Synthesis, spectroscopic characterization and in vitro antimicrobial studies of Schiff base ligand, H2L derived from glyoxalic acid and 1,8-diaminonaphthalene and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

The metal(II) complexes were synthesized by addition of corresponding MCl2 (M = Mn2+, Ni2+, Cu2+ and Zn2+) with 1,2-bis(1H-pyrrol-2-ylmethylene)diazane in methanol. The ligand acts as a bidentate as confirmed from the mass, IR, UV, NMR and EPR spectral studies. The Schiff base ligand forms hexa-coordinated complexes having octahedral geometry for Mn(II), Ni(II), Zn(II) and Cu(II) complexes. The metal complexes showed an excellent antimicrobial activity spectrum in vitro against both Gram-negative (Klebsiella pneumoniae and Acinetobacter baumannii), Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and human pathogenic bacteria isolates. To find the binding affinity with protein BSA kinase, for that molecular docking studies were also carried for all the four synthesized metal(II) complexes. The anticancer activity of the synthesized metal(II) complexes was also screened against the three human tumor cell lines MCF7 human breast adenocarcinoma cell line, CaSki human caucasian cervical epidermoid carcinoma and HCT116 human colon cancer cell lines. The present study showed that Zn(II) complex showed potent inhibition by the ratio of 80% as compared to the inhibition in the normal cells (L-6).

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CYTOTOXIC, ANTITUMOR AND ANTIMICROBIAL STUDIES OF AN OXYGEN AND NITROGEN DONOR, NOVEL SCHIFF BASE LIGAND, ACETOACETANILIDE-(1,2-ETHYLENEDIIMINE) ETHYLACETOACETATE AND ITS TRANSITION METAL COMPLEXES

International Research Journal of Pharmacy ◽

10.7897/2230-8407.0810201 ◽

2017 ◽

Vol 8 (10) ◽

pp. 160-166

Author(s):

Subin Kumar K ◽

Priya C Varma ◽

Reena V N ◽

K K Aravindakshan

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Antimicrobial Studies ◽

Nitrogen Donor

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Zr(IV), La(III), and Ce(IV) Chelates with 2-[(4-[(Z)-1-(2-Hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol: Synthesis, Spectroscopic Characterization, and Antimicrobial Studies

Advances in Chemistry ◽

10.1155/2015/987420 ◽

2015 ◽

Vol 2015 ◽

pp. 1-15 ◽

Cited By ~ 2

Author(s):

M. M. El-ajaily ◽

H. A. Abdullah ◽

Ahmed Al-janga ◽

E. E. Saad ◽

A. A. Maihub

Keyword(s):

Schiff Base ◽

Spectral Data ◽

Schiff Base Ligand ◽

Active Sites ◽

Antimicrobial Agents ◽

Spectroscopic Characterization ◽

Metal Chelates ◽

Molar Ratio ◽

Bacterial Strains ◽

Activity Data

La(III), Zr(IV), and Ce(IV) chelates of 2-[(4-[(Z)-1-(2-hydroxyphenyl)ethylidene]aminobutyl)-ethanimidoyl]phenol were synthesized and characterized by using several physical techniques. The Schiff base was obtained by refluxing of o-hydroxyacetophenone with 1,4-butanediamine in 2 : 1 molar ratio. The CHN elemental analysis results showed the formation of the Schiff base and the chelates has been found to be in 1 : 1 [M : L] ratio. The molar conductance measurements revealed that all the chelates are nonelectrolytes. Structural elucidations of the ligand and its chelates were based on compatible analytical and spectroscopic evidences. The infrared spectral data revealed that the Schiff base coordinates to the metal ions through active sites which are –OH and –C=N groups. According to the electronic spectral data, an octahedral geometry was proposed for the chelates. The synthesized ligand and its metal chelates were screened for their antimicrobial activity against two Gram negative (Escherichia coli, Salmonella kentucky) and two Gram positive (Lactobacillus fermentum, Streptococcus faecalis) bacterial strains, unicellular fungi (Fusarium solani), and filamentous fungi (Aspergillus niger). The activity data showed that the metal chelates have antibacterial and antifungal activity more than the parent Schiff base ligand against one or more bacterial or fungi species. The results also indicated that the metal chelates are higher sensitive antimicrobial agents as compared to the Schiff base ligand.

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