Juvenile hormone antagonistic activity of secondary metabolites from Streptomyces lactacystinicus and their insecticidal activity against Plutella xylostella

2022 ◽  
pp. 101870
Author(s):  
Jun Young Kim ◽  
Jae Young Choi ◽  
Dong Hwan Park ◽  
Min Gu Park ◽  
Minghui Wang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Juvenile Hormone ◽  
Insecticidal Activity ◽  
Plutella Xylostella ◽  
Antagonistic Activity

Synthesis and insecticidal activity of 6,8-dichloro-quinazoline derivatives containing a sulfide substructure

2014 ◽  
Vol 68 (7) ◽  
Author(s):  
Jian Wu ◽  
Song Bai ◽  
Min Yue ◽  
Li-Jun Luo ◽  
Qin-Cai Shi ◽  
...  
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Insecticidal Activity ◽  
Plutella Xylostella ◽  
Elemental Analyses ◽  
Quinazoline Derivatives ◽  
Sulfide Group

AbstractA series of 6,8-dichloro-quinazoline derivatives bearing a sulfide group was synthesized and characterized via 1H NMR, 13C NMR, IR and elemental analyses. All the compounds were tested for their insecticidal activity against Plutella xylostella in vitro. The results indicate that the synthesized compounds possess good insecticidal activity. Among these compounds, Vc, Vi, Vj, Vk and Vm displayed 75 %, 85 %, 80 %, 70 % and 63 % activities, respectively. These may prove useful as insecticidal agents.

scholarly journals Complete Genome Sequence of Bacillus velezensis L-1, Which Has Antagonistic Activity against Pear Diseases

2017 ◽  
Vol 5 (48) ◽  
Author(s):  
Pingping Sun ◽  
Jianchao Cui ◽  
Xiaohui Jia ◽  
Wenhui Wang
Keyword(s):  
Secondary Metabolites ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Biocontrol Agent ◽  
Antagonistic Activity ◽  
Bacillus Velezensis ◽  
Content Type

ABSTRACT Bacillus velezensis L-1 is an effective biocontrol agent against pear diseases. Here, we report the complete genome sequence of B. velezensis L-1 in which clusters related to the biosynthesis of secondary metabolites were predicted. This genome provides insights into the possible biocontrol mechanisms and furthers application of this specific bacterium.

scholarly journals Design, Synthesis, and Evaluation of X-ray Crystal Structure, Biological Activities, DFT Calculations, and Molecular Docking of Phenyl Imidazolidin-2-One Derivatives

Crystals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 713
Author(s):  
Xile Deng ◽  
Can Jin ◽  
Yong Xie ◽  
Junbo Gao ◽  
Xiaomao Zhou
Keyword(s):  
Molecular Docking ◽  
Dft Calculations ◽  
Insecticidal Activity ◽  
Plutella Xylostella ◽  
Density Functional ◽  
Biological Activities ◽  
Phytophthora Sojae ◽  
Ring Closure ◽  
Binding Modes ◽  
X Ray

Eight phenyl imidazolinone derivatives were synthesized from N2-(2,4-dimethylphenyl)-N1-methyformamidine (DPMF) via scaffold-hopping method using the ring-closure approach. The prepared compounds were verified using 1H and 13C NMR and HRMS spectroscopies. The structure of compound 3c was confirmed by single-crystal X-ray diffraction analysis. The mean plane of the phenyl and imidazolinone moieties was almost coplanar with an angle of 8.85(4)°. In the crystal, molecules were interlinked with intermolecular hydrogen bonds (N–H···O and C–H···O), generating a network structure. Additionally, compound 3f displayed the highest insecticidal activity (86.7%) against Plutella xylostella at 600 mg/L, which was significantly higher than the insecticidal activity (23.0%) of DPMF. Also, compound 3d displayed good fungicidal activities against Phytophthora capsici, Phytophthora sojae, and Phytophthora infestans. Density functional theory (DFT) calculations were performed to explain the insecticidal and fungicidal activities of phenyl imidazolidin-2-one derivatives, especially potent compounds 3f and 3d. Moreover, the binding modes of compounds 3a–h and DPMF against octopamine receptor of Plutella xylostella were studied by homology modeling and molecular docking. Therefore, a preliminary structure–activity relationship (SAR) was derived and discussed. These results encourage the exploration of novel insecticides and fungicides based on DPMF.

Antifeedant Activities of Secondary Metabolites from Hyssopus cuspidatus Against Plutella xylostella

2018 ◽  
Vol 54 (6) ◽  
pp. 1088-1090
Author(s):  
Hai-bo Wu ◽  
Ting-ting Liu ◽  
Yu-xuan Lian ◽  
Xue Chen ◽  
Wen-shu Wang
Keyword(s):  
Secondary Metabolites ◽  
Plutella Xylostella

Tetrafluorobenzyl Alcohol-Oriented Novel (S)-Enantiomeric Esters: Synthesis and Structure-Activity Relationship

2019 ◽  
Vol 15 (1) ◽  
pp. 98-102
Author(s):  
Wenda Wang ◽  
Haihuan Su ◽  
Huangyong Li ◽  
Xiufang Cao
Keyword(s):  
Asymmetric Synthesis ◽  
Insect Resistance ◽  
Insecticidal Activity ◽  
Plutella Xylostella ◽  
The Novel ◽  
Lead Compound ◽  
Tolerance Development ◽  
Structure Activity ◽  
Stereoselective Method ◽  
Insecticidal Activities

Background: Using constantly and widely chemistry insecticides has resulted in a selection burden and favored tolerance development in various insect species. Particularly, pyrethroids are the only one which can be used for net impregnation either ITNs or LLIN as yet, however, the excessive use of pyrethroids has led to many cases of insect resistance in worldwide. Therefore, it is urgent to develop novel insecticides fighting against this sort of resistance. Methods: Based on the preliminary studies, we explored a straightforward highly stereoselective method to achieve the novel chiral ester derivatives by using Oppolzer’s 10,2-camphorsultam as chiral controlling reagent. Results: A series of tetrafluorobenzyl alcohol oriented (S)-enantiomeric esters were designed and synthesized by the asymmetric synthesis. All the compounds exhibited moderate yields, and the original synthesized compounds have been evaluated for their potential insecticidal activity against Plutella xylostella compared with those of fenvalerate and D-trans-phenothrin, and some compounds presented excellent insecticidal activities. Conclusion: The bioassay illustrated that some of the compounds exhibit obviously insecticidal activities against Plutella xylostella, especially, the insecticidal activity of compound 5i was as good as commercial fenvalerate and D-trans-phenothrin, which can be used as a lead compound for further optimization.

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