Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction

2008 ◽  
Vol 369 (1) ◽  
pp. 213-219 ◽  
Author(s):  
Hong Zhou ◽  
Takeshi Nakamura ◽  
Nagisa Matsumoto ◽  
Chihiro Hisatsune ◽  
Akihiro Mizutani ◽  
...  
Minerals ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 489 ◽  
Author(s):  
Alexandre Cugerone ◽  
Emilien Oliot ◽  
Alain Chauvet ◽  
Jordi Gavaldà Bordes ◽  
Angèle Laurent ◽  
...  

Pb-Zn deposits and specifically Sedimentary-Exhalative (SEDEX) deposits are frequently found in deformed and/or metamorphosed geological terranes. Ore bodies structure is generally difficult to observe and its relationships to the regional structural framework is often lacking. In the Pyrenean Axial Zone (PAZ), the main Pb-Zn mineralizations are commonly considered as Ordovician SEDEX deposits in the literature. New structural field analyzes focusing on the relations between mineralization and regional structures allowed us to classify these Pb-Zn mineralizations into three types: (I) Type 1 corresponds to minor disseminated mineralization, probably syngenetic and from an exhalative source. (II) Type 2a is a stratabound mineralization, epigenetic and synchronous to the Variscan D1 regional deformation event and (III) Type 2b is a vein mineralization, epigenetic and synchronous to the late Variscan D2 regional deformation event. Structural control appears to be a key parameter in concentrating Pb-Zn in the PAZ, as mineralizations occur associated to fold hinges, cleavage, and/or faults. Here we show that the main exploited type 2a and type 2b Pb-Zn mineralizations are intimately controlled by Variscan tectonics. This study demonstrates the predominant role of structural study for unraveling the formation of Pb-Zn deposits especially in deformed/metamorphosed terranes.


2011 ◽  
Vol 1808 (3) ◽  
pp. 745-751 ◽  
Author(s):  
L. Jones ◽  
L. Ma ◽  
J. Castro ◽  
T. Litjens ◽  
G.J. Barritt ◽  
...  
Keyword(s):  

2020 ◽  
Author(s):  
Dawn S. Lin ◽  
Luyi Tian ◽  
Sara Tomei ◽  
Daniela Amann-Zalcenstein ◽  
Tracey M. Baldwin ◽  
...  

SummaryExtrinsic regulation of single haematopoietic stem and progenitor cell (HSPC) fate is crucial for immune cell development. Here, we examine the aetiology of Flt3 ligand (Flt3L)-mediated emergency development of type 1 conventional dendritic cells (cDC1s), which results in enhanced immunity against infections and cancer. Using cellular barcoding, we demonstrate a predominant role of enhanced clonal expansion and moderate contribution via recruitment of additional cDC1-generating HSPCs. The selective cDC1 expansion occurs primarily via multi-/oligo-potent clones, without compromising output to other lineages. To understand the molecular hallmarks early during a Flt3L response, we develop Divi-Seq to simultaneously profile cell division history, surface phenotype and transcriptional state of single HSPCs. We discover that Flt3L-responsive HSPCs maintain a proliferative ‘early progenitor’-like state, which leads to selective emergence of CD11c+cKit+ transitional precursors with high cellular output to cDC1s. These findings inform the mechanistic action of Flt3L in natural immunity and immunotherapy at a clonal level.


2001 ◽  
Vol 121 (1-2) ◽  
pp. 120-125 ◽  
Author(s):  
B Greve ◽  
C.G.M Magnusson ◽  
A Melms ◽  
R Weissert

2015 ◽  
Vol 146 ◽  
pp. e42-e43
Author(s):  
Koji Mizuno ◽  
Kazuhiro Kurokawa ◽  
Tsutomu Suzuki ◽  
Seitaro Ohkuma
Keyword(s):  

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  

2013 ◽  
Author(s):  
P. Osborn ◽  
C. A. Berg ◽  
A. E. Hughes ◽  
P. Pham ◽  
D. J. Wiebe

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  

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