Salivary antioxidant capacity of children with severe early childhood caries before and after complete dental rehabilitation

2018 ◽  
Vol 95 ◽  
pp. 165-169 ◽  
Author(s):  
Ghazi S. AlAnazi ◽  
Sharat Chandra Pani ◽  
Hana J. AlKabbaz
Keyword(s):  
Early Childhood ◽  
Antioxidant Capacity ◽  
Early Childhood Caries ◽  
Before And After ◽  
Dental Rehabilitation ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

scholarly journals Microbiota of Severe Early Childhood Caries before and after Therapy

2011 ◽  
Vol 90 (11) ◽  
pp. 1298-1305 ◽  
Author(s):  
A.C.R. Tanner ◽  
R.L. Kent ◽  
P. Lif Holgerson ◽  
C.V. Hughes ◽  
C.Y. Loo ◽  
...  
Keyword(s):  
Early Childhood ◽  
Early Childhood Caries ◽  
Lower Detection ◽  
Before And After ◽  
Dietary Component ◽  
Prevotella Species ◽  
Post Therapy ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Severe early childhood caries (ECC) is difficult to treat successfully. This study aimed to characterize the microbiota of severe ECC and evaluate whether baseline or follow-up microbiotas are associated with new lesions post-treatment. Plaque samples from 2- to 6-year-old children were analyzed by a 16S rRNA-based microarray and by PCR for selected taxa. Severe-ECC children were monitored for 12 months post-therapy. By microarray, species associated with severe-ECC (n = 53) compared with caries-free (n = 32) children included Slackia exigua (p = 0.002), Streptococcus parasanguinis (p = 0.013), and Prevotella species (p < 0.02). By PCR, severe-ECC-associated taxa included Bifidobacteriaceae (p < 0.001), Scardovia wiggsiae (p = 0.003), Streptococcus mutans with bifidobacteria (p < 0.001), and S. mutans with S. wiggsiae (p = 0.001). In follow-up, children without new lesions (n = 36) showed lower detection of taxa including S. mutans, changes not observed in children with follow-up lesions (n = 17). Partial least-squares modeling separated the children into caries-free and two severe-ECC groups with either a stronger bacterial or a stronger dietary component. We conclude that several species, including S. wiggsiae and S. exigua, are associated with the ecology of advanced caries, that successful treatment is accompanied by a change in the microbiota, and that severe ECC is diverse, with influences from selected bacteria or from diet.

scholarly journals Comparative Evaluation and Correlation of Salivary Total Antioxidant Capacity and Salivary pH in Caries-free and Severe Early Childhood Caries Children

2015 ◽  
Vol 16 (3) ◽  
pp. 234-237 ◽  
Author(s):  
Meenakshi Nankar ◽  
Hrishikesh Walimbe ◽  
Mohammed Nadeem Ahmed Bijle ◽  
Sneha Muchandi ◽  
Srishti Chaturvedi ◽  
...  
Keyword(s):  
Early Childhood ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Comparative Evaluation ◽  
Early Childhood Caries ◽  
Group I ◽  
Salivary Ph ◽  
Total Antioxidant ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

ABSTRACT Background Dental caries is a major problem in preschool children. The contribution of saliva in providing defense during caries process is of primary importance. pH buffer capacity through bicarbonate, phosphate and protein buffer systems have universal acceptance as a caries defense mechanism. Antioxidant capacity of saliva can constitute a first line of defense against chronic degenerative diseases including dental caries. Till date, no study is presented with salivary antioxidant capacity of younger children affected with severe early childhood caries with its salivary pH correlation. Hence, this study was carried out to compare, evaluate and correlate the salivary total antioxidant capacity (TAC) and salivary pH of children with caries-free and severe early childhood caries. Materials and methods Fifty children from ages 3 to 5 years divided into two study groups had undergone screening. Group I (n = 25) with severe early childhood caries (S-ECC) and group II (n = 25) who were caries free. Unstimulated whole saliva of subjects were in the collection during the study by draining method. Salivary pH determination of saliva samples was done using pH indicator paper strips. The TAC was done using an antioxidant assay with the help of a spectrophotometer at wavelength 532 nm. The means of salivary pH and TAC were subjected to analysis using unpaired student ‘t’ test and correlation was determined using Pearsons correlation coefficient analysis. Results Mean salivary pH was higher in group II (7.46 ± 0.37). Mean TAC was greater in group I (1.82 ± 0.19). A statistically significant negative correlation as seen between TAC and salivary pH in S-ECC patients. Conclusion The study concludes that salivary TAC increases in patients with S-ECC are by that showing a high indirect relationship with salivary pH. How to cite this article Muchandi S, Walimbe H, Bijle MNA, Nankar M, Chaturvedi S, Karekar P. Comparative Evaluation and Correlation of Salivary Total Antioxidant Capacity and Salivary pH in Caries-free and Severe Early Childhood Caries Children. J Contemp Dent Pract 2015;16(3):234-237.

Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries

2014 ◽  
Vol 49 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Yan Si ◽  
Shuang Ao ◽  
Weijian Wang ◽  
Feng Chen ◽  
Shuguo Zheng
Keyword(s):  
Mass Spectrometry ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Expression Profiles ◽  
Salivary Protein ◽  
Preschool Age ◽  
Diagnostic Model ◽  
Peptide Mass ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Objective: To investigate the differential salivary protein expression profiles between children with severe early childhood caries (S-ECC) and caries-free (CF) children at the age of 3 years. Methods: We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads, and peptide mass fingerprints were created by scanning mass spectrometry signals. Salivary samples from 20 children were analyzed (10 for each group). Results: Eleven protein peaks were significantly different (p < 0.05) between the two groups. Eight of these peaks were higher in the S-ECC group and three were higher in the CF group. To establish a diagnostic model for discrimination between the two groups, we chose three peptides (3,186.2, 3,195.8 and 3,324.8 Da) that exhibited the best fitted curve, by which the two groups were better separated when compared with other combinations. Conclusions: The salivary biomarkers identified revealed significant differences between the CF and the S-ECC group. Our results provide novel insight into the salivary protein profile of preschool-age children with dental caries and may lead to the development of a new strategy for screening high-risk populations.

scholarly journals Dental Treatments under the General Anesthesia in a Child with Keratitis, Ichthyosis, and Deafness Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Sera Sımsek Derelioglu ◽  
Yücel Yılmaz ◽  
Sultan Keles
Keyword(s):  
Early Childhood ◽  
Case Report ◽  
General Anesthesia ◽  
Early Childhood Caries ◽  
Sensorineural Deafness ◽  
Oral Symptoms ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

KID syndrome is a rare genodermatosis characterized by keratitis, ichthyosis, and sensorineural deafness. Although the dermatological, ophthalmologic, and sensorineural defects are emphasized in the literature, oral and dental evaluations are so superficial. In this case report, dental and oral symptoms of a three year and five months old boy with KID syndrome, suffering severe Early Childhood Caries (s-ECC) and dental treatments done under General Anesthesia (GA) were reported.

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