Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood

2009 ◽  
Vol 202 (2) ◽  
pp. 198-209 ◽  
Author(s):  
Richard J. Beninger ◽  
Katharine J. Tuerke ◽  
Jennifer K. Forsyth ◽  
Andrew Giles ◽  
Lihua Xue ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Water Maze ◽  
Glutamate Release ◽  
Female Rats ◽  
Male And Female ◽  
Prefrontal Cortical ◽  
Male And Female Rats ◽  
Plus Maze ◽  
Hippocampal Lesions

scholarly journals Oxycodone decreases anxiety-like behavior in the elevated plus-maze test in male and female rats

2021 ◽  
Author(s):  
Adriaan W. Bruijnzeel ◽  
Azin Behnood-Rod ◽  
Wendi Malphurs ◽  
Ranjithkumar Chellian ◽  
Robert M. Caudle ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Field Test ◽  
Elevated Plus Maze ◽  
Open Field Test ◽  
Female Rats ◽  
Male And Female ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Male And Female Rats ◽  
Plus Maze

AbstractThe prescription opioid oxycodone is widely used for the treatment of pain in humans. Oxycodone misuse is more common among people with an anxiety disorder than those without one. Therefore, oxycodone might be misused for its anxiolytic properties. We investigated if oxycodone affects anxiety-like behavior in adult male and female rats. The rats were treated with oxycodone (0.178, 0.32, 0.56, or 1 mg/kg), and anxiety-like behavior was investigated in the elevated plus-maze test. Immediately after the elevated plus-maze test, a small open field test was conducted to determine the effects of oxycodone on locomotor activity. In the elevated plus-maze test, oxycodone increased the percentage of time spent on the open arms, the percentage of open arm entries, time on the open arms, open arm entries, and the distance traveled. The males treated with vehicle had a lower percentage of open arm entries than the females treated with vehicle, and oxycodone treatment led to a greater increase in the percentage of open arm entries in the males than females. Furthermore, the females spent more time on the open arms, made more open arm entries, spent less time in the closed arms, and traveled a greater distance than the males. In the small open field test, treatment with oxycodone did not affect locomotor activity or rearing. Sex differences were observed; the females traveled a greater distance and displayed more rearing than the males. In conclusion, oxycodone decreases anxiety-like behavior in rats, and oxycodone has a greater anxiolytic-like effect in males than females.

scholarly journals Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin

2019 ◽  
Vol 33 (5) ◽  
pp. 640-646 ◽  
Author(s):  
Brian H Harvey ◽  
Wilmie Regenass ◽  
Walter Dreyer ◽  
Marisa Möller
Keyword(s):  
Social Isolation ◽  
Female Rats ◽  
Male Rats ◽  
Isolation Rearing ◽  
Male And Female ◽  
Plasma Vasopressin ◽  
Male And Female Rats ◽  
Plus Maze ◽  
Circadian Fluctuation ◽  
Social Isolation Rearing

Background: The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared (SIR) rats. Agomelatine was anxiolytic in this model but did not reverse hypocortisolemia. Reduced corticosterone or cortisol (in humans) is well-described in anxiety states, although the anxiolytic-like actions of agomelatine may involve targeting another mechanism. Central oxytocin and vasopressin exert anxiolytic and anxiogenic effects, respectively, and are subject to circadian fluctuation, while also showing sex-dependent differences in response to various challenges. Aims and methods: If corticosterone is less involved in the anxiolytic-like actions of agomelatine in SIR rats, we wondered whether effects on vasopressin and oxytocin may mediate these actions, and whether sex-dependent effects are evident. Anxiety as assessed in the elevated plus maze, as well as plasma vasopressin, oxytocin, and corticosterone were analyzed in social vs SIR animals receiving sub-chronic treatment with vehicle or agomelatine (40 mg/kg/day intraperitoneally at 16:00) for 16 days. Results: Social isolation rearing induced significant anxiety together with increased plasma vasopressin levels, but decreased corticosterone and oxytocin. While corticosterone displayed sex-dependent changes, vasopressin, and oxytocin changes were independent of sex. Agomelatine suppressed anxiety as well as reversed elevated vasopressin in both male and female rats and partially reversed reduced oxytocin in female but not male rats. Conclusion: SIR-associated anxiety later in life involves reduced corticosterone and oxytocin, and elevated vasopressin. The anxiolytic-like effects of agomelatine in SIR rats predominantly involve targeting of elevated vasopressin.

Dietary Soy Supplements Produce Opposite Effects on Anxiety in Intact Male and Female Rats in the Elevated Plus-Maze.

2005 ◽  
Vol 119 (2) ◽  
pp. 587-594 ◽  
Author(s):  
Heather B. Patisaul ◽  
Adele Blum ◽  
Jordan R. Luskin ◽  
Mark E. Wilson
Keyword(s):  
Elevated Plus Maze ◽  
Female Rats ◽  
Intact Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Plus Maze

scholarly journals A role for puberty in water maze performance in male and female rats.

2016 ◽  
Vol 130 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Jari Willing ◽  
Carly M. Drzewiecki ◽  
Bethany A. Cuenod ◽  
Laura R. Cortes ◽  
Janice M. Juraska
Keyword(s):  
Water Maze ◽  
Female Rats ◽  
Maze Performance ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway

2018 ◽  
Vol 8 (8) ◽  
pp. 141 ◽  
Author(s):  
Mouloud Lamtai ◽  
Jihane Chaibat ◽  
Sihame Ouakki ◽  
Oussama Zghari ◽  
Abdelhalem Mesfioui ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Chronic Administration ◽  
Female Rats ◽  
Spatial Learning And Memory ◽  
Cognitive Behavior ◽  
Male And Female ◽  
Male And Female Rats

Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each gender, divided into control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Morris Water Maze was used to evaluate the spatial learning and memory. The hippocampus of each animal was taken for biochemical examination. The results showed that Ni administration dose dependently increased anxiety-like behavior in both tests. A significant increase in depression-like symptoms was also exhibited by Ni treated rats. In the Morris Water Maze test, the spatial learning and memory were significantly impaired just in males treated with 1 mg/kg of Ni. With regard to biochemical analysis, activity of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased, while the levels of nitric oxide (NO) and lipid peroxidation (LPO) in the hippocampus were significantly increased in the Ni-treated groups. Consequently, chronic Ni administration induced behavioral and biochemical dysfunctions.

Manipulation Effects, Open-Field Experience and Digestive Transit Time in Wistar Male and Female Rats

1966 ◽  
Vol 19 (2) ◽  
pp. 375-378 ◽  
Author(s):  
Ethel Tobach
Keyword(s):  
Locomotor Activity ◽  
Open Field ◽  
Transit Time ◽  
Field Experience ◽  
The Other ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Field Situation ◽  
Old Rats

14 male and 16 female Wistar (DAB) 113-day-old rats were observed in an open-field situation, in their home cages after manipulation, and in home cages without manipulation. Incidences of defecation and urination, locomotor activity, and digestive transit time were recorded during 4-min. sessions for 6 days. Animals were more likely to eliminate in the open-field situation than in their home cages, and more rats eliminated in this group than in the other two groups. It appears that the effect of the open-field situation on eliminative behavior is not related to that of manipulation incident to the observation of the animal in the open field. The decrease in digestive transit time of animals placed in the open field further suggests that the open-field situation is more effective than manipulation in modifying digestive transit time.

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