P1.7 Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

2009 ◽  
Vol 149 (1-2) ◽  
pp. 62
Author(s):  
Y.B. Sverrisdottir ◽  
T. Mogren ◽  
J. Kataoka ◽  
P.O. Janson ◽  
E. Stener-Victorin
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Size At Birth

Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

2008 ◽  
Vol 294 (3) ◽  
pp. E576-E581 ◽  
Author(s):  
Yrsa Bergmann Sverrisdóttir ◽  
Tove Mogren ◽  
Josefin Kataoka ◽  
Per Olof Janson ◽  
Elisabet Stener-Victorin
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Study Groups ◽  
Reproductive Age ◽  
Burst Frequency ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Size At Birth

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disturbance among women of reproductive age and is proposed to be linked with size at birth and increased prevalence of cardiovascular disease. A disturbance in the sympathetic nervous system may contribute to the etiology of PCOS. This study evaluates sympathetic outflow in PCOS and its relation to size at birth. Directly recorded sympathetic nerve activity to the muscle vascular bed (MSNA) was obtained in 20 women with PCOS and in 18 matched controls. Ovarian ultrasonographic evaluation, biometric, hormonal, and biochemical parameters were measured, and birth data were collected. Women with PCOS had increased MSNA (30 ± 8 vs. 20 ± 7 burst frequency, P < 0.0005) compared with controls. MSNA was positively related to testosterone ( r = 0.63, P < 0.005) and cholesterol ( r = 0.55, P = 0.01) levels in PCOS, which, in turn, were not related to each other. Testosterone level was a stronger predictor of MSNA than cholesterol. Birth size did not differ between the study groups. This is the first study to directly address sympathetic nerve activity in women with PCOS and shows that PCOS is associated with high MSNA. Testosterone and cholesterol levels are identified as independent predictors of MSNA in PCOS, although testosterone has a stronger impact. The increased MSNA in PCOS may contribute to the increased cardiovascular risk and etiology of the condition. In this study, PCOS was not related to size at birth.

Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome

2011 ◽  
Vol 36 (10) ◽  
pp. 1470-1479 ◽  
Author(s):  
Elizabeth Jedel ◽  
Deborah Gustafson ◽  
Margda Waern ◽  
Yrsa Bergmann Sverrisdottir ◽  
Mikael Landén ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Sex Steroids ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Affective Symptoms

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome

2009 ◽  
Vol 297 (2) ◽  
pp. R387-R395 ◽  
Author(s):  
Elisabet Stener-Victorin ◽  
Elizabeth Jedel ◽  
Per Olof Janson ◽  
Yrsa Bergmann Sverrisdottir
Keyword(s):  
Physical Exercise ◽  
Sympathetic Nerve ◽  
Untreated Control ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
Muscle Sympathetic Nerve Activity ◽  
Low Frequency ◽  
Control Group ◽  
Burst Frequency ◽  
Nerve Activity

We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA ( n = 9), physical exercise ( n = 5), or untreated control ( n = 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA ( P = 0.036) and physical exercise ( P = 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter ( P = 0.001), while the physical exercise group reduced body weight ( P = 0.004) and body mass index ( P = 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency ( Rs = 0.58, P < 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS.

scholarly journals Heat therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome

2019 ◽  
Vol 317 (5) ◽  
pp. R630-R640 ◽  
Author(s):  
Brett R. Ely ◽  
Michael A. Francisco ◽  
John R. Halliwill ◽  
Samantha D. Bryan ◽  
Lindan N. Comrada ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Wall Thickness ◽  
Sympathetic Nerve Activity ◽  
Polycystic Ovary ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Nerve Activity ◽  
Reactive Protein ◽  
Heat Therapy ◽  
Over Time

Polycystic ovary syndrome (PCOS) affects up to 15% of women and is associated with increased risk of obesity and cardiovascular disease. Repeated passive heat exposure [termed “heat therapy” (HT)] is a lifestyle intervention with the potential to reduce cardiovascular risk in obesity and PCOS. Women with obesity ( n = 18) with PCOS [age 27 ± 4 yr, body mass index (BMI) 41.3 ± 4.7 kg/m2] were matched for age and BMI, then assigned to HT ( n = 9) or time control (CON; n = 9). HT subjects underwent 30 one-hour hot tub sessions over 8–10 wk, whereas CON subjects did not undergo HT. Muscle sympathetic nerve activity (MSNA), blood pressure, cholesterol, C-reactive protein, and markers of vascular function were assessed at the start (Pre) and end (Post) of 8–10 wk. These measures included carotid and femoral artery wall thickness and flow-mediated dilation (FMD), measured both before and after 20 min of ischemia-20 min of reperfusion (I/R) stress. HT subjects exhibited reduced MSNA burst frequency (Pre: 20 ± 8 bursts/min, Post: 13 ± 5 bursts/min, P = 0.012), systolic (Pre: 124 ± 5 mmHg, Post: 114 ± 6 mmHg; P < 0.001) and diastolic blood pressure (Pre: 77 ± 6 mmHg, Post: 68 ± 3 mmHg; P < 0.001), C-reactive protein (Pre: 19.4 ± 13.7 nmol/L, Post: 15.2 ± 12.3 nmol/L; P = 0.018), total cholesterol (Pre: 5.4 ± 1.1 mmol/L, Post: 5.0 ± 0.8 mmol/L; P = 0.028), carotid wall thickness (Pre: 0.054 ± 0.005 cm, Post: 0.044 ± 0.005 cm; P = 0.010), and femoral wall thickness (Pre: 0.056 ± 0.009 cm, Post: 0.042 ± 0.005 cm; P = 0.003). FMD significantly improved in HT subjects over time following I/R (Pre: 5.6 ± 2.5%, Post: 9.5 ± 1.7%; P < 0.001). No parameters changed over time in CON, and BMI did not change in either group. These findings indicate that HT reduces sympathetic nerve activity, provides protection from I/R stress, and substantially improves cardiovascular risk profiles in women who are obese with PCOS.

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