scholarly journals Can body composition measures on computed tomography predict mortality in patients with spinal metastases undergoing surgery?

2021 ◽  
Vol 1 ◽  
pp. 100049
Author(s):  
Olivier Groot ◽  
Michiel Bongers ◽  
Colleen Buckless ◽  
Neal Kapoor ◽  
Peter Twining ◽  
...  
2021 ◽  
Vol 1 ◽  
pp. 100115
Author(s):  
Olivier Groot ◽  
Neal Kapoor ◽  
Colleen Buckless ◽  
peter Twining ◽  
Michiel Bongers ◽  
...  

2021 ◽  
Author(s):  
Ludmila Koch ◽  
Andrea Z Pereira ◽  
Nelson Hamerschlak ◽  
Adham do Amaral e Castro ◽  
Adriano Tachibana ◽  
...  

Abstract Aim: The incidence of most hematologic malignancies increases with age. Hematopoietic stem cell transplantation (HSCT) provides a potentially life-prolonging or curative option for many patients in this scenario. Limited data is available on muscle mass and density assessed from CT-images on outcomes after HSCT. We aimed to evaluate the influence of body composition on morbidity and mortality in older adults undergoing (HSCT). Methods: Retrospective longitudinal study conducted with 50 patients ≥ 60 years undergoing HSCT at Hospital Israelita Albert Einstein, São Paulo. Body composition was assessed by chest computed tomography and treatment related mortality, graft versus host disease, neutrophil grafting, and overall survival were analyzed.Results: 148 HSCT patients were evaluated, 50 patients were eligible: 60% with autologous and 40% with allogeneic transplantation. Body mass index in patients was (female: 26.9 ± 4.7 kg/m2; 30.1± 4.9 kg/m2) - autologous and (female: 24.3 ± 5.15 kg/m2; male: 26.4 ± 2.0 kg/m2) - allogeneic. In autologous transplant group, we found a positive association between age and death risk with an increase of 63.5% in this risk (p=0.006) and also Karnofsky performance scale with decrease of 11.9% in death risk (p<0.001). A negative association between muscle radiodensity and death risk was observed in allogeneic transplantation patients with risk decrease of 20.1% (p = 0.032). We found a positive association between T4 muscle area and radiodensity with risk of acute graft versus host disease (p= 0.028). Conclusion: In population studied, body composition assessed by chest tomography showed the importance of radiodensity for better prognosis.


2016 ◽  
Vol 35 ◽  
pp. S16
Author(s):  
K.E. Rollins ◽  
H. Javanmard-Emamghissi ◽  
A. Awwad ◽  
I.A. Macdonald ◽  
K.C. Fearon ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Young Seo Cho ◽  
Ha Young Lee ◽  
Jae Yoon Jeong ◽  
Jae Gon Lee ◽  
Tae Yeob Kim ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1864
Author(s):  
Jongsoo Lee ◽  
Jee Soo Park ◽  
Ji Eun Heo ◽  
Hyun Kyu Ahn ◽  
Won Sik Jang ◽  
...  

Limited studies have investigated the correlation between body composition and prostate cancer outcomes. We analyzed the effect of muscle mass and quality on castration-resistant prostate cancer (CRPC) outcomes. Skeletal muscle index (SMI) and skeletal muscle attenuation (SMA) were measured for 411 patients at the L3 vertebral level using computed tomography at CRPC diagnosis and were dived to low and high groups at the value of median. Analysis of the skeletal phenotypes and age (<70 and >70 years) was performed to evaluate the effect of SMI and SMA. The median survival rates for patients with low and high SMI were 19 and 24 months (p = 0.015), and those with low and high SMAs were 15 and 26 months (p < 0.001), respectively. In the subgroup analysis by age, SMA was a significant prognosticator in both groups, while SMI was a significant prognosticator only in patients aged >70 years. Patients with low SMA + low SMI had the worst prognosis. Muscle characteristics seems to be a prognosticator in survival of CRPC patients and may be considered in treatment planning.


2020 ◽  
Vol 33 (12) ◽  
pp. 1610-1625
Author(s):  
Dmitry Rozenberg ◽  
Camila E. Orsso ◽  
Karan Chohan ◽  
Ani Orchanian‐Cheff ◽  
Sahar Nourouzpour ◽  
...  

2018 ◽  
Vol 97 (11) ◽  
pp. 4093-4106 ◽  
Author(s):  
Marine F Dewez ◽  
Patrice Etourneau ◽  
François Lecompte ◽  
Sylvain Briere ◽  
Pascal Froment

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