scholarly journals Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae

2007 ◽  
Vol 1773 (8) ◽  
pp. 1311-1340 ◽  
Author(s):  
Raymond E. Chen ◽  
Jeremy Thorner
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Lessons Learned ◽  
Yeast Saccharomyces Cerevisiae ◽  
Mapk Signaling Pathways

scholarly journals Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action

2020 ◽  
Vol 22 (1) ◽  
pp. 167
Author(s):  
Prajita Pandey ◽  
Khadiza Zaman ◽  
Laszlo Prokai ◽  
Vladimir Shulaev
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Signaling Pathways ◽  
Mechanism Of Action ◽  
Mapk Signaling ◽  
Comparative Proteomics ◽  
Mass Analyzer ◽  
Label Free ◽  
Proteomics Analysis ◽  
Yeast Saccharomyces Cerevisiae ◽  
Signaling Mechanism

The early signaling events involved in oxidant recognition and triggering of oxidant-specific defense mechanisms to counteract oxidative stress still remain largely elusive. Our discovery driven comparative proteomics analysis revealed unique early signaling response of the yeast Saccharomyces cerevisiae on the proteome level to oxidants with a different mechanism of action as early as 3 min after treatment with four oxidants, namely H2O2, cumene hydroperoxide (CHP), and menadione and diamide, when protein abundances were compared using label-free quantification relying on a high-resolution mass analyzer (Orbitrap). We identified significant regulation of 196 proteins in response to H2O2, 569 proteins in response to CHP, 369 proteins in response to menadione and 207 proteins in response to diamide. Only 17 proteins were common across all treatments, but several more proteins were shared between two or three oxidants. Pathway analyses revealed that each oxidant triggered a unique signaling mechanism associated with cell survival and repair. Signaling pathways mostly regulated by oxidants were Ran, TOR, Rho, and eIF2. Furthermore, each oxidant regulated these pathways in a unique way indicating specificity of response to oxidants having different modes of action. We hypothesize that interplay of these signaling pathways may be important in recognizing different oxidants to trigger different downstream MAPK signaling cascades and to induce specific responses.

scholarly journals Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae

2011 ◽  
Vol 193 (4) ◽  
pp. 755-767 ◽  
Author(s):  
Kai Mao ◽  
Ke Wang ◽  
Mantong Zhao ◽  
Tao Xu ◽  
Daniel J. Klionsky
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Signaling Pathways ◽  
Energy Production ◽  
Mapk Signaling ◽  
Selective Degradation ◽  
Mitogen Activated Protein ◽  
Essential Function ◽  
Mapk Signaling Pathways ◽  
Assembly Site

Macroautophagy (hereafter referred to simply as autophagy) is a catabolic pathway that mediates the degradation of long-lived proteins and organelles in eukaryotic cells. The regulation of mitochondrial degradation through autophagy plays an essential role in the maintenance and quality control of this organelle. Compared with our understanding of the essential function of mitochondria in many aspects of cellular metabolism such as energy production and of the role of dysfunctional mitochondria in cell death, little is known regarding their degradation and especially how upstream signaling pathways control this process. Here, we report that two mitogen-activated protein kinases (MAPKs), Slt2 and Hog1, are required for mitophagy in Saccharomyces cerevisiae. Slt2 is required for the degradation of both mitochondria and peroxisomes (via pexophagy), whereas Hog1 functions specifically in mitophagy. Slt2 also affects the recruitment of mitochondria to the phagophore assembly site (PAS), a critical step in the packaging of cargo for selective degradation.

scholarly journals Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways

2021 ◽  
Vol 83 ◽  
pp. 104547
Author(s):  
Zhenzhen Cheng ◽  
Jingjing Tu ◽  
Hongpan Zhang ◽  
Yi zhang ◽  
Benhong Zhou
Keyword(s):  
Signaling Pathways ◽  
Renal Fibrosis ◽  
Mapk Signaling ◽  
Urolithin A ◽  
Mapk Signaling Pathways ◽  
Tgf Β1

6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 2192-2204 ◽  
Author(s):  
Chang Liu ◽  
Xin Tang ◽  
Wenjing Zhang ◽  
Guohong Li ◽  
Yingyu Chen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152104 ◽  
Author(s):  
Francesco Pappalardo ◽  
Giulia Russo ◽  
Saverio Candido ◽  
Marzio Pennisi ◽  
Salvatore Cavalieri ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Melanoma Cancer ◽  
Mapk Signaling Pathways

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 ◽  
Vol 20 (4) ◽  
pp. 151-156 ◽  
Author(s):  
J INGLESE ◽  
W KOCH ◽  
K TOUHARA ◽  
R LEFKOWITZ
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Ph Domains ◽  
Mapk Signaling Pathways
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