Non-alcoholic fatty liver disease and subclinical atherosclerosis in a population affected by familial hypercholesterolemia

2021 ◽  
Vol 331 ◽  
pp. e202-e203
Author(s):  
A. Mondelli ◽  
A. Redheuil ◽  
P. Giral ◽  
V. Carreau ◽  
R. Pais ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Familial Hypercholesterolemia ◽  
Fatty Liver Disease ◽  
Subclinical Atherosclerosis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Association of anti-oxidative capacity of HDL with subclinical atherosclerosis in subjects with and without non-alcoholic fatty liver disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sara Karami ◽  
Hossein Poustchi ◽  
Negar Sarmadi ◽  
Amir Reza Radmard ◽  
Fatemeh Ali Yari ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Subclinical Atherosclerosis ◽  
Oxidative Capacity ◽  
Paraoxonase 1 ◽  
Sod Activity ◽  
Alcoholic Fatty Liver ◽  
Oxidative Function ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) patients are at a substantial risk for developing cardiovascular disease (CVD). High-density lipoprotein (HDL) is well known to have protective effects against the development of atherosclerotic CVD. One of the major antiatherogenic effects of HDL is its anti-oxidative function. Objectives This study investigated the association of anti-oxidative capacity of HDL with subclinical atherosclerosis in NAFLD and non-NAFLD subjects. Methods A total of 143 subjects including 51 NAFLD and 92 control subjects were included in this case–control study. HDL oxidative index (HOI) was determined spectrophotometrically using a cell-free method in the presence of a fluorescent substrate dichlorofluorescein diacetate (DCFDA). Paraoxonase 1 (PON1) activity, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) plasma levels were assessed in both groups. Results The NAFLD patients with impaired HDL anti-oxidative function (HOI  ≥ 1) had higher MDA levels, aspartate amino transferase (AST), liver stiffness (LS), and carotid intima-media thickness (cIMT) values compared to the controls. HDL oxidative index (HOI) was positively correlated with MDA levels and cIMT and negatively correlated with SOD activity. Conclusions Higher circulating levels of MDA were associated with the impaired anti-oxidative function of HDL in NAFLD. The impaired anti-oxidative capacity of HDL might be related to NAFLD severity and subclinical atherosclerosis in NAFLD patients.

scholarly journals Association between non-alcoholic fatty liver disease and subclinical atherosclerosis in Western and Asian cohorts: an updated meta-analysis

Open Heart ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. e001850
Author(s):  
Mark Yu Zheng Wong ◽  
Jonathan Jiunn Liang Yap ◽  
Rehena Sultana ◽  
Mark Cheah ◽  
George Boon Bee Goh ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Regional Differences ◽  
Meta Analysis ◽  
Subclinical Atherosclerosis ◽  
Significant Positive Association ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

BackgroundNon-alcoholic fatty liver disease (NAFLD) is a well-established risk factor for cardiovascular disease, with ethnic and regional differences noted. With the recent surge of research within this field, we re-examine the evidence associating NAFLD with subclinical atherosclerosis, and investigate potential regional differences.MethodsThis is a systematic review and meta-analysis. PubMed and EMBASE were systematically searched for publications from January 1967 to July 2020 using standardised criteria. Original, observational studies investigating the association between NAFLD and either carotid intima-media thickness (CIMT) and/or coronary artery calcification (CAC) were included. Key outcomes included differences in mean CIMT, the presence of increased CIMT, the presence of CAC and the development/progression of CAC. Pooled ORs and pooled standard differences in means were calculated using random-effects models. Between-study heterogeneity was quantified using the Q statistic and I². Subgroup analyses stratified by region of study (Asian vs Western) were also conducted.Results64 studies involving a total of 172 385 participants (67 404 with NAFLD) were included. 44 studies assessed the effect of NAFLD on CIMT, with the presence of NAFLD associated with increased CIMT (OR 2.00, 95% CI 1.56 to 2.56). 22 studies assessed the effects of NAFLD on CAC score, with the presence of NAFLD associated with the presence of any coronary calcification (OR 1.21, 95% CI 1.12 to 1.32), and the development/progression of CAC (OR 1.26, 95% CI 1.04 to 1.52). When stratified by region, these associations remained consistent across both Asian and Western populations (p>0.05). The majority (n=39) of studies were classified as ‘high quality’, with the remaining 25 of ‘moderate quality’.ConclusionsThere is a significant positive association between various measures of subclinical atherosclerosis and NAFLD, seen across both Western and Asian populations. These results re-emphasise the importance of early risk evaluation and prophylactic intervention measures to preclude progression to clinical cardiovascular disease in patients with NAFLD.

scholarly journals Association of Anti-oxidative Capacity of HDL With Subclinical Atherosclerosis in Non-alcoholic Fatty Liver Disease

2021 ◽  
Author(s):  
Sara Karami ◽  
Hossein Poustchi ◽  
Negar Sarmadi ◽  
Amir Reza Radmard ◽  
Fatemeh Ali Yari ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Subclinical Atherosclerosis ◽  
Oxidative Capacity ◽  
Paraoxonase 1 ◽  
Sod Activity ◽  
Alcoholic Fatty Liver ◽  
Oxidative Function ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) patients are at the substantial risk for the for developing cardiovascular disease (CVD). High-density lipoprotein (HDL) is well known to have protective effects against the development of atherosclerotic CVD. One of the major antiatherogenic effect of HDL is its anti-oxidative function. Objectives: This study investigated the association of anti-oxidative function of HDL with NAFLD and CVD risk.Methods: A total of 143 subjects including 51 NAFLD and 92 control subjects were included in this cross-sectional study. HDL oxidative index (HOI) was determined spectrophotometrically using a cell-free method in the presence of a fluorescent substrate dichlorofluorescein diacetate (DCFDA). Paraoxonase 1 (PON1) activity, superoxide dismutase (SOD) activity and malondialdehyde (MDA) plasma levels were assessed in both groups.Results: The subjects with impaired HDL anti-oxidative function (HOI≥1) had lower PON1 paraoxonase activity, lower SOD activity, higher MDA levels and higher carotid intima-media thickness (cIMT) values compared to the controls. HDL oxidative index (HOI) was positively correlated with MDA levels and cIMT and negatively correlated with SOD activity. NAFLD patients with HOI≥1 had elevated serum levels of liver enzymes and higher LS values.Conclusions: Alteration in circulating oxidative stress markers may diminish the anti-oxidative function of HDL. Impaired anti-oxidative capacity of HDL might be related to NAFLD severity and subclinical atherosclerosis in NAFLD patients.

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