Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell

2009 ◽  
Vol 388 (4) ◽  
pp. 648-653 ◽  
Author(s):  
Akiko Eda ◽  
Yoshiko Tamura ◽  
Mariko Yoshida ◽  
Hirohiko Hohjoh
Keyword(s):  
Gene Regulation ◽  
Neuronal Differentiation ◽  
Carcinoma Cell ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cell

Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes

1994 ◽  
Vol 20 (5) ◽  
pp. 361-370 ◽  
Author(s):  
Charles E. Ogburn ◽  
Mitchell S. Turker ◽  
Terrance J. Kavanagh ◽  
Christine M. Disteche ◽  
Annette C. Smith ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Embryonic Carcinoma ◽  
Carcinoma Cell Lines ◽  
Embryonic Carcinoma Cell

scholarly journals Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2

2019 ◽  
Vol 20 (9) ◽  
pp. 2071 ◽  
Author(s):  
Mengying Yu ◽  
Lei Zhang ◽  
Yingxiang Liu ◽  
Defu Liu ◽  
Zekun Guo
Keyword(s):  
Retinoic Acid ◽  
Cell Differentiation ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Embryonic Carcinoma ◽  
Extracellular Signal ◽  
Embryonic Carcinoma Cells ◽  
Embryonic Carcinoma Cell ◽  
Mediate Cell

Retinoic acid (RA) plays a key role in pluripotent cell differentiation. In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Here, we show that miR-485 is a positive regulator that targets α/β-hydrolase domain-containing protein 2 (Abhd2), which can result in Erk1/2 phosphorylation and triggers differentiation. RA up-regulates miR-485 and concurrently down-regulates Abhd2. We verified that Abhd2 is targeted by miR-485 and they both can influence the phosphorylation of Erk1/2. In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.

DMRT-1 expression during NEC8 human embryonic carcinoma cell differentiation

2006 ◽  
Vol 97 (4) ◽  
pp. 277-282 ◽  
Author(s):  
Hitoshi Koji ◽  
Akira Yamada ◽  
Toshihiko Nagasawa ◽  
Shinobu Gamou
Keyword(s):  
Cell Differentiation ◽  
Carcinoma Cell ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cell ◽  
Human Embryonic Carcinoma Cell
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