Serum uric acid and left ventricular geometry pattern in obese children

Abstract Background: Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children. Patients and methods : In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG / HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-hour ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses with stepwise selection were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex. Results : Our study included 70 children (65.71% boys and 34.29% girls) with median age (14 years, IQR=12-16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24h-average SBP with LVMI (effect=3.65, SE=1.32, p<0.01; effect=34.90, SE=6.84, p<0.01; effect=0.32, SE=0.12, p<0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect=13.07, SE=5.02, p=0.01 Insulin: effect=2.80, SE=0.97). Conclusion: Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

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Relation between QT Variables and Left Ventricular Geometry in Athletes and Obese Children

Acta Médica Portuguesa ◽

10.20344/amp.6538 ◽

2016 ◽

Vol 29 (2) ◽

pp. 95 ◽

Cited By ~ 5

Author(s):

Şule Yıldırım ◽

Fatih Köksal Binnetoğlu ◽

Fatih Battal ◽

Hakan Aylanç ◽

Nazan Kaymaz ◽

...

Keyword(s):

Qt Dispersion ◽

Posterior Wall ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Control Group ◽

Obese Children ◽

Basketball Players ◽

Ventricular Geometry ◽

Eccentric Hypertrophy ◽

Obese Subjects

Introduction: We aimed to evaluate the relation between QT variables and left ventricular geometry in athletes and obese children. Material and Methods: This study included 209 children and adolescents. Thirty-eight of them were obese, 140 were athletes and 31 were normal weighted. Children with history of functional and structural cardiovascular diseases (acquired and congenital), chronic systemic diseases, hypertension, sleep apnea, endocrinological disorders were excluded. All subjects underwent detailed electrocardiographic and echocardiographic examination. Results: QT dispersion was significantly higher in obese children, basketball players, football players and swimmers compared to control group (p < 0.05, p < 0.001, < 0.001 and < 0.01 respectively). Basketball players had the highest QT dispersion. Left ventricular endsystolic diameter (mm/m2) was higher in footballers, swimmers, wrestlers and tennis players compared to obese subjects. Interventricular septal thickness at diastole was highest in swimmers compared to control group (p < 0.001) and left ventricular posterior wall thickness was significantly higher in footballers and swimmers compared to healthy subjects (p < 0.01 and p < 0.001 respectively). Left ventricular geometry was normal in 84 patients (47.1%), but 34 patients (19.1%) had concentric remodelling, 20 (22.4%) had concentric hypertrophy and 40 (28.6%) had eccentric hypertrophy. No concentric and eccentric hypertrophy was observed in obese subjects. Left ventricle hypertrophy was prominent in dynamic and combined groups but it was not statistically significant (p = 0.204). QT dispersion was statistically higher in obese, dynamic sports and combined sports compared to control group (p < 0.05, p < 0.001 and p < 0.001 respectively). Discussion: In this study we determined that QT dispersion is elevated in dynamic and combined sports types and obese children. Conclusion: QT dispersion is prolonged in obese and athletes who participate dynamic and combined sports.

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Lipid profile and left ventricular geometry pattern in obese children

Lipids in Health and Disease ◽

10.1186/s12944-020-01285-9 ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Bojko Bjelakovic ◽

Claudia Stefanutti ◽

Vladimir Vukovic ◽

Nebojsa Kavaric ◽

Ljiljana Saranac ◽

...

Keyword(s):

Lipid Profile ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Obese Children ◽

Ventricular Geometry

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Lipid profile and left ventricular geometry pattern in obese children

10.21203/rs.2.23517/v2 ◽

2020 ◽

Author(s):

Bojko Bjelakovic ◽

Claudia Stefanutti ◽

Vladimir Vukovic ◽

Nebojsa Kavaric ◽

Ljiljana Saranac ◽

...

Keyword(s):

Left Ventricular Hypertrophy ◽

Serum Lipid ◽

Ventricular Hypertrophy ◽

Density Lipoprotein ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Obese Children ◽

Ventricular Geometry ◽

The Relationship ◽

Age And Sex

Abstract Background: Left ventricular hypertrophy (LVH) is an important risk factor for cardiovascular and all-cause mortality. Previous studies reported conflicting results concerning the relationship between serum lipid levels and left ventricular geometry pattern. We sought to explore the relationship between standard serum lipid profile measures with left ventricular geometry pattern in obese children.Patients and methods: In this cross-sectional study, a total of 70 obese children were examined. Fasting blood samples were taken to measure total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TGs), glucose, and insulin. Based on these values TG/HDL ratio, BMI and HOMA index were calculated. We also measured the average 24-hour ambulatory systolic blood pressure (SBP) and two-dimensional (2/D) transthoracic echocardiography was performed to determine left ventricular mass index (LVMI) and relative wall thickness (RWT). Multiple regression analyses were conducted to explore relationships between study variables and the LVMI or RWT as outcome variables. The final model with LVMI included TG/HDL ratio, BMI, 24h-average SBP, age and sex, while for the RWT we included BMI, insulin, age and sex.Results: Our study included 70 children (65.71% boys and 34.29% girls) median age (14 years, IQR=12-16)." We demonstrated independent and positive association of TG/HDL ratio, BMI and 24h-average SBP with LVMI (effect=3.65, SE=1.32, p<0.01; effect=34.90, SE=6.84, p<0.01; effect=0.32, SE=0.12, p<0.01, respectively). On the other hand, in model with RWT as outcome variable, only BMI and insulin were significantly linked (BMI: effect=13.07, SE=5.02, p=0.01 Insulin: effect=2.80, SE=0.97).Conclusion: Increased TG/HDL ratio in obese children is associated with the development of eccentric left ventricular hypertrophy while increased BMI and insulin were associated with concentric left ventricular hypertophy.

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