scholarly journals Simultaneous effects of nutritional and environmental factors on growth and flesh quality of Perca fluviatilis using a fractional factorial design study

Aquaculture ◽  
2007 ◽  
Vol 273 (1) ◽  
pp. 50-63 ◽  
Author(s):  
Jean-Noel Gardeur ◽  
Nicolas Mathis ◽  
Andre Kobilinsky ◽  
Jean Brun-Bellut
Keyword(s):  
Environmental Factors ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Perca Fluviatilis ◽  
Fractional Factorial ◽  
Design Study ◽  
Flesh Quality

Influence of Environmental Factors and Adjuvants on the Foliar Penetration of Acifluorfen in Velvetleaf (Abutilon theophrasti): An Analysis Using the Fractional Factorial Design

Weed Science ◽  
1988 ◽  
Vol 36 (6) ◽  
pp. 824-829 ◽  
Author(s):  
Gary L. Willingham ◽  
Linda L. Graham
Keyword(s):  
Soil Moisture ◽  
Relative Humidity ◽  
Environmental Factors ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Abutilon Theophrasti ◽  
Fractional Factorial ◽  
High Penetration ◽  
Growth Chambers ◽  
Design Experiments

Two-level fractional factorial design experiments were conducted in growth chambers to determine the influence of environmental factors and adjuvants on the foliar penetration of the sodium salt of acifluorfen in velvetleaf. Relative humidity (RH) was found to have the greatest effect on penetration. Temperature was the second most important factor. Although soil moisture significantly affected penetration, this effect was much less than that produced by RH and temperature. Diammonium phosphate (DAP) was the most effective adjuvant tested. The use of DAP at 1.12 kg/ha significantly increased penetration. The effect of DAP was less than either RH or temperature. Oxysorbic (5 POE) surfactant also significantly increased penetration. Glycerol and oxtoxynol (7 to 8 POE) surfactant had no effect on penetration. In separate experiments, acifluorfen penetration at low and high RH and with the addition of DAP was measured to verify these results. Acifluorfen penetration into velvetleaf increased approximately ninefold with changes in RH from low to high. Penetration increased sevenfold when DAP was added. DAP was by far the most effective adjuvant increasing acifluorfen penetration into velvetleaf under conditions of low RH. Oxysorbic (5 POE) surfactant slightly increased penetration under these conditions.

scholarly journals Fractional Factorial Design Study on the Performance of GAC-Enhanced Electrocoagulation Process Involved in Color Removal from Dye Solutions

Materials ◽  
2013 ◽  
Vol 6 (7) ◽  
pp. 2723-2746 ◽  
Author(s):  
Marius Secula ◽  
Igor Cretescu ◽  
Benoit Cagnon ◽  
Liliana Manea ◽  
Corneliu Stan ◽  
...  
Keyword(s):  
Factorial Design ◽  
Fractional Factorial Design ◽  
Fractional Factorial ◽  
Color Removal ◽  
Design Study ◽  
Electrocoagulation Process ◽  
Dye Solutions

scholarly journals Development of the Composition and Technology of New Neuroprotective Drug Tablets Using Fractional Factorial Design

2020 ◽  
Vol 9 (1) ◽  
pp. 18-22
Author(s):  
O. A. Terenteva ◽  
E. V. Flisyuk ◽  
D. Yu. Ivkin ◽  
I. A. Narkevich
Keyword(s):  
Factorial Design ◽  
Fractional Factorial Design ◽  
Desirability Function ◽  
Neuroprotective Effect ◽  
Compressibility Factor ◽  
Fractional Factorial ◽  
Calcium Stearate ◽  
Technological Properties ◽  
Maize Starch

Introduction. The creating an effective and safe domestic neuroprotective medicines with a complex of pleiotropic effects realized through specific orphan receptors (SUCNR1, HCA2) of glial cells, is a pressing problem of modern pharmacology and a promising possibility of pharmacotherapy of brain injury and cerebrovascular diseases. Ideally, the medicine should helps restore lost cognitive functions and physical performance after damage to the central nervous system, and its use should improve the quality of life of patients and reduce the risk of complications.Aim. To develop composition and technology of a new medicine tablets with neuroprotective effect, using fractional factorial design of experiment and the Harrington desirability function.Materials and methods. The shape and size of particles, physicochemical (solubility, melting point) and technological properties (bulk density, compressibility factor, fractional composition, hygroscopicity) of the pharmaceutical substance of DEAE derivative were studied according to the methods described in the State Pharmacopoeia of the Russian Federation (14th edition). A three-factor fractional plan based on the 4 × 4 Latin square design for selection a scientifically based composition of solid dosage form was chosen. 16 experiments to test the significance of the factors were carried out. The tablets obtained according to the planning matrix were investigated for disintegration; tablet crush resistance, friability, and hygroscopicity. To optimize the quality of the tablets, the generalized Harrington desirability function was used.Results and discussion. The study of the physicochemical and technological properties of the DEAE derivative substance showed that it is a highly hygroscopic, amorphous, white or pale yellow, odourless powder, prone to the formation of agglomerates. The powder is very easily soluble in water. Taking into account the values of the general desirability function, the best result was shown by sample № 4 consisting of mannitol, calcium stearate, and partially pregelatinized maize starch.Conclusion. The physicochemical and technological properties of the DEAE derivative were studied. The DEAE derivative is a highly hygroscopic substance. Via the method of mathematical planning of the experiment the composition of DEAE derivative tablets was selected and scientifically grounded: DEAE derivative 60 mg, mannitol, partially pregelatinized maize starch, calcium stearate. The average tablet weight is 300 mg. The parameters of pressing tablets were selected.

scholarly journals Fractional Factorial Design Study for the Extraction of Cannabinoids from CBD-Dominant Cannabis Flowers by Supercritical Carbon Dioxide

Processes ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 93
Author(s):  
Sadia Qamar ◽  
Yady J. M. Torres ◽  
Harendra S. Parekh ◽  
James Robert Falconer
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Organic Solvent ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Fractional Factorial ◽  
Extraction Time ◽  
High Yield ◽  
Design Study ◽  
Supercritical Carbon

The optimization of the supercritical fluid extraction (SFE) of cannabinoids, using supercritical carbon dioxide (scCO2), was investigated in a fractional factorial design study. It is hypothesized that four main parameters (temperature, pressure, dry flower weight, and extraction time) play an important role. Therefore, these parameters were screened at predetermined low, medium, and high relative levels. The density of scCO2 was used as a factor for the extraction of cannabinoids by changing the pressure and temperature. The robustness of the mathematical model was also evaluated by regression analysis. The quantification of major (cannabidiol (CBD), cannabidiolic acid (CBDA), delta 9-tetrahydrocannabinol (Δ9-THC), delta 8-tetrahydrocannabinol (Δ8-THC), and delta 9-tetrahydrocannabinol acid (THCA-A)) and minor (cannabidivann (CBDV), tetrahydrocannabivann (THCV), cannabigerolic acid (CBG), cannabigerol (CBGA), cannabinol (CBN), and cannabichomere (CBC)) cannabinoids in the scCO2 extract was performed by RP-HPLC analysis. From the model response, it was identified that long extraction time is a significant parameter to obtain a high yield of cannabinoids in the scCO2 extract. Higher relative concentrations of CBD(A) (0.78 and 2.41% w/w, respectively) and THC(A) (0.084 and 0.048% w/w, respectively) were found when extraction was performed at high relative pressures and temperatures (250 bar and 45 °C). The higher yield of CBD(A) compared to THC(A) can be attributed to the extract being a CBD-dominant cannabis strain. The study revealed that conventional organic solvent extraction, e.g., ethanol gives a marginally higher yield of cannabinoids from the extract compared to scCO2 extraction. However, scCO2 extraction generates a cleaner (chlorophyll-free) and organic solvent-free extract, which requires less downstream processing, such as purification from waxes and chlorophyll.

Optimization of PES Nanocomposite Membrane Preparation Using Statistical Analysis and Experimental Design

2019 ◽  
Author(s):  
Yasin Orooji ◽  
Fatemeh Noorisafa ◽  
Nahid Imami ◽  
Amir R. Chaharmahali
Keyword(s):  
Statistical Analysis ◽  
Experimental Design ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Fractional Factorial ◽  
Nanocomposite Membrane ◽  
Membrane Preparation ◽  
Membrane Fabrication

<p>Using experimental design and statistical analysis (½ Fractional Factorial Design), this study investigates the effect of different parameters in the membrane fabrication on the performance of nanocomposite PES/TiO<sub>2</sub> membrane. </p>

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