Selenoprotein S silencing triggers mouse hepatoma cells apoptosis and necrosis involving in intracellular calcium imbalance and ROS-mPTP-ATP

2018 ◽  
Vol 1862 (10) ◽  
pp. 2113-2123 ◽  
Author(s):  
Xiaojing Li ◽  
Menghao Chen ◽  
Zijiang Yang ◽  
Wei Wang ◽  
Hongjin Lin ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Hepatoma Cells ◽  
Selenoprotein S ◽  
Mouse Hepatoma ◽  
Apoptosis And Necrosis

Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells

2016 ◽  
Vol 397 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Nicola Groll ◽  
Ferdinand Kollotzek ◽  
Jens Goepfert ◽  
Thomas O. Joos ◽  
Michael Schwarz ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Regulation ◽  
Antiepileptic Drug ◽  
Signaling Pathway ◽  
Constitutive Androstane Receptor ◽  
Hepatoma Cells ◽  
Liver Cells ◽  
Mrna Levels ◽  
Calpain Activity ◽  
Mouse Hepatoma

Abstract The antiepileptic drug phenobarbital (PB) exerts hepatic effects related to cell proliferation and tumorigenesis which are closely linked to the Wnt/β-catenin signaling pathway. This pathway is, amongst others, regulated by calpain proteases. We now identified PB as an inhibitor of Wnt/β-catenin signaling in mouse hepatoma cells. Further analyses revealed that PB inhibits calpain activity, an effect which is at least in parts mediated by a transcriptional regulation of calpain mRNA levels and which is furthermore independent of the constitutive androstane receptor, the known mediator of most effects of PB in liver cells.

Enzyme Induction by L-Buthionine(S,R)-Sulfoximine in Cultured Mouse Hepatoma Cells

1995 ◽  
Vol 8 (3) ◽  
pp. 431-436 ◽  
Author(s):  
Howard G. Shertzer ◽  
Vasilis Vasiliou ◽  
Rui-Ming Liu ◽  
M. Wilson Tabor ◽  
Daniel W. Nebert
Keyword(s):  
Enzyme Induction ◽  
Hepatoma Cells ◽  
Mouse Hepatoma

Enhanced Hepatic Functions of Genetically Modified Mouse Hepatoma Cells by Spheroid Culture for Drug Toxicity Screening

2017 ◽  
Vol 12 (10) ◽  
pp. 1700274 ◽  
Author(s):  
Joyita Sarkar ◽  
Jyoti Kumari ◽  
Jane M. Tonello ◽  
Masamichi Kamihira ◽  
Ashok Kumar
Keyword(s):  
Drug Toxicity ◽  
Genetically Modified ◽  
Hepatoma Cells ◽  
Toxicity Screening ◽  
Spheroid Culture ◽  
Mouse Hepatoma

Cytotoxicity of N6-Cycloalkylated Adenine and Adenosine Analogs to Mouse Hepatoma Cells

Pathobiology ◽  
1989 ◽  
Vol 57 (2) ◽  
pp. 53-59
Author(s):  
Roosevelt Thedford ◽  
Eniola O. Leyimu ◽  
Dedra L. Thornton ◽  
Rajen Mehta
Keyword(s):  
Hepatoma Cells ◽  
Adenosine Analogs ◽  
Mouse Hepatoma

Generation and characterization of variants of mouse hepatoma cells with defects in hepato-specific gene expression. I. Albumin synthesis variants

1982 ◽  
Vol 8 (4) ◽  
pp. 451-464 ◽  
Author(s):  
Gretchen J. Darlington ◽  
John Papaconstantinou ◽  
David W. Sammons ◽  
Peter C. Brown ◽  
Edith Y. Wong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatoma Cells ◽  
Specific Gene ◽  
Albumin Synthesis ◽  
Specific Gene Expression ◽  
Mouse Hepatoma
Sign in / Sign up

Export Citation Format

Share Document