Cholesterol acceptor capacity is preserved by different mechanisms in preterm and term fetuses

2014 ◽  
Vol 1841 (2) ◽  
pp. 251-258 ◽  
Author(s):  
Ulrich Pecks ◽  
Markus G. Mohaupt ◽  
Matthias C. Hütten ◽  
Nicolai Maass ◽  
Werner Rath ◽  
...  
Keyword(s):  
Acceptor Capacity

scholarly journals Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses

2017 ◽  
Vol 45 (7) ◽  
Author(s):  
Ulrich Pecks ◽  
Werner Rath ◽  
Dirk O. Bauerschlag ◽  
Nicolai Maass ◽  
Thorsten Orlikowsky ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Intrauterine Growth Restriction ◽  
Cholesterol Efflux ◽  
Independent Risk Factor ◽  
Cholesterol Transport ◽  
Vascular Risk ◽  
Transport Mechanisms ◽  
Intrauterine Growth ◽  
Acceptor Capacity

AbstractAim:Intrauterine growth restriction (IUGR) is an independent risk factor for the development of cardiovascular diseases later in life. The mechanisms whereby slowed intrauterine growth confers vascular risk are not clearly established. In general, a disturbed cholesterol efflux has been linked to atherosclerosis. The capacity of serum to accept cholesterol has been repeatedly evaluated in clinical studies by the use of macrophage-based cholesterol efflux assays and, if disturbed, precedes atherosclerotic diseases years before the clinical diagnosis. We now hypothesized that circulating cholesterol acceptors in IUGR sera specifically interfere with cholesterol transport mechanisms leading to diminished cholesterol efflux.Methods:RAW264.7 cells were used to determine efflux of [Results:Cholesterol efflux was lower in IUGR as compared to controls [controls: mean 7.7% fractional [Conclusions:Reduced cholesterol efflux in IUGR could account for the enhanced risk of developing cardiovascular diseases later in life.

Metallkomplexe mit Tetrapyrrol-Liganden, XIX [1]. Synthese und elektrochemische Charakterisierung der Kohlenmonosulfid-Metalloctaethylporphyrine mit Eisen(II) oder Osmium(II) im Zentrum. Ein Beitrag zur "Bathochromie-Regel" / Metal Complexes with Tetrapyrrole Ligands, XIX [1]. Synthesis and Electrochemical Characterization of Thiocarbonyl Metallooctaethylporphyrins with Iron(II) or Osmium(II) in the Center. A Contribution to the "Rule of Bathochromism"

1978 ◽  
Vol 33 (12) ◽  
pp. 1371-1380 ◽  
Author(s):  
Johann W. Buchler ◽  
Wolfgang Kokisch ◽  
Paul D. Smith ◽  
Bernhard Tonn
Keyword(s):  
Metal Complexes ◽  
Linear Correlation ◽  
Optical Spectrum ◽  
Spectroscopic Characterization ◽  
Electrochemical Characterization ◽  
Redox Potentials ◽  
Acceptor Capacity ◽  
Α Band

The preparation and spectroscopic characterization of thiocarbonyl metalloporphyrins M(OEP)CS(L') (e.g. 2e: M = Fe, L' = Py, 1e: M = Os, L' = Py** are described. Especially noteworthy is the existence of a pentacoordinate, diamagnetic, air-stable heme Fe(OEP)CS (2f: M = Fe, no L′). A linear correlation of the α-band frequencies (expressed as ϋa) in the optical spectrum and the metal(II/III) redox potentials (E1/2) taken from cyclic voltam­metry experiments suggests (Abb. 3) that in complexes of the type M(OEP)LL' (1,2) λa is bathochromically shifted as the π-acceptor capacity of L increases (“Rule of Bathochromism”). The strong π-acceptor capacity of carbon monosulphide renders the attack of dioxygen to the thiocarbonyl heme unfavourable; O2 and CS seem to be comparable in their π-acceptor strength.

scholarly journals Effects of liver regeneration on tRNA contents and aminoacyl-tRNA synthetase activities and sedimentation patterns

1986 ◽  
Vol 236 (1) ◽  
pp. 163-169 ◽  
Author(s):  
U Del Monte ◽  
S Capaccioli ◽  
G Neri Cini ◽  
R Perego ◽  
R Caldini ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Cultured Cells ◽  
Trna Synthetase ◽  
Synthetase Activity ◽  
Regenerating Liver ◽  
Trna Synthetases ◽  
Aminoacyl Trna Synthetases ◽  
Acceptor Capacity ◽  
Increased Activity

The tRNA content and aminoacyl-tRNA synthetases of regenerating liver in the phase of rapid growth were compared with those of livers from both intact and sham-operated rats. At 48 h after hepatectomy, the amount of active tRNA (called ‘total acceptor capacity’) is significantly higher in regenerating liver than in control livers, owing to a general, possibly not uniform, increase in the various tRNA families, which suggests that it may contribute to the increased protein synthesis and to decreased protein degradation as well. The activities of most, but not of all, aminoacyl-tRNA synthetases in cell sap of regenerating liver tend to be greater than normal. Increased activity of histidyl-tRNA synthetase fits in with the possibility that the mechanisms that control the rate of protein degradation through aminoacylation of tRNAHis in cultured cells [Scornik (1983) J. Biol. Chem. 258, 882-886] also operate in the liver and play a role in regeneration. Sedimentation analysis of cell sap in sucrose density gradients shows a shift of prolyl-tRNA synthetase activity toward the high-Mr form in regenerating liver. This change might be related to the positive protein balance and to growth in vivo, since it is also observed in the anaplastic Yoshida ascites hepatoma AH 130.

Hydrogen Bonding Contribution to Lipophilicity Parameters. Hydrogen Acceptor and Hydrogen Acceptor Donor Parameters

2004 ◽  
Vol 69 (12) ◽  
pp. 2147-2173 ◽  
Author(s):  
Marvin Charton ◽  
Barbara I. Charton
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonding ◽  
Hydrogen Bonds ◽  
Reasonable Assumption ◽  
Hydrogen Acceptor ◽  
Donor Capacity ◽  
The Difference ◽  
Acceptor Capacity ◽  
Lipophilicity Parameters ◽  
Hydrogen Bond Energies

In our analysis of the composition of lipophilicity parameters by the intermolecular force (IMF) model we have made use of nH, the number of OH and/or NH bonds, as a measure of the hydrogen donor capacity of a substituent; and nn, the number of lone pairs on O and/or N atoms in the substituent, as a measure of the hydrogen acceptor capacity of the substituent. The basis of this method is the reasonable assumption that in 55.6 molar water hydrogen bonding is maximized. The method does not account however for differences in the energy of different types of hydrogen bonds, but further assumes that these differences are to a first approximation negligible. In order to improve the model we have defined a scale of group hydrogen bonding acceptor parameters, ηXHA, and overall hydrogen bond parameters ηXHAD from the water/1-octanol partition coefficients of AkX where Ak is alkyl. These parameters should account for both the extent of hydrogen bonding in water and for the difference in hydrogen bond energies of the various types of hydrogen bonds encountered. Correlations of log P values for Ph(CH2)nX, X1(CH2)X2, and substituted amino acids Xaa with the IMF equation using the ηXHA and ηXHAD parameters demonstrated their use. Correlation of log P values for PhX suggested that for many groups separate sets of ηXHA and ηXHAD values are required when they are bonded to sp2 hybridized carbon rather than sp3 hybridized carbon.

Metallkomplexe mit Tetrapyrrol-Liganden, XVIII* Osmiumkomplexe des meso-Tetra(p-tolyl)porphyrins / Metal Complexes with Tetrapyrrole Ligands, XVIII* Osmium Complexes of meso-Tetra(p-tolyl)porphyrin

1977 ◽  
Vol 32 (12) ◽  
pp. 1439-1448 ◽  
Author(s):  
Johann W. Buchler ◽  
Manfred Folz
Keyword(s):  
Metal Complexes ◽  
Spectroscopic Characterization ◽  
Porphyrin Ligand ◽  
Osmium Complexes ◽  
Acceptor Capacity

The preparation and spectroscopic characterization of osmium tetra(p-tolyl)porphyrin complexes, Os(TTP)LL′ (2c-21; L or L′ = CO, N2, EtOH, THF, Py, PPh3, P(OMe)3, methoxide or oxide) are described. 2c-21 are compared with the analogous octaethylporphyrin complexes, 1c-11. In 2c-21, the porphyrin ligand is a stronger π-acceptor than in 1c-11. The π-acceptor capacity of the porphyrin ligand renders the dinitrogenosmium(II) porphyrins 1j or 2j less stable than the dinitrogenpentammineosmium(II) cation.

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