Serum opacity factor normalizes dysfunctional HDL phenotype in SRB1 -/- mice

2021 ◽  
Vol 331 ◽  
pp. e124
Author(s):  
D. Yelamanchili ◽  
B.K. Gillard ◽  
A.M. Gotto ◽  
H.J. Pownall ◽  
C. Rosales
Keyword(s):  
Serum Opacity Factor ◽  
Dysfunctional Hdl

scholarly journals Dysfunctional HDL and progression of atherosclerosis in HIV-1-infected and -uninfected adults

2013 ◽  
Vol 12 (1) ◽  
pp. 23 ◽  
Author(s):  
Theodoros Kelesidis ◽  
Otto O Yang ◽  
Michelle A Kendall ◽  
Howard N Hodis ◽  
Judith S Currier
Keyword(s):  
Dysfunctional Hdl ◽  
Hiv 1 ◽  
Progression Of Atherosclerosis

scholarly journals Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

2020 ◽  
Author(s):  
Yujiro Hirose ◽  
Masaya Yamaguchi ◽  
Norihiko Takemoto ◽  
Tohru Miyoshi-Akiyama ◽  
Tomoko Sumitomo ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Genetic Characterization ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Gene Encoding ◽  
Serum Opacity Factor ◽  
Genetic Features ◽  
Fibronectin Binding Protein

Streptococcal toxic shock syndrome (STSS) caused by Streptococcus pyogenes emm 89 strains has been increasing in several countries and reported to be linked with a recently emerged clade of emm89 strains, designated clade 3. In Japan, epidemiological and genetic information for emm89 strains remains elusive. In this study, we utilized emm89 strains isolated from both STSS (89 isolates) and non-STSS (72 isolates) infections in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, STSS-associated genes and SNPs were found in clade 3 strains, including mutations of streptokinase (Ska), control of virulence sensor (CovS), serum opacity factor (SOF), sortase (SrtB), and fibronectin-binding protein F1 (PrtF1), and absence of the hylP1 gene encoding hyaluronidase. These findings provide insights into notable genetic features of emm89 strains.

scholarly journals High-Density Lipoprotein (HDL) Triglyceride and Oxidized HDL: New Lipid Biomarkers of Lipoprotein-Related Atherosclerotic Cardiovascular Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 362 ◽  
Author(s):  
Fumiaki Ito ◽  
Tomoyuki Ito
Keyword(s):  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Peroxide ◽  
Hdl Cholesterol ◽  
High Density ◽  
Atherosclerotic Cardiovascular Disease ◽  
Lipid Panel ◽  
Lipid Markers ◽  
Dysfunctional Hdl

Lipid markers are well-established predictors of vascular disease. The most frequently measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglyceride. HDL reduces atherosclerosis by multiple mechanisms, leading to a reduced risk of cardiovascular disease, and HDL-C, as a metric of HDL quantity, is inversely associated with cardiovascular disease, independent of LDL-C. However, the quality of the HDL appears to be more important than its quantity, because HDL loses its antiatherogenic functions due to changes in its composition and becomes “dysfunctional HDL”. Although there is evidence of the existence of “dysfunctional HDL”, biomarkers for monitoring dysfunctional HDL in clinical practice have not yet been established. In this review, we propose a new lipid panel for the assessment of dysfunctional HDL and lipoprotein-related atherosclerotic cardiovascular disease. The lipid panel includes the measurement of lipid peroxide and triglyceride contents within HDL particles.

scholarly journals Dysfunctional HDL and atherosclerotic cardiovascular disease

2015 ◽  
Vol 13 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Robert S. Rosenson ◽  
H. Bryan Brewer ◽  
Benjamin J. Ansell ◽  
Philip Barter ◽  
M. John Chapman ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Dysfunctional Hdl

Mapping the Fibrinogen-Binding Domain of Serum Opacity Factor of Group A Streptococci

2002 ◽  
Vol 44 (4) ◽  
pp. 236-240 ◽  
Author(s):  
Harry S. Courtney ◽  
James B. Dale ◽  
David L. Hasty
Keyword(s):  
Binding Domain ◽  
Group A Streptococci ◽  
Fibrinogen Binding ◽  
Serum Opacity Factor ◽  
Group A
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