scholarly journals Tenofovir treatment of primary osteoblasts alters gene expression profiles: Implications for bone mineral density loss

2010 ◽  
Vol 394 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Iwen F. Grigsby ◽  
Lan Pham ◽  
Louis M. Mansky ◽  
Raj Gopalakrishnan ◽  
Ann E. Carlson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Primary Osteoblasts

scholarly journals Network-Based Meta-Analyses of Associations of Multiple Gene Expression Profiles with Bone Mineral Density Variations in Women

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147475 ◽  
Author(s):  
Hao He ◽  
Shaolong Cao ◽  
Tianhua Niu ◽  
Yu Zhou ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Mineral Density ◽  
Multiple Gene ◽  
Meta Analyses

scholarly journals Identification of a key gene module associated with glucocorticoid- induced derangement in bone mineral density in patients with asthma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Suh-Young Lee ◽  
Ha-Kyeong Won ◽  
Byung-Keun Kim ◽  
Sae-Hoon Kim ◽  
Yoon-Seok Chang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Peripheral Blood ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Z Score ◽  
Gene Module ◽  
Mineral Density ◽  
Gene Modules

AbstractDerangement in bone mineral density (BMD) caused by glucocorticoid is well-known. The present study aimed to find key biological pathways associated with low BMD after glucocorticoid treatment in asthmatics using gene expression profiles of peripheral blood cells. We utilized immortalized B cells (IBCs) from 32 childhood asthmatics after multiple oral glucocorticoid bursts and peripheral blood mononuclear cells (PBMCs) from 17 adult asthmatics after a long-term use of oral glucocorticoid. We searched co-expressed gene modules significantly related with the BMD Z score in childhood asthmatics and tested if these gene modules were preserved and significantly associated with the BMD Z score in adult asthmatics as well. We identified a gene module composed of 199 genes significantly associated with low BMD in both childhood and adult asthmatics. The structure of this module was preserved across gene expression profiles. We found that the cellular metabolic pathway was significantly enriched in this module. Among 18 hub genes in this module, we postulated that 2 genes, CREBBP and EP300, contributed to low BMD following a literature review. A novel biologic pathway identified in this study highlighted a gene module and several genes as playing possible roles in the pathogenesis of glucocorticoid- induced derangement in BMD.

Genetic determinants of bone mineral density loss in aromatase inhibitors treatment in the B-ABLE Cohort

2014 ◽  
Author(s):  
Maria Rodriguez-Sanz ◽  
Natalia Garcia-Giralt ◽  
Pliego Elisa Torres-del ◽  
Daniel Prieto-Alhambra ◽  
Sonia Servitja ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Aromatase Inhibitors ◽  
Genetic Determinants ◽  
Mineral Density ◽  
Bone Mineral Density Loss

scholarly journals Bone mineral density loss in patients with cirrhosis

2018 ◽  
Vol 24 (6) ◽  
pp. 342 ◽  
Author(s):  
Fahad Alsohaibani ◽  
IbrahimN Muhsen ◽  
Omar AlFreihi ◽  
Faisal Abaalkhail ◽  
Abdullah AlKhenizan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Bone Mineral Density Loss

Bone Mineral Density Loss After Combat-Related Lower Extremity Amputation

2014 ◽  
Vol 28 (4) ◽  
pp. 238-244 ◽  
Author(s):  
James H. Flint ◽  
Alana M. Wade ◽  
Derek J. Stocker ◽  
Paul F. Pasquina ◽  
Robin S. Howard ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lower Extremity ◽  
Bone Mineral ◽  
Lower Extremity Amputation ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Extremity Amputation
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