BODY MASS INDEX AND BLOOD PRESSURE IN CHILDREN: NOVEL ELECTROCARDIOGRAPHIC VALUES THAT CORRELATE WITH ECHOCARDIOGRAPHIC LEFT VENTRICULAR GEOMETRY AND MASS IN OBESE CHILDREN

AbstractSalusins have emerged as a new biomarker that reflects an increased inflammatory state, which is associated with cardiovascular risk. We investigated the predictive value and usefulness of salusins as an inflammatory biomarker in obese children. This prospective cohort study included 75 obese children and 101 healthy children (as a control group). Salusin-α, Salusin-β, and various cardiovascular parameters were assessed in both groups. Correlation analyses of Salusin-α and Salusin-β with body mass index standard deviation scores and inflammatory and cardiovascular markers were performed. The mean patient age was 11.9±2.4 years for the obese group and 12.5±2.1 years for the control group. The obese children had a significantly higher heart rate, systolic blood pressure, diastolic blood pressure, epicardial adipose tissue thickness, and left ventricular mass than did the children in the control group. There was no significant correlation between Salusin-α and Salusin-β and body mass index; however, there was a negative correlation between Salusin- α and diastolic blood pressure (r = 0.277, p = 0.004). Overall, there was no significant difference in the Salusin-α and Salusin-β levels between obese and healthy children. However, a negative correlation was found between Salusin-α and diastolic blood pressure. Although this result suggests that Salusin-α might be an early marker of cardiovascular involvement in obese children, further studies are needed to demonstrate the predictive value of salusins.

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E33 Ambulatory blood pressure and left ventricular geometry in older adults

American Journal of Hypertension ◽

10.1016/s0895-7061(97)88820-6 ◽

1997 ◽

Vol 10 (4) ◽

pp. 51A

Author(s):

P RICHEY

Keyword(s):

Blood Pressure ◽

Older Adults ◽

Ambulatory Blood Pressure ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Ventricular Geometry

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Subclinical left ventricular disfunction in obese children: are we late?

10.1101/2020.10.10.20195743 ◽

2020 ◽

Author(s):

B Riaño-Mendez ◽

M Ruiz del Campo ◽

P Garcia-Navas ◽

CM Amiama-Perez de Villarreal ◽

MY Ruiz del Prado

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Mass ◽

Systolic Function ◽

Left Ventricular ◽

Function Evaluation ◽

Obese Children ◽

Global Strain ◽

Cardiovascular Evaluation ◽

Control Study

ABSTRACTAimLongitudinal global strain (LGS) is reduced in obese patients with normal ejection fraction of the left ventricle. TAPSE/PAPS ratio, recently described, may be a step forward a more efficient RV function evaluation.There are still few publications in the application of these methods in pediatric patients.MethodsThis case-control study compared 104 children aged 5-18 years between October 2017 and February 2019, 52 obese children with body mass index (BMI) > +2 SD, and 52 matched controls.They were screened for other cardiovascular risk factors like insulin resistance or hypercholesterolemia. A complete echocardiography including standard and functional parameters was performed.ResultsWe found that obese children presented poor systolic function (LGS −15,90 ± 3,84 %) in comparison with non-obese children (−19,44 ± 5,75 %, p=0,001). LGS correlated positively with body mass index (BMI).Standard echocardiography also revealed cardiomegaly and hypertrophy.TAPSE/PASP ratio correlated negatively with triglycerides levels (β −0,402, p=0,014). Diastolic function was poor in those with HOMA-IR (β −0,375, p=0,016) and hypertriglyceridemia (β −0,375 p=0,024).ConclusionWe think that is necessary to perform a standarised cardiovascular evaluation in obese children for early identification of subclinical dysfunction especially in those with insulin resistance and dyslipidemia

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Abstract P092: Longitudinal Impact Of Blood Pressure On Left Ventricular Geometry In The Hispanic Community Health Study/Study Of Latinos: Echocardiographic Study Of Latinos (Echo-SOL) Ancillary Study

Circulation ◽

10.1161/circ.143.suppl_1.p092 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Jennifer McLeod ◽

Barry E Hurwitz ◽

Daniela Sotres-Alvarez ◽

Mayank M Kansal ◽

Katrina Swett ◽

...

Keyword(s):

Blood Pressure ◽

Left Ventricular ◽

Health Study ◽

Left Ventricular Geometry ◽

Longitudinal Impact ◽

Ventricular Geometry ◽

Concentric Hypertrophy ◽

Echocardiographic Study ◽

Eccentric Hypertrophy ◽

Latino Adults

Introduction: Abnormal left ventricular geometry (LVG) is an independent predictor of cardiovascular mortality. We assessed the longitudinal transitions of LVG among Hispanic/Latino adults. Methods: Echo-SOL provided serial 2D echocardiograms of Hispanic adults. Each subject was identified as hypertensive or normotensive and categorized into four LVG patterns: normal, concentric remodeling (CR), concentric hypertrophy (CH), or eccentric hypertrophy (EH). Hypertensive adults were stratified on whether they maintained blood pressure (BP) control (<140/90mmHg) by visit 2. The normotensive adults were stratified on whether they developed incident hypertension (HTN) by visit 2. Logistic regression was used to evaluate the outcome of normal vs. abnormal LVG at visit 2 adjusting for age, sex, and follow-up time. Results: There were 1818 adults at visit 1 (mean age 56 years; 42.6% male, 44.7% hypertensive), with 1643 obtaining serial echocardiograms an average of 4.3 years later. At visit 1, LVG was distributed as follows: normal, 65.3%; CR, 30.6%, CH 3.1%, and EH 1.1%. Among hypertensive adults at visit 1, 59.7% had normal LVG and 34.1% had CR. By visit 2, there was a progression from normal LVG to CR among those with and without BP control; CR prevalence increased to 58.5% and 55.2%, respectively (Fig. 1). For visit 1 hypertensive adults, the incidence of abnormal LVG did not differ with regards to BP control (adjusted OR 1.1, 95% CI: 0.7-1.7). Among normotensive adults at visit 1, 69.8% had normal LVG. If they remained normotensive by visit 2, this prevalence decreased to 52.2%. If they developed HTN, there was an associated progression toward abnormal geometry (adjusted OR 2.5, 95% CI: 1.4-4.2), with the majority (59.2%) demonstrating a CR phenotype. Conclusion: Our findings suggest that BP control to 140mmHg is not adequate to prevent progressive LV remodeling among Hispanic/Latino adults. Further study is needed to understand this maladaptive process and how it contributes to cardiovascular disease in this population.

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Factors affecting left ventricular remodelling and mechanics in the long-term follow-up after successful repair of aortic coarctation

Cardiology in the Young ◽

10.1017/s104795110500034x ◽

2005 ◽

Vol 15 (2) ◽

pp. 160-167 ◽

Cited By ~ 12

Author(s):

Roberto Crepaz ◽

Roberto Cemin ◽

Cristina Romeo ◽

Edoardo Bonsante ◽

Lino Gentili ◽

...

Keyword(s):

Blood Pressure ◽

Aortic Coarctation ◽

Surgical Repair ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling ◽

Ventricular Geometry ◽

Blood Pressures ◽

Successful Repair

Aims: To identify factors predisposing to abnormal left ventricular geometry and mechanics in 52 patients after successful repair of aortic coarctation. Methods and results: We evaluated left ventricular remodelling, systolic midwall mechanics, and isthmic gradient by echo-Doppler, systemic blood pressure at rest/exercise and by ambulatory blood pressure monitoring, and the aortic arch by magnetic resonance imaging. Echocardiographic findings were compared with those of 142 controls. The patients with aortic coarctation showed an increased indexed left ventricular end-diastolic volume, increased mass index, increased ratio of mass to volume and systolic chamber function. The contractility, estimated at midwall level, was increased in 21 percent of the patients. In 26 (50 percent) of the patients, we found abnormal left ventricular geometry, with 9 percent showing concentric remodelling, 33 percent eccentric hypertrophy, and 8 percent concentric hypertrophy. These patients were found to be older, underwent a later surgical repair, and to have higher systolic blood pressures at rest and exercise as well as during ambulatory monitoring. The relative mural thickness and mass index of the left ventricle showed a significant correlation with different variables on uni- and multivariate analysis. Age and diastolic blood pressure at rest are the only factors associated with abnormal left ventricular remodelling. Conclusions: Patients who have undergone a seemingly successful surgical repair of aortic coarctation may have persistently abnormal geometry with a hyperdynamic state of the left ventricle. This is more frequent in older patients, and in those with higher diastolic blood pressures.

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