Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia

2020 ◽  
Vol 379 ◽  
pp. 112338
Author(s):  
Taha Kelestemur ◽  
Mustafa C. Beker ◽  
Ahmet B. Caglayan ◽  
Berrak Caglayan ◽  
Serdar Altunay ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Neuronal Survival ◽  
Normobaric Oxygen ◽  
Axonal Plasticity ◽  
Oxygen Treatment ◽  
Hypoxia Ischemia

Oxygen treatment after perinatal hypoxia-ischemia reduces neuronal damage at short survival times, but worsens injury with long-term survival

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S444-S444 ◽  
Author(s):  
Kristin M Noppens ◽  
J Regino Perez-Polo ◽  
David K Rassin ◽  
Karin N Westlund ◽  
Roderic Fabian ◽  
...  
Keyword(s):  
Neuronal Damage ◽  
Perinatal Hypoxia ◽  
Survival Times ◽  
Term Survival ◽  
Long Term Survival ◽  
Short Survival ◽  
Oxygen Treatment ◽  
Hypoxia Ischemia

scholarly journals Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

2020 ◽  
Vol 6 (41) ◽  
pp. eabc5702
Author(s):  
Irene Sánchez-Morán ◽  
Cristina Rodríguez ◽  
Rebeca Lapresa ◽  
Jesús Agulla ◽  
Tomás Sobrino ◽  
...  
Keyword(s):  
Dna Repair ◽  
Functional Recovery ◽  
Nuclear Translocation ◽  
Neuronal Survival ◽  
Infarct Volume ◽  
Dna Double Strand Breaks ◽  
Single Nucleotide ◽  
Strand Breaks ◽  
Molecular Machinery

Failure of neurons to efficiently repair DNA double-strand breaks (DSBs) contributes to cerebral damage after stroke. However, the molecular machinery that regulates DNA repair in this neurological disorder is unknown. Here, we found that DSBs in oxygen/glucose-deprived (OGD) neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response. Mechanistically, OGD triggered a burst in reactive oxygen species that induced both DSBs and translocation of WRAP53 to the nucleus to promote DNA repair, a pathway that was confirmed in an in vivo mouse model of stroke. Noticeably, nuclear translocation of WRAP53 occurred faster in OGD neurons expressing the Wrap53 human nonsynonymous single-nucleotide polymorphism (SNP) rs2287499 (c.202C>G). Patients carrying this SNP showed less infarct volume and better functional outcome after stroke. These results indicate that WRAP53 fosters DNA repair and neuronal survival to promote functional recovery after stroke.

scholarly journals Effect of normobaric oxygen treatment on oxidative stress and enzyme activities in guinea pig heart

2012 ◽  
Vol 31 (02) ◽  
pp. 179-184 ◽  
Author(s):  
Zuzana Tatarkova ◽  
Ivan Engler ◽  
Andrea Calkovska ◽  
Daniela Mokra ◽  
Anna Drgova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Normobaric Oxygen ◽  
Oxygen Treatment

scholarly journals EEG sharp waves are a biomarker of striatal neuronal survival after hypoxia-ischemia in preterm fetal sheep

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hamid Abbasi ◽  
Paul P. Drury ◽  
Christopher A. Lear ◽  
Alistair J. Gunn ◽  
Joanne O. Davidson ◽  
...  
Keyword(s):  
Neuronal Survival ◽  
Fetal Sheep ◽  
Sharp Waves ◽  
Hypoxia Ischemia
Sign in / Sign up

Export Citation Format

Share Document