scholarly journals Sex differences in the IQ-white matter microstructure relationship: A DTI study

2014 ◽  
Vol 91 ◽  
pp. 71-78 ◽  
Author(s):  
Beate Dunst ◽  
Mathias Benedek ◽  
Karl Koschutnig ◽  
Emanuel Jauk ◽  
Aljoscha C. Neubauer
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
White Matter Microstructure

Sex differences in frontal lobe white matter microstructure: a DTI study

Neuroreport ◽  
2003 ◽  
Vol 14 (18) ◽  
pp. 2469-2473 ◽  
Author(s):  
Philip R. Szeszko ◽  
Joshua Vogel ◽  
Manzar Ashtari ◽  
Anil K. Malhotra ◽  
John Bates ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Frontal Lobe ◽  
White Matter Microstructure

scholarly journals Cerebral White Matter Sex Dimorphism in Alcoholism: A Diffusion Tensor Imaging Study

2017 ◽  
Author(s):  
Kayle S. Sawyer ◽  
Nasim Maleki ◽  
George Papadimitriou ◽  
Nikos Makris ◽  
Marlene Oscar-Berman ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Brain Regions ◽  
Cerebral White Matter ◽  
Excessive Alcohol Consumption ◽  
White Matter Microstructure ◽  
White Matter Connectivity

AbstractBackgroundExcessive alcohol consumption is associated with widespread brain damage, including abnormalities in frontal and limbic brain regions. In a prior study of neuronal circuitry connecting the frontal lobes and limbic system structures in abstinent alcoholic men, we demonstrated decreases in white matter fractional anisotropy (FA) on diffusion tensor magnetic resonance imaging (dMRI). In the present study, we examined sex differences in alcoholism-related abnormalities of white matter connectivity.MethodsdMRI scans were acquired from 49 abstinent alcoholic individuals (26 women) and 41 nonalcoholic controls (22 women). Tract-based spatial statistical tools were used to estimate regional FA of white matter tracts and to determine sex differences and their relation to measures of alcoholism history.ResultsSex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum, the superior longitudinal fasciculi II and III, and the arcuate fasciculus and extreme capsule. In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety.ConclusionsSexual dimorphism in white matter microstructure in abstinent alcoholics may implicate underlying differences in the neurobehavioral liabilities for developing alcohol abuse disorders, or for sequelae following abuse.

scholarly journals Sex differences in the effects of gonadal hormones on white matter microstructure development in adolescence

2020 ◽  
Vol 42 ◽  
pp. 100773 ◽  
Author(s):  
Tiffany C. Ho ◽  
Natalie L. Colich ◽  
Lucinda M. Sisk ◽  
Kira Oskirko ◽  
Booil Jo ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Gonadal Hormones ◽  
Microstructure Development ◽  
White Matter Microstructure

Sex differences in the relationship between white matter microstructure and impulsivity in adolescents

2006 ◽  
Vol 24 (7) ◽  
pp. 833-841 ◽  
Author(s):  
Marisa M. Silveri ◽  
Michael L. Rohan ◽  
Patricia J. Pimentel ◽  
Staci A. Gruber ◽  
Isabelle M. Rosso ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
White Matter Microstructure ◽  
The Relationship

scholarly journals Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure

2016 ◽  
pp. bhw156 ◽  
Author(s):  
J. van Hemmen ◽  
I. M. J. Saris ◽  
P. T. Cohen-Kettenis ◽  
D. J. Veltman ◽  
P. J. W. Pouwels ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Human Brain ◽  
Sex Hormone ◽  
White Matter Microstructure ◽  
Hormone Exposure

scholarly journals Sex differences in the effects of gonadal hormones on white matter microstructure development in adolescence

2019 ◽  
Author(s):  
Tiffany C. Ho ◽  
Kira Oskirko ◽  
Natalie L. Colich ◽  
Lucinda M. Sisk ◽  
Ian H. Gotlib
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Brain Development ◽  
Gonadal Hormones ◽  
Linear Regression Models ◽  
Pubertal Stage ◽  
White Matter Microstructure ◽  
Control Response ◽  
And Diffusion ◽  
Pubertal Transition

AbstractAdolescence, the transition between childhood and adulthood, is characterized by rapid brain development in white matter (WM) that is attributed in part to surges in gonadal hormones. To date, however, there have been no longitudinal investigations of the effects of gonadal hormones on WM development in adolescents. We acquired T1-weighted and diffusion-weighted MRIs at two timepoints and saliva samples from 80 adolescents (52 females [11.10±1.05 years at Time 1; 12.75±1.37 years at Time 2] and 28 males [ages 11.91±0.88 years at Time 1; 13.79±0.95 years at Time 2] who were matched on pubertal stage at Time 1. We estimated mean fractional anisotropy (FA) from 10 major WM tracts and assayed levels of testosterone (in both sexes) and estradiol (in females only). We used linear regression models to test whether interactions between sex and changes in testosterone levels significantly explained changes in FA. Sex significantly moderated the associations between changes in testosterone and changes in FA within the corpus callosum, inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), and cingulum cingulate (all ps<0.05): whereas these associations were positive in females, they were not significant in males. Females also exhibited positive associations between changes in estradiol and changes in UF, IFOF, and corticospinal FA (all ps<0.05). Our findings indicate that sex differences in WM microstructure of tracts supporting cognitive control, response inhibition, and emotion regulation are explained by differences in changes in testosterone, and have important implications for understanding sex differences in brain development and psychosocial behaviors during the pubertal transition.

scholarly journals White matter microstructure shows sex differences in late childhood: Evidence from 6,797 children

2021 ◽  
Author(s):  
Katherine E. Lawrence ◽  
Zvart Abaryan ◽  
Emily Laltoo ◽  
Leanna M. Hernandez ◽  
Michael Gandal ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Diffusion Tensor ◽  
Adult Brain ◽  
Neurite Density ◽  
White Matter Microstructure ◽  
White Matter Region ◽  
Weighted Magnetic Resonance Imaging ◽  
Health And Disease ◽  
The Impact

AbstractSex differences in white matter microstructure have been robustly demonstrated in the adult brain using both conventional and advanced diffusion-weighted magnetic resonance imaging (dMRI) approaches. However, the effect of sex on white matter microstructure prior to adulthood remains poorly understood, with previous developmental work focusing on conventional microstructure metrics and yielding mixed results. Here we thoroughly and rigorously characterized sex differences in white matter microstructure among over 6,000 children from the Adolescent Brain Cognitive Development (ABCD) Study who were between 9 and 10 years old. Microstructure was quantified using both the conventional model - diffusion tensor imaging (DTI) - and an advanced model, restriction spectrum imaging (RSI). DTI metrics included fractional anisotropy (FA) and mean, axial, and radial diffusivity (MD, AD, RD). RSI metrics included normalized isotropic, directional, and total intracellular diffusion (N0, ND, NT). We found significant and replicable sex differences in DTI or RSI microstructure metrics in every white matter region examined across the brain. The impact of sex on FA was regionally specific. Across white matter regions, boys exhibited greater MD, AD, and RD than girls, on average. Girls displayed increased N0, ND, and NT compared to boys, on average, suggesting greater cell and neurite density in girls. Together, these robust and replicable findings provide an important foundation for understanding sex differences in health and disease.

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