Reduced Abdominal Aortic Aneurysm Growth Rate in Diabetic Patients Treated by Metformin: A Potential Role of Chemokines?

2021 ◽  
Vol 70 ◽  
pp. e1-e2
Author(s):  
Juliette Raffort ◽  
Fabien Lareyre
Keyword(s):  
Growth Rate ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Diabetic Patients ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Metformin Prescription Associated with Reduced Abdominal Aortic Aneurysm Growth Rate and Reduced Chemokine Expression in a Swedish Cohort

2021 ◽  
Vol 70 ◽  
pp. 425-433 ◽  
Author(s):  
Jon Unosson ◽  
Dick Wågsäter ◽  
Niclas Bjarnegård ◽  
Rachel De Basso ◽  
Martin Welander ◽  
...  
Keyword(s):  
Growth Rate ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Chemokine Expression ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Swedish Cohort

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

2013 ◽  
Vol 228 (2) ◽  
pp. 295-305 ◽  
Author(s):  
Smriti Murali Krishna ◽  
Anthony Dear ◽  
Jeffrey M. Craig ◽  
Paul E. Norman ◽  
Jonathan Golledge
Keyword(s):  
Dna Methylation ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Epigenetic Changes ◽  
Aneurysm Formation ◽  
Abdominal Aortic

Diabetes and Its Effect on Abdominal Aortic Aneurysm Growth Rate in Hispanic Patients

2019 ◽  
Vol 61 ◽  
pp. 254-260
Author(s):  
Monica M. Betancourt-Garcia ◽  
Kristina Vatcheva ◽  
Amrit Thakur ◽  
Prateek K. Gupta ◽  
Eugene Postevka ◽  
...  
Keyword(s):  
Growth Rate ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
Hispanic Patients ◽  
Aneurysm Growth

Prognostic and predictive biomarkers of abdominal aortic aneurysm growth rate

2016 ◽  
Vol 32 (3) ◽  
pp. 509-517 ◽  
Author(s):  
Mark A. Deeg ◽  
C. Arnoud Meijer ◽  
Lai Shan Chan ◽  
Lei Shen ◽  
Jan H. N. Lindeman
Keyword(s):  
Growth Rate ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Predictive Biomarkers ◽  
Abdominal Aortic ◽  
Aneurysm Growth

scholarly journals Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Yingying Zhou ◽  
Jiaoni Wang ◽  
Yangjing Xue ◽  
Aili Fang ◽  
Shaoze Wu ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Macrophage Activation ◽  
Potential Role ◽  
Biological Function ◽  
Cascade Reactions ◽  
Fatal Disease ◽  
Abdominal Aortic ◽  
Activated Macrophage

Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA. We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA. We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown. Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage. A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed. The function of differential mRNAs was determined by pathway and Gene Ontology analysis. Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated. It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation. Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.

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