P1.8 Low-frequency electro-acupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

2009 ◽  
Vol 149 (1-2) ◽  
pp. 62
Author(s):  
E. Stener-Victorin ◽  
E. Jedel ◽  
P.O. Janson ◽  
Y.B. Sverrisdottir
Keyword(s):  
Physical Exercise ◽  
Polycystic Ovary Syndrome ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Muscle Sympathetic Nerve Activity ◽  
Low Frequency ◽  
Ovary Syndrome ◽  
Nerve Activity

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

2009 ◽  
Vol 297 (2) ◽  
pp. R387-R395 ◽  
Author(s):  
Elisabet Stener-Victorin ◽  
Elizabeth Jedel ◽  
Per Olof Janson ◽  
Yrsa Bergmann Sverrisdottir
Keyword(s):  
Physical Exercise ◽  
Sympathetic Nerve ◽  
Untreated Control ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Muscle Sympathetic Nerve Activity ◽  
Low Frequency ◽  
Control Group ◽  
Burst Frequency ◽  
Nerve Activity

We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA ( n = 9), physical exercise ( n = 5), or untreated control ( n = 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA ( P = 0.036) and physical exercise ( P = 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter ( P = 0.001), while the physical exercise group reduced body weight ( P = 0.004) and body mass index ( P = 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency ( Rs = 0.58, P < 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS.

P1.7 Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

2009 ◽  
Vol 149 (1-2) ◽  
pp. 62
Author(s):  
Y.B. Sverrisdottir ◽  
T. Mogren ◽  
J. Kataoka ◽  
P.O. Janson ◽  
E. Stener-Victorin
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Size At Birth

Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

2008 ◽  
Vol 294 (3) ◽  
pp. E576-E581 ◽  
Author(s):  
Yrsa Bergmann Sverrisdóttir ◽  
Tove Mogren ◽  
Josefin Kataoka ◽  
Per Olof Janson ◽  
Elisabet Stener-Victorin
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Study Groups ◽  
Reproductive Age ◽  
Burst Frequency ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Size At Birth

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disturbance among women of reproductive age and is proposed to be linked with size at birth and increased prevalence of cardiovascular disease. A disturbance in the sympathetic nervous system may contribute to the etiology of PCOS. This study evaluates sympathetic outflow in PCOS and its relation to size at birth. Directly recorded sympathetic nerve activity to the muscle vascular bed (MSNA) was obtained in 20 women with PCOS and in 18 matched controls. Ovarian ultrasonographic evaluation, biometric, hormonal, and biochemical parameters were measured, and birth data were collected. Women with PCOS had increased MSNA (30 ± 8 vs. 20 ± 7 burst frequency, P < 0.0005) compared with controls. MSNA was positively related to testosterone ( r = 0.63, P < 0.005) and cholesterol ( r = 0.55, P = 0.01) levels in PCOS, which, in turn, were not related to each other. Testosterone level was a stronger predictor of MSNA than cholesterol. Birth size did not differ between the study groups. This is the first study to directly address sympathetic nerve activity in women with PCOS and shows that PCOS is associated with high MSNA. Testosterone and cholesterol levels are identified as independent predictors of MSNA in PCOS, although testosterone has a stronger impact. The increased MSNA in PCOS may contribute to the increased cardiovascular risk and etiology of the condition. In this study, PCOS was not related to size at birth.

Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome

2011 ◽  
Vol 36 (10) ◽  
pp. 1470-1479 ◽  
Author(s):  
Elizabeth Jedel ◽  
Deborah Gustafson ◽  
Margda Waern ◽  
Yrsa Bergmann Sverrisdottir ◽  
Mikael Landén ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Sex Steroids ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Affective Symptoms

Relation between QT interval variability and muscle sympathetic nerve activity in normal subjects

2015 ◽  
Vol 309 (7) ◽  
pp. H1218-H1224 ◽  
Author(s):  
Fatima El-Hamad ◽  
Elisabeth Lambert ◽  
Derek Abbott ◽  
Mathias Baumert
Keyword(s):  
Supine Position ◽  
Sympathetic Nerve ◽  
Qt Interval ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Low Frequency ◽  
Normal Subjects ◽  
Nerve Activity ◽  
Head Up Tilt ◽  
Low Frequency Power

Beat-to-beat variability of the QT interval (QTV) is sought to provide an indirect noninvasive measure of sympathetic nerve activity, but a formal quantification of this relationship has not been provided. In this study we used power contribution analysis to study the relationship between QTV and muscle sympathetic nerve activity (MSNA). ECG and MSNA were recorded in 10 healthy subjects in the supine position and after 40° head-up tilt. Power spectrum analysis was performed using a linear autoregressive model with two external inputs: heart period (RR interval) variability (RRV) and MSNA. Total and low-frequency power of QTV was decomposed into contributions by RRV, MSNA, and sources independent of RRV and MSNA. Results show that the percentage of MSNA power contribution to QT is very small and does not change with tilt. RRV power contribution to QT power is notable and decreases with tilt, while the greatest percentage of QTV is independent of RRV and MSNA in the supine position and after 40° head-up tilt. In conclusion, beat-to-beat QTV in normal subjects does not appear to be significantly affected by the rhythmic modulations in MSNA following low to moderate orthostatic stimulation. Therefore, MSNA oscillations may not represent a useful surrogate for cardiac sympathetic nerve activity at moderate levels of activation, or, alternatively, sympathetic influences on QTV are complex and not quantifiable with linear shift-invariant autoregressive models.

Importance of ventilation in modulating interaction between sympathetic drive and cardiovascular variability

2001 ◽  
Vol 280 (2) ◽  
pp. H722-H729 ◽  
Author(s):  
Philippe Van De Borne ◽  
Nicola Montano ◽  
Krzysztof Narkiewicz ◽  
Jean P. Degaute ◽  
Alberto Malliani ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Minute Ventilation ◽  
Low Frequency ◽  
Nerve Activity ◽  
Cardiovascular Variability ◽  
Controlled Breathing ◽  
End Tidal ◽  
Cardiovascular Rhythms

Chemoreflex stimulation elicits both hyperventilation and sympathetic activation, each of which may have different influences on oscillatory characteristics of cardiovascular variability. We examined the influence of hyperventilation on the interactions between changes in R-R interval (RR) and muscle sympathetic nerve activity (MSNA) and changes in neurocirculatory variability, in 14 healthy subjects. We performed spectral analysis of RR and MSNA variability during each of the following interventions: 1) controlled breathing, 2) maximal end-expiratory apnea, 3) isocapnic voluntary hyperventilation, and 4) hypercapnia-induced hyperventilation. MSNA increased from 100% during controlled breathing to 170 ± 25% during apnea ( P = 0.02). RR was unchanged, but normalized low-frequency (LF) variability of both RR and MSNA increased markedly ( P < 0.001). During isocapnic hyperventilation, minute ventilation increased to 20.2 ± 1.4 l/min ( P < 0.0001). During hypercapnic hyperventilation, minute ventilation also increased (to 19.7 ± 1.7 l/min) as did end-tidal CO2 (both P < 0.0001). MSNA remained unchanged during isocapnic hyperventilation (104 ± 7%) but increased to 241 ± 49% during hypercapnic hyperventilation ( P < 0.01). RR decreased during both isocapnic and hypercapnic hyperventilation ( P < 0.05). However, normalized LF variability of RR and of MSNA decreased ( P < 0.05) during both isocapnic and hypercapnic hyperventilation, despite the tachycardia and heightened sympathetic nerve traffic. In conclusion, marked respiratory oscillations in autonomic drive induced by hyperventilation may induce dissociation between RR, MSNA, and neurocirculatory variability, perhaps by suppressing central genesis and/or inhibiting transmission of LF cardiovascular rhythms.

Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial

2011 ◽  
Vol 300 (1) ◽  
pp. E37-E45 ◽  
Author(s):  
Elizabeth Jedel ◽  
Fernand Labrie ◽  
Anders Odén ◽  
Göran Holm ◽  
Lars Nilsson ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Controlled Trial ◽  
Low Frequency ◽  
Reproductive Age ◽  
Secondary Outcome ◽  
Total Testosterone ◽  
Ovary Syndrome

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism, oligo/amenorrhea, and polycystic ovaries. We aimed to determine whether low-frequency electro-acupuncture (EA) would decrease hyperandrogenism and improve oligo/amenorrhea more effectively than physical exercise or no intervention. We randomized 84 women with PCOS, aged 18–37 yr, to 16 wk of low-frequency EA, physical exercise, or no intervention. The primary outcome measure changes in the concentration of total testosterone (T) at week 16 determined by gas and liquid chromatography-mass spectrometry was analyzed by intention to treat. Secondary outcome measures were changes in menstrual frequency; concentrations of androgens, estrogens, androgen precursors, and glucuronidated androgen metabolites; and acne and hirsutism. Outcomes were assessed at baseline, after 16 wk of intervention, and after a 16-wk follow-up. After 16 wk of intervention, circulating T decreased by −25%, androsterone glucuronide by −30%, and androstane-3α,17β-diol-3-glucuronide by −28% in the EA group ( P = 0.038, 0.030, and 0.047, respectively vs. exercise); menstrual frequency increased to 0.69/month from 0.28 at baseline in the EA group ( P = 0.018 vs. exercise). After the 16-wk follow-up, the acne score decreased by −32% in the EA group ( P = 0.006 vs. exercise). Both EA and exercise improved menstrual frequency and decreased the levels of several sex steroids at week 16 and at the 16-wk follow-up compared with no intervention. Low-frequency EA and physical exercise improved hyperandrogenism and menstrual frequency more effectively than no intervention in women with PCOS. Low-frequency EA was superior to physical exercise and may be useful for treating hyperandrogenism and oligo/amenorrhea.

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