Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice

2018 ◽  
Vol 507 (1-4) ◽  
pp. 476-483 ◽  
Author(s):  
Yusuke Ueba ◽  
Takaaki Aratake ◽  
Ken-ichi Onodera ◽  
Youichirou Higashi ◽  
Tomoya Hamada ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Spatial Memory ◽  
Memory Impairment ◽  
Short Term ◽  
M1 Phenotype

scholarly journals Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248689
Author(s):  
Il-Gyu Ko ◽  
Jun-Jang Jin ◽  
Lakkyong Hwang ◽  
Sang-Hoon Kim ◽  
Chang-Ju Kim ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Inflammatory Cytokines ◽  
Memory Impairment ◽  
Carotid Arteries ◽  
Short Term Memory ◽  
Mapk Signaling ◽  
Short Term ◽  
The Common ◽  
Common Carotid Arteries ◽  
Pro Inflammatory Cytokines

Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels, and cerebral ischemia activates mitogen-activated protein kinase (MAPK) and induces secretion of pro-inflammatory cytokines. Adenosine A2A receptor agonist, polydeoxyribonucleotide (PDRN), suppresses the secretion of pro-inflammatory cytokines and exhibits anti-inflammatory effect. In the current study, the therapeutic effect of PDRN on cerebral ischemia was evaluated using gerbils. For the induction of cerebral ischemia, the common carotid arteries were exposed, and then aneurysm clips were used to occlude the common carotid arteries bilaterally for 7 minutes. In the PDRN-treated groups, the gerbils were injected intraperitoneally with 0.3 mL of saline containing 8 mg/kg PDRN, per a day for 7 days following cerebral ischemia induction. In order to confirm the participation of the adenosine A2A receptor in the effects mediated by PDRN, 8 mg/kg 7-dimethyl-1-propargylxanthine (DMPX), adenosine A2A receptor antagonist, was treated with PDRN. In the current study, induction of ischemia enhanced the levels of pro-inflammatory cytokines and increased phosphorylation of MAPK signaling factors in the hippocampus and basolateral amygdala. However, treatment with PDRN ameliorated short-term memory impairment by suppressing the production of pro-inflammatory cytokines and inactivation of MAPK signaling factors in cerebral ischemia. Furthermore, PDRN treatment enhanced the concentration of cyclic adenosine-3,5’-monophosphate (cAMP) as well as phosphorylation of cAMP response element-binding protein (p-CREB). Co-treatment of DMPX and PDRN attenuated the therapeutic effect of PDRN on cerebral ischemia. Based on these findings, PDRN may be developed as the primary treatment in cerebral ischemia.

scholarly journals The effects of Ninjinyoeto on spatial memory impairment in a rat model with cerebral ischemia and β-amyloid injection

2021 ◽  
Vol 94 (0) ◽  
pp. 3-Y-F1-2
Author(s):  
Masaki Nagao ◽  
Akinobu Hatae ◽  
Kazuma Mine ◽  
Soichiro Tsutsumi ◽  
Marika Hiarata ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Spatial Memory ◽  
Rat Model ◽  
Memory Impairment ◽  
Β Amyloid

scholarly journals Aqueous extract of Cordyceps alleviates cerebral ischemia-induced short-term memory impairment in gerbils

2016 ◽  
Vol 12 (2) ◽  
pp. 69-78 ◽  
Author(s):  
Sang-Hak Lee ◽  
Il-Gyu Ko ◽  
Sung-Eun Kim ◽  
Lakkyong Hwang ◽  
Jun-Jang Jin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Aqueous Extract ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory
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