Animal Model ◽  
Metabolic Diseases ◽  
High Protein Diet ◽  
Serum Urate ◽  
Dietary Factors ◽  
High Protein ◽  
Protein Diet ◽  
Positive Effects ◽  
Biological Studies

Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension. Overproduction of urate is one of the main reasons for hyperuricemia, and dietary factors including seafoods, meats, and drinking are contributed to the development of it. However, the lack of a suitable animal model for urate metabolism is one of the main reasons for the delay and limitations of hyperuricemia research. Combining evolutionary biological studies and clinical studies, we conclude that chicken is a preferred animal model for hyperuricemia. Thus, we provided chickens a high-protein diet (HPD) to evaluate the changes in the serum urate levels in chickens. In our study, the HPD increased the serum urate level and maintained it at a long-term high level in chickens. Long-term high serum urate levels induced an abnormal chicken claw morphology and the precipitation of monosodium urate (MSU) in joint synovial fluid. In addition, a long-term HPD also decreased the glomerular filtration rate and induced mild renal injury. Most importantly, allopurinol and probenecid displayed the positive effects in decreasing serum urate and then attenuated hyperuricemia in chicken model. These findings provide a novel model for hyperuricemia and a new opportunity to further investigate the effects of long-term hyperuricemia on other metabolic diseases.

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