scholarly journals The Promising Role of Antioxidant Phytochemicals in the Prevention and Treatment of Periodontal Disease via the Inhibition of Oxidative Stress Pathways: Updated Insights

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1211
Author(s):  
Thi Thuy Tien Vo ◽  
Pei-Ming Chu ◽  
Vo Phuoc Tuan ◽  
Joyce Si-Liang Te ◽  
I-Ta Lee
Keyword(s):  
Oxidative Stress ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Inflammatory Disease ◽  
Therapeutic Agents ◽  
Future Prospects ◽  
Pharmacological Activities ◽  
Current Review ◽  
Prevention And Treatment

There is growing evidence on the involvement of oxidative stress, which is simply described as the imbalance between oxidants and antioxidants in favor of the former, in the development of periodontal disease that is the most common inflammatory disease in the oral cavity. Thus, the potential of antioxidant phytochemicals as adjunctively preventive and therapeutic agents against the initiation and progression of periodontal disease is a topic of great interest. The current review firstly aims to provide updated insights about the immuno-inflammatory pathway regulated by oxidative stress in periodontal pathology. Then, this work further presents the systemic knowledge of antioxidant phytochemicals, particularly the pharmacological activities, which can be utilized in the prevention and treatment of periodontal disease. Additionally, the challenges and future prospects regarding such a scope are figured out.

scholarly journals Role of Natural Stilbenes in the Prevention of Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
J. Antoni Sirerol ◽  
María L. Rodríguez ◽  
Salvador Mena ◽  
Miguel A. Asensi ◽  
José M. Estrela ◽  
...  
Keyword(s):  
Mechanisms Of Action ◽  
Pharmacological Activities ◽  
Important Group ◽  
Prevention And Treatment ◽  
Low Toxicity ◽  
Prevention Of Cancer ◽  
Novel Drug ◽  
Improve Stability

Natural stilbenes are an important group of nonflavonoid phytochemicals of polyphenolic structure characterized by the presence of a 1,2-diphenylethylene nucleus. Stilbenes have an extraordinary potential for the prevention and treatment of different diseases, including cancer, due to their antioxidant, cell death activation, and anti-inflammatory properties which associate with low toxicity underin vivoconditions. This review aims to discuss various approaches related to their mechanisms of action, pharmacological activities in animal models and humans, and potential chemoprevention in clinical studies. The biological activity of natural stilbenes is still incompletely understood. Furthermore, after administration to animals or humans, these molecules are rapidly metabolized. Thus pharmacokinetics and/or activities of the natural structures and their metabolites may be very different. Novel drug formulations have been postulated in order to improve stability and bioavailability, to minimize side effects, and to facilitate interaction with their domains in target proteins. These pharmacological improvements should lead stilbenes to become effective candidates as anticancer drugs.

scholarly journals OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS

2016 ◽  
Vol 57 (3) ◽  
pp. 91-99
Author(s):  
N. I. Gorbenko ◽  
O. V. Ivanova ◽  
A. Y. Borikov
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Retrospective Analysis ◽  
Cardiometabolic Risk ◽  
Insulin Resistance Syndrome ◽  
Natural Antioxidants ◽  
Diabetic Macroangiopathy ◽  
Prevention And Treatment ◽  
Main Factors

The review elucidates the role of oxidative stress in the pathogenesis of diabetic cardiovascularcomplications. It was analyzed the main reasons for excessive production of reactive oxygen speciesin the conditions of hyperglycemia and the basic mechanisms of their damaging effect on the morphological and functional state of the myocardium and endothelium. It was considered theperspective of natural antioxidants, such as flavonoids, for the prevention and treatment of diabeticmacroangiopathy. It was made a retrospective analysis of own researches devoted to the quercetin effect on the main factors of cardiometabolic risk at the insulin resistance syndrome

scholarly journals Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 91
Author(s):  
Yuanqiang Ma ◽  
Gyurim Lee ◽  
Su-Young Heo ◽  
Yoon-Seok Roh
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Therapeutic Agents ◽  
Nonalcoholic Fatty Liver ◽  
Stress Oxidative ◽  
The Relationship

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.

scholarly journals Platinum-Induced Peripheral Neuropathy (PIPN): ROS-Related Mechanism, Therapeutic Agents, and Nanosystems

2021 ◽  
Vol 8 ◽  
Author(s):  
Xi Hu ◽  
Zhijie Jiang ◽  
Longyu Teng ◽  
Hongyu Yang ◽  
Dongsheng Hong ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root ◽  
Therapeutic Agents ◽  
Ros Generation ◽  
Oxygen Species ◽  
Future Prospects ◽  
Cellular Regulation ◽  
Therapeutic Drugs ◽  
Prevention And Treatment ◽  
Huge Challenge

Platinum (Pt) drugs (e.g., oxaliplatin, cisplatin) are applied in the clinic worldwide for the treatment of various cancers. However, platinum-induced peripheral neuropathy (PIPN) caused by the accumulation of Pt in the peripheral nervous system limits the clinical application, whose prevention and treatment are still a huge challenge. To date, Pt-induced reactive oxygen species (ROS) generation has been studied as one of the primary mechanisms of PIPN, whose downregulation would be feasible to relieve PIPN. This review will discuss ROS-related PIPN mechanisms including Pt accumulation in the dorsal root ganglia (DRG), ROS generation, and cellular regulation. Based on them, some antioxidant therapeutic drugs will be summarized in detail to alleviate the Pt-induced ROS overproduction. More importantly, we focus on the cutting-edge nanotechnology in view of ROS-related PIPN mechanisms and will discuss the rational fabrication of tailor-made nanosystems for efficiently preventing and treating PIPN. Last, the future prospects and potential breakthroughs of these anti-ROS agents and nanosystems will be briefly discussed.

scholarly journals Role of the Filifactor alocis Hypothetical Protein FA519 in Oxidative Stress Resistance

2021 ◽  
Author(s):  
Ezinne Aja ◽  
Arunima Mishra ◽  
Yuetan Dou ◽  
Hansel M. Fletcher
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Stress Resistance ◽  
Hypothetical Protein ◽  
Content Type ◽  
Genetic Tools ◽  
Oxidative Stress Resistance ◽  
Filifactor Alocis ◽  
Diagnostic Indicator

Filifactor alocis is an emerging member of the periodontal community and is now proposed to be a diagnostic indicator of periodontal disease. However, due to the lack of genetic tools available to study this organism, not much is known about its virulence attributes.

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis

2020 ◽  
Vol 46 (05) ◽  
pp. 553-562
Author(s):  
Joshua Talev ◽  
Jagat Rakesh Kanwar
Keyword(s):  
Iron Oxide ◽  
Cardiovascular Diseases ◽  
Iron Oxide Nanoparticles ◽  
Imaging Techniques ◽  
Therapeutic Agents ◽  
Oxide Nanoparticles ◽  
Future Prospects ◽  
Wide Range ◽  
Theranostic Applications

AbstractAtherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will first discuss current imaging techniques for the diagnosis of atherosclerosis as well as their limitations. It will then discuss the role of nanotechnology for molecular imaging of atherosclerosis and the benefits of this approach as well as reviewing current developments in the field including single, bi-, and tri-modal imaging. Next, it will discuss the role of nanotechnology for therapies of atherosclerosis with a focus on nanotheranostics, concluding with a look at the challenges faced by nanoparticle-based imaging and therapy of atherosclerosis as well as a look at future prospects.

Prevention and management of type II diabetes chronic complications: the role of polyphenols (Mini-Review)

2021 ◽  
Vol 28 ◽  
Author(s):  
Arianna Pani ◽  
Francesco Baratta ◽  
Daniele Pastori ◽  
Mattia Coronati ◽  
Francesco Scaglione ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Damage ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Search Terms ◽  
Prevention And Treatment ◽  
Constant State ◽  
Treatment Of Diabetes ◽  
Ischemic Events

: The numerous complications of diabetes may be at least in part generated by the oxidative stress associated with the constant state of hyperglycemia. Polyphenols are plant based secondary metabolites that have high potentials in the prevention and treatment of some diseases, in particular those that involve oxidative stress, such as complications of diabetes. The purpose of this narrative review is to show the main evidence regarding the role of polyphenols in treating and preventing these complications. For the bibliographic research, the papers published up to March 15, 2021 were considered and the search terms included words relating to polyphenols, their classes and some more known compounds, in association with the complications of diabetes. There are numerous studies showing how polyphenols are active against endothelial damage induced by diabetes, oxidative stress and hyperinflammatory states that are at the origin of the complications of diabetes. Compounds such as flavonoids, but also anthocyanins, stilbenes or lignans slow the progression of kidney damage, prevent ischemic events and diabetic nephropathy. Many of these studies are preclinical, in cellular or animal models. The role of polyphenols in the prevention and treatment of diabetes complications is undoubtedly promising. However, more clinical trials need to be implemented to understand the real effectiveness of these compounds.

scholarly journals An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle-Induced Toxicities

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Vladimir Mihailovic ◽  
Jelena S. Katanic Stankovic ◽  
Dragica Selakovic ◽  
Gvozden Rosic
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Therapeutic Agents ◽  
Protective Mechanisms ◽  
Defense Systems ◽  
Naturally Occurring ◽  
New Findings ◽  
Antioxidant Defense Systems ◽  
Harmful Effects

Nanoparticles (NPs) are used in many products and materials for humans such as electronics, in medicine for drug delivery, as biosensors, in biotechnology, and in agriculture, as ingredients in cosmetics and food supplements. Besides that, NPs may display potentially hazardous properties on human health and the environment as a consequence of their abundant use in life nowadays. Hence, there is increased interest of researchers to provide possible therapeutic agents or dietary supplements for the amelioration of NP-induced toxicity. This review summarizes the new findings in the research of the use of antioxidants as supplements for the prevention and alleviation of harmful effects caused by exposure of organisms to NPs. Also, mechanisms involved in the formation of NP-induced oxidative stress and protective mechanisms using different antioxidant substances have also been elaborated. This review also highlights the potential of naturally occurring antioxidants for the enhancement of the antioxidant defense systems in the prevention and mitigation of organism damage caused by NP-induced oxidative stress. Based on the presented results of the most recent studies, it may be concluded that the role of antioxidants in the prevention and treatment of nanoparticle-induced toxicity is unimpeachable. This is particularly important in terms of oxidative stress suppression.

scholarly journals The Connection of Periodontal Disease and Diabetes Mellitus: The Role of Matrix Metalloproteinases and Oxidative Stress

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Dragana Stanisic ◽  
Radmila Obradovic ◽  
Sanja Vujovic ◽  
Milica Jovanovic ◽  
Vladimir Zivkovic
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Matrix Metalloproteinases ◽  
Periodontal Disease ◽  
Membrane Receptors ◽  
World Health ◽  
Dental Biofilm ◽  
Periodontal Tissues ◽  
And Oxidative Stress

Abstract Diabetes mellitus, a chronic disease considered by the World Health Organization to be an epidemic, is now recognized as one of the factors behind the onset of periodontal disease. The connection between periodontal disease, which is an irreversible inflammatory disease of the supporting tissue of the teeth, and systemic diseases is reflected in the existence of common risk factors, subgingival dental biofilm, as a constant source of proinflamma-tory cytokines synthesized intensely in inflammatory periodontium. Diabetes mellitus leads to increased oxidative stress in periodontal tissues causing worsening of the disease and periodontopathy exacerbates deficiency of pancreatic β-cells. The most important role in primary inflammatory response in the pathogenesis of periodontopathy is played by neutrophils. Neutrophils cause periodontium destruction by the release of enzymes (matrix metalloproteinases), cytotoxic substances (free radicals, reactive oxygen and nitrogen species) and the expression of membrane receptors. Matrix metalloproteinases within the “protease network” are critical to many physiological and pathological processes, including immunity, inflammation, bone resorption and wound healing. Matrix metalloproteinases levels are elevated in patients with metabolic syndrome and diabetes mellitus, which may contribute to more frequent complications. In this paper, the review of available literature data shows the correlation between periodontal disease and diabetes mellitus, as well as the role of matrix metalloproteinases and oxidative stress in these. In this regard, determining the value of matrix metalloproteinases may be helpful in the diagnosis of periodontal disease complicated by diabetes mellitus. Also, the parameters of oxidative stress could help to clarify the mechanisms of pathogenesis and etiology of periodontal disease, or indicate the potential benefit of antioxidant supplementation in these individuals. As the role of matrix metalloproteinases has not been fully clarified in the pathogenesis of periodontopathy, additional studies will be needed to indicate their importance.

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