Dental fluorosis and a polymorphism in the COL1A2 gene in Mexican children

2018 ◽  
Vol 96 ◽  
pp. 21-25 ◽  
Author(s):  
Lizet Jarquín-Yñezá ◽  
Jorge Alejandro Alegría-Torres ◽  
Claudia G. Castillo ◽  
José de Jesús Mejía-Saavedra
Keyword(s):  
Dental Fluorosis ◽  
Mexican Children ◽  
Col1a2 Gene

scholarly journals Single Nucleotide Polymorphisms in COL1A2 Gene and Dental Fluorosis Among 4 and 8-Year-Old Nigerian Children

2020 ◽  
pp. 1-6
Author(s):  
Ruth Valentine ◽  
Olushola Ibiyemi ◽  
Anne Maguire ◽  
Fatemeh Vida Zohoori ◽  
Simon Kometa ◽  
...  
Keyword(s):  
Drinking Water ◽  
Single Nucleotide Polymorphisms ◽  
Dental Fluorosis ◽  
Nucleotide Polymorphisms ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Nigerian Children ◽  
Col1a2 Gene ◽  
Cooking Water ◽  
Study Participants

Aim: To determine the association between single nucleotide polymorphisms (SNPs) within the COL1A2 gene and dental fluorosis among 4- and 8-year-old Nigerian children. Methods: A cross-sectional study was undertaken among 125 four and eight-year-old Nigerian children living in naturally fluoridated areas of Ibadan, Nigeria. Drinking and cooking water samples were collected for F analysis. Buccal mucosa swabs were collected from all children and genomic DNA extracted. Presence or absence of the SNP within the COL1A2 gene was identified by PCR and DNA sequencing for 70 of the participants. Results: The median (minimum, maximum) F concentration of drinking and cooking water were 0.05 (<0.1, 3.0) mg/L and 0.01 (<0.1, 4.0) mg/L respectively. The majority of the study participants (52.9%) were heterozygous for the SNP. There was a statistically significant association between F concentration in drinking water and the occurrence of dental fluorosis (p=0.04). F concentration in drinking water was the only statistically significant predictor of dental fluorosis (p=0.03, OR=3.64(CI=1.11-11.94)) after adjusting for F concentration in cooking water and SNPs. The risk of dental fluorosis tended to increase with the presence of SNPs AA and AC (RR > 1) but this association was not statistically significant. Conclusion: The majority of the study participants had the heterozygote SNP AC genotype of COL1A2 gene. F concentration in drinking water was the only statistically significant predictor of dental fluorosis. The risk of dental fluorosis tended to increase with the presence of SNPs AA and AC (RR > 1) but was not statistically significant.

Collagenase 1A2 (COL1A2) gene A/C polymorphism in relation to severity of dental fluorosis

2015 ◽  
Vol 44 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Diana Escobar-García ◽  
Jesús Mejía-Saavedra ◽  
Lizet Jarquín-Yáñez ◽  
Nelly Molina-Frechero ◽  
Amaury Pozos-Guillén
Keyword(s):  
Dental Fluorosis ◽  
Col1a2 Gene

COL1A2 gene polymorphisms (PvuII andRsaI), serum calciotropic hormone levels, and dental fluorosis

2008 ◽  
Vol 36 (6) ◽  
pp. 517-522 ◽  
Author(s):  
Hui Huang ◽  
Yue Ba ◽  
Liuxin Cui ◽  
Xuemin Cheng ◽  
Jingyuan Zhu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Dental Fluorosis ◽  
Hormone Levels ◽  
Col1a2 Gene

Association of COL1A2 gene polymorphism with dental fluorosis in children of Jaipur district of Rajasthan, India

2016 ◽  
Vol 3 (4) ◽  
pp. 249-255 ◽  
Author(s):  
Chetram Meena ◽  
◽  
G.S. Toteja ◽  
Kumud Bala ◽  
S.S. Mohanty ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Dental Fluorosis ◽  
Col1a2 Gene

Diseases Prevention by Water Defluoridation Using Hydrotalcites as Decontaminant Materials

2017 ◽  
Vol 68 (1) ◽  
pp. 168-171 ◽  
Author(s):  
Letitia Doina Duceac ◽  
Cristina Elena Dobre ◽  
Ioana Pavaleanu ◽  
Gabriela Calin ◽  
Simona Nichitus ◽  
...  
Keyword(s):  
Dental Fluorosis ◽  
Precipitation Method ◽  
Original Structure ◽  
Fluoride Removal ◽  
Major Goal ◽  
Bone Stiffness ◽  
Morphological Aspects ◽  
Adsorption Capacities ◽  
Interlayer Structure ◽  
Co Precipitation

Preventing diseases is deemed to be the major goal of our century especially when an excessive fluoride in drinking water can cause dental fluorosis, bone stiffness, rheumatism and skeletal fluorosis. Fluoride uptake from groundwater implies a worldwide multidisciplinary effort in order to develop renewable, cheap, human friendly materials. Among other materials, hydrotalcites could be good candidates for an efficient fluoride removal from water due to their adsorption, anion exchange and reconstruction properties. These nanostructured materials were synthesized using co-precipitation method in controlled conditions. Presence of anions in the interlayer structure and morphological aspects were performed by FTIR and SEM techniques. Thermal treatment of hydrotalcites showed good adsorption capacities for water defluoridation mostly due to their tendency to restore the original structure.

Fluorosis dental en niños de 12 y 15 años del municipio de Andes Dental fluorosis in children

2016 ◽  
Vol 29 (1) ◽  
pp. 33-43
Author(s):  
Blanca Susana Ramírez-Puerta ◽  
◽  
Héctor Manuel Molina-Ochoa ◽  
Jessica Lorena Morales-Flórez ◽  
Keyword(s):  
Dental Fluorosis

scholarly journals Glutamine: Beneficial to prevent oral mucositis in Mexican children with acute lymphoblastic leukemia?

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Miriam R. Caselin-García ◽  
Katja Stein ◽  
Miguel R. Kumazawa-Ichikawa ◽  
Oscar González-Ramella ◽  
Edgar M. Vásquez-Garibay ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Oral Mucositis ◽  
Lymphoblastic Leukemia ◽  
Mexican Children
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