Omega-3 effects on electrocorticographic patterns of adult Wistar rats exposed to ionizing radiation

The purpose of this study was to map the common deletion (CD) area in mtDNA and investigate the levels of this deletion in irradiated heart. The assays were developed in male Wistar rats that were irradiated with three different single doses (5, 10 or 15 Gy) delivered directly to the heart and the analyses were performed at various times post-irradiation (3, 15 or 120 days). The CDs area were sequenced and the CD quantified by real-time PCR. Our study demonstrated that the CD levels progressively decreased from the 3rduntil the 15th day after irradiation, and then increased thereafter. Additionally, it was observed that the levels of CD are modulated differently according to the different categories of doses (moderate and high). This study demonstrated an immediate response to ionizing radiation, measured by the presence of mutations in the CD area and a decrease in the CD levels.

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Effect of Irradiation and Gentamycin on the Course of Experimental Peritonitis

Prehospital and Disaster Medicine ◽

10.1017/s1049023x0004440x ◽

1985 ◽

Vol 1 (S1) ◽

pp. 186-188

Author(s):

T. Orlowski ◽

S. Chabielski ◽

A. Badowski ◽

Z. Dumanski

Keyword(s):

Surgical Treatment ◽

Ionizing Radiation ◽

Wistar Rats ◽

Radiation Sickness ◽

Simultaneous Action ◽

Diffuse Peritonitis ◽

Abdominal Organs ◽

Male Wistar Rats ◽

Group 2 ◽

Group 1

The pathology of mixed injuries resulting from simultaneous action of several damaging factors on the organism is still insufficiently known. Peritonitis is the most frequent complication of injuries to the abdominal organs. Co-existence of peritonitis with radiation sickness impairs considerably the results of therapeutic management and prognosis. Surgical treatment is indicated in the latent period of radiation sickness or only in the period of recovery. In the case of diffuse peritonitis, the time of performing the operation is of essential importance for the prognosis. Thepurposeof the reportedinvestigationswas the study of the effect of ionizing radiation before exposure of the organism on the course of diffuse peritonitis and a trial of prolonging with an antibiotic the preliminary stage of the disease in which surgical treatment is effective. Investigations were carried out on 160 male Wistar rats weighing 250g on the average, divided into five groups. Group 1 served as control. In Group 2, the rats were only exposed to radiation.

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Omega-3 fatty acids moderate oxidative and proinflammatory events in experimental hepatotoxicity in Wistar rats: comparison with livolin

Synergy ◽

10.1016/j.synres.2018.08.001 ◽

2018 ◽

Vol 7 ◽

pp. 17-24 ◽

Cited By ~ 5

Author(s):

Luqman Aribidesi Olayaki ◽

Wale Johnson Adeyemi ◽

Joseph Sunday Yinusa ◽

Grace Amarachi Adedayo

Keyword(s):

Fatty Acids ◽

Wistar Rats ◽

Omega 3 Fatty Acids ◽

Omega 3

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Effects of ionizing radiation on bone neoformation: histometric study in Wistar rats tibiae

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502011000600012 ◽

2011 ◽

Vol 26 (6) ◽

pp. 475-480 ◽

Cited By ~ 6

Author(s):

Susette Cavicchioli Lucatto ◽

Arnaldo Guilherme ◽

Luciano Lauria Dib ◽

Helena Regina Comodo Segreto ◽

Maria Tereza de Seixas Alves ◽

...

Keyword(s):

Radiation Dose ◽

Ionizing Radiation ◽

Radiation Effects ◽

Wistar Rats ◽

Bone Cells ◽

Secondary Radiation ◽

Male Wistar Rats ◽

Histological Processing ◽

The Right ◽

Single Dosage

PURPOSE: Comparing the ionizing radiation effects on bone neoformation of rats tibiae previously submitted to radiotherapy with a single dosage of 30Gy with the contralateral tibiae that have received secondary radiation. METHODS: In thirty male Wistar rats, 30 days before surgical procedure when round defects would be created on the bone, the right tibia was irradiated with 30Gy and the left tibia received a calculated secondary radiation dose of 7Gy. Sacrifices were performed after 4, 7, 14, 21, 56 and 84 postoperative days and both tibiae were removed for histological processing. RESULTS: The left tibiae that received the dose of 7Gy has shown more bone neoformation from 14th postoperative days, giving evidences of less damage to cellular population responsible by bone neoformation. On the other hand, the dose of 30Gyon right tibiae did not exhibit significant differences among the periods, suggesting damage of long-lasting or even permanent duration. CONCLUSION: Tibiae submitted to radiation dose of 30Gy have shown more damage to bone cells than tibiae that received secondary radiation dose of 7Gy, especially observed on 14th, 56th and 84th postoperative days.

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Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats

Revista do Colégio Brasileiro de Cirurgiões ◽

10.1590/0100-69912015006008 ◽

2015 ◽

Vol 42 (6) ◽

pp. 393-397 ◽

Cited By ~ 4

Author(s):

Rosilda Mendes da Silva ◽

Osvaldo Malafaia ◽

Orlando Jorge Martins Torres ◽

Nicolau Gregori Czeczko ◽

Carlos Hespanha Marinho Junior ◽

...

Keyword(s):

Fatty Acids ◽

Liver Regeneration ◽

Wistar Rats ◽

Statistical Difference ◽

Histological Study ◽

Liver Weight ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Serum Aspartate Aminotransferase ◽

Significant Interference

Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.

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