scholarly journals Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

2021 ◽  
Author(s):  
Shilia Jacob Kurian ◽  
Mazhuvancherry Kesavan Unnikrishnan ◽  
Sonal Sekhar Miraj ◽  
Debasis Bagchi ◽  
Mithu Banerjee ◽  
...  
Keyword(s):  
Future Prospects ◽  
Current Perspective ◽  
Prevention And Treatment

scholarly journals Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

2020 ◽  
pp. 1-14 ◽  
Author(s):  
Navya Vyas ◽  
Shilia Jacob Kurian ◽  
Debasis Bagchi ◽  
Mohan K. Manu ◽  
Kavitha Saravu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Future Prospects ◽  
Current Perspective ◽  
Prevention And Treatment

scholarly journals Platinum-Induced Peripheral Neuropathy (PIPN): ROS-Related Mechanism, Therapeutic Agents, and Nanosystems

2021 ◽  
Vol 8 ◽  
Author(s):  
Xi Hu ◽  
Zhijie Jiang ◽  
Longyu Teng ◽  
Hongyu Yang ◽  
Dongsheng Hong ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root ◽  
Therapeutic Agents ◽  
Ros Generation ◽  
Oxygen Species ◽  
Future Prospects ◽  
Cellular Regulation ◽  
Therapeutic Drugs ◽  
Prevention And Treatment ◽  
Huge Challenge

Platinum (Pt) drugs (e.g., oxaliplatin, cisplatin) are applied in the clinic worldwide for the treatment of various cancers. However, platinum-induced peripheral neuropathy (PIPN) caused by the accumulation of Pt in the peripheral nervous system limits the clinical application, whose prevention and treatment are still a huge challenge. To date, Pt-induced reactive oxygen species (ROS) generation has been studied as one of the primary mechanisms of PIPN, whose downregulation would be feasible to relieve PIPN. This review will discuss ROS-related PIPN mechanisms including Pt accumulation in the dorsal root ganglia (DRG), ROS generation, and cellular regulation. Based on them, some antioxidant therapeutic drugs will be summarized in detail to alleviate the Pt-induced ROS overproduction. More importantly, we focus on the cutting-edge nanotechnology in view of ROS-related PIPN mechanisms and will discuss the rational fabrication of tailor-made nanosystems for efficiently preventing and treating PIPN. Last, the future prospects and potential breakthroughs of these anti-ROS agents and nanosystems will be briefly discussed.

scholarly journals The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1211
Author(s):  
Thi Thuy Tien Vo ◽  
Pei-Ming Chu ◽  
Vo Phuoc Tuan ◽  
Joyce Si-Liang Te ◽  
I-Ta Lee
Keyword(s):  
Oxidative Stress ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Inflammatory Disease ◽  
Therapeutic Agents ◽  
Future Prospects ◽  
Pharmacological Activities ◽  
Current Review ◽  
Prevention And Treatment

There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.

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