STRENGTH OF SHIPS’ GRILLAGES UNDER LATERAL LOAD AND IN-PLANE COMPRESSION

The paper deals with strength of a grillage loaded by lateral load and in-plane compression load (in one direction). It consists of a system of prismatic girders crossing under 90°. The compression load is taken by the longitudinal girders that are elastically fixed on rigid supports. The system of aggregated differential equations is derived for solution of the problem using the Lagrange method. It allows for replacement of the system of aggregated differential equations by a system of independent differential equations. These equations for the case of simultaneous action of lateral and longitudinal compression load have the form of differential equations for bending of prismatic girders laying on elastic foundation and loaded with lateral and longitudinal compression forces. When only lateral load exists, the form of these equations coincides with the form of differential equations for bending of girders laying on elastic foundation and loaded with lateral load alone. When only longitudinal compression load exists, the form of these equations coincides with the form of differential equations for buckling of girders laying on elastic foundation. Solutions are given for bending of a grillage (the first two problems). Formulas are derived for calculation of the parameters of longitudinal girders’ bending when girders’ end sections are elastically fixed. Also, formulas are derived for calculation of the reaction forces at cross-points of transverse and longitudinal girders. When only longitudinal compression load exists (third problem), a solution is given for the connection between the coefficient of elastic foundation’s rigidity and the Euler force. Results obtained by using the proposed method are compared with FEA simulations.

DEVELOPMENT OF A METHOD FOR CONSTRUCTING AND ASSESSING THE RELIABILITY OF HYPOTHESES ABOUT THE INTERRELATION OF A COMBINATION OF CYTOKINES AND OPHTHALMIC PREPARATIONS USING AN INTELLIGENT INFORMATION SYSTEM

В работе рассмотрено сравнение экспериментальных распределений количества клеток для определения цитологического и иммунологического эффекта, оказываемого одновременным воздействием офтальмологических препаратов Броксинак® и Офтальмоферон® на клетки с конъюнктивы больного человека, направленное на совершенствование методики оценки комбинаций офтальмологических лекарственных средств in vitro. Доклинические исследования дают возможность определить эффективность применения лекарственных средств, возможные противопоказания и побочные эффекты, чтобы в дальнейшем определиться с объемом клинических испытаний и самой возможностью их проведения. В последнее время в различных областях медицины применяют счетчики клеток. Счетчики определяют не только количество клеток в образце, но и их размеры и объем, что позволяет сделать предположение о виде клеточной структуры. Подобные приборы позволяют автоматизировать подсчет клеток, определение их размеров и объема, что исключает субъективный фактор и возможность получения ошибочных данных, а также упрощает процедуру и позволяет получить результаты в короткий срок. На основе использования методов индуктивного вывода предложена методика построения гипотез о взаимосвязи комбинации цитокинов с пролиферативной активностью клеток. Методика учитывает синергическое взаимодействие цитокинов и использует последовательное построение логических формул для отбора групп цитокинов, статистический анализ таблиц сопряженности и логическую интеграцию полученных оценок. Реализация предложенной методики в рамках ИС позволит существенно ускорить научные исследования в этой области. Приведена итоговая методика построения гипотез о взаимосвязи комбинации цитокинов с биологической активностью клеток The paper considers a comparison of experimental distributions of the number of cells to determine the cytological and immunological effect of the simultaneous action of ophthalmic drugs Broxinac® and Oftalmoferon® on cells from the conjunctiva of a sick person, aimed at improving the methodology for assessing combinations of ophthalmic drugs in vitro. Preclinical studies make it possible to determine the effectiveness of the use of drugs, possible contraindications and side effects, in order to further determine the volume of clinical trials and the very possibility of their conduct. Recently, cell counters have been used in various fields of medicine. Counters determine not only the number of cells in the sample, but also their size and volume, which allows us to make an assumption about the type of cell structure. Such devices allow automating the counting of cells, determining their size and volume, which eliminates the subjective factor and the possibility of obtaining erroneous data, and also simplifies the procedure and allows you to get results in a short time. Based on the use of inductive inference methods, a method is proposed for constructing hypotheses about the relationship between the combination of cytokines and the proliferative activity of cells. The method takes into account the synergistic interaction of cytokines and uses the sequential construction of logical formulas for the selection of groups of cytokines, statistical analysis of contingency tables and logical integration of the estimates obtained. The implementation of the proposed methodology within the Information System will significantly accelerate research in this area. The final technique for constructing hypotheses about the relationship of the combination of cytokines with the biological activity of cells is presented

Abundant Allelochemicals and the Inhibitory Mechanism of the Phenolic Acids in Water Dropwort for the Control of Microcystis aeruginosa Blooms

In recent years, with the frequent global occurrence of harmful algal blooms, the use of plant allelopathy to control algal blooms has attracted special and wide attention. This study validates the possibility of turning water dropwort into a biological resource to inhibit the growth of harmful Microcystis aeruginosa blooms via allelopathy. The results revealed that there were 33 types of allelopathic compounds in the water dropwort culture water, of which 15 were phenolic acids. Regarding water dropwort itself, 18 phenolic acids were discovered in all the organs of water dropwort via a targeted metabolomics analysis; they were found to be mainly synthesized in the leaves and then transported to the roots and then ultimately released into culture water where they inhibited M. aeruginosa growth. Next, three types of phenolic acids synthesized in water dropwort, i.e., benzoic, salicylic, and ferulic acids, were selected to clarify their inhibitory effects on the growth of M. aeruginosa and their mechanism(s) of action. It was found that the inhibitory effect of phenolic acids on the growth of M. aeruginosa increased with the increase of the exposure concentration, although the algae cells were more sensitive to benzoic acid than to salicylic and ferulic acids. Further study indicated that the inhibitory effects of the three phenolic acids on the growth of M. aeruginosa were largely due to the simultaneous action of reducing the number of cells, damaging the integrity of the cell membrane, inhibiting chlorophyll a (Chl-a) synthesis, decreasing the values of F0 and Fv/Fm, and increasing the activity of the antioxidant enzymes (SOD, POD, and CAT) of M. aeruginosa. Thus, the results of this study indicate that both culture water including the rich allelochemicals in water dropwort and biological algae inhibitors made from water dropwort could be used to control the growth of noxious algae in the future.

Synergistic Effect of Ultrasound Cavitation and Gas in the Water Disinfection

The paper considers water purification processes from Bacillus bacteria type under the conditions of gases bubbling only (argon, helium, oxygen, and carbon dioxide), cavitation and combined action of gas and cavitation. The synergistic effect was found under conditions of simultaneous action of gas and cavitation (kd(gas/US ) >kd(gas) + kd(US) almost double) and it was shown that kd(gas/US) >kd(gas) by almost an order of magnitude. Relative series of effective destruction of microbial cells was established: Ar/US > О2/US >Не/US > СО2/US. Destruction degree of the cells reaches 70 %at the short-term Ar/US exposure (~8 min), which is 7 times more active than cavitation action and 13.5 times more than bubbling of Aralone.

Substantiation of the Density of the Soil Formed by a Ridge Drill Roller

A method is presented for determining the density of soil in the ridge from the simultaneous action of spherical disks and a conical roller wheel. Heuristic and technical analysis of the process of forming soil ridges by rollers made it possible to conclude with a 90 % reliability that the main factorsб which significantly affect the quality of soil ridge formation, are the angle of attack of spherical discs (α = 10°), the speed of the roller (vс = 5.4 km / h) and the compression force of its spring (Fspr. = 180 N).

A Review On Public Health through Rural Health Mission: Pharmacist Roles and Responsibility

For many years, the Government of India has worked hard to offer health services to people all around the country, and it remains dedicated to doing so. It has formed numerous programmes to achieve the goal of “Health for All.” As a result, in 2005, The Hon’ble Prime Minister formed the The National Rural Health Mission will provide the countries’ network with well-being administrations. The National Rural Health Mission, which went into effect in April 2005, is considered the backbone of the rural sector. They have been instilled with the belief that, as a result of their efforts, something special has appeared to assist the country dwellers in re-establishing their well-being. The National Rural Health Mission (NRHM) aims to provide rural populations, especially disadvantaged groups, with comprehensive, low-cost, and high-quality health care. Material & Method: We reviewed all of the articles published on PubMed, Scopus, BMJ, Google scholar, Nature, Web of science that were focusing on, National rural health mission services, to achieving universal health coverage (UHC). Conclusion: This study compiles a list of all social need interventions that have been described in the literature to date. National health systems around the world are reforming to meet health goals, with a focus on cost containment, universal coverage, equity in access and quality, and resource efficiency and effectiveness. The primary purpose of the mission is to establish a fully operational, community-owned, decentralised health-care delivery system with cross-sectoral integration at all levels, enabling for simultaneous action on a wide variety of health determinants such as poverty and social equity.

Study of Concrete under Combined Action of Aggressive Environment and Long-Term Loading

A significant part of reinforced concrete structures is subjected to intensive environmental impact during operation. This can cause local destruction and failure of buildings if obligatory measures are not taken to protect them from corrosion. This is especially true for industrial buildings, where the environment could be contaminated with aggressive products or waste. An important issue is the development of methods for calculating the load-bearing capacity and serviceability of reinforced concrete structures with corrosion damage. The main reason for this is the necessity to determine the durability and reliability of buildings and structures and the estimation of their safe operation time. As corrosion damages of concrete are a critical issue, more detailed experimental studies are needed. This paper presents experimental studies of concrete prisms under the simultaneous action of an aggressive environment and a constant level of compressive force. In total, 32 prisms under different loading conditions and in different aggressive medium were tested. Samples were divided in series, for which different load levels were chosen (0.25fck, 0.35fck, 0.45fck). Additionally, control samples in the air and immersed in water were tested. During the experiment, different parameters were monitored and recorded: decrease of cross-sectional size, the temperature and environmental humidity. Results of the study showed that destruction occurred due to the presence of corrosion damages of concrete and a reduction of the cross-sectional area. The stresses in the concrete at the destruction stage were less than the value of the prism strength by 10–12%. It was established that along the contour of the section, there is a partially degraded layer of concrete of 1.5–3.7 mm thickness, with corrosion microcracks and corrosion products. Additionally, experimental and theoretical diagrams of concrete with corrosion damages were obtained and compared. The ultimate deformations of concrete with corrosion damage, which correspond to the prismatic strength of concrete, in comparison with undamaged concrete were lower by 11–18%. Therefore, the concrete strength is decreased during exploitation under loading in an aggressive environment, which needs to be taken into account during calculations.

Humic Substances in Combination With Plant Growth-Promoting Bacteria as an Alternative for Sustainable Agriculture

Plant growth-promoting bacteria (PGPB) and humic substances (HSs) are promising options for reducing the use of pesticides and mineral fertilizers. Although many studies have shown the effects of PGPB and HSs separately, little information is available on plant responses to the combined application of these biostimulants despite the great potential for the simultaneous action of these biological inputs. Thus, the objective of this review is to present an overview of scientific studies that addressed the application of PGPB and HSs to different crops. First, we discuss the effect of these biostimulants on biological nitrogen fixation, the various effects of the inoculation of beneficial bacteria combined with the application of HSs on promoting the growth of nonleguminous plants and how this combination can increase bacterial colonization of plant hosts. We also address the effect of PGPB and HSs on plant responses to abiotic stresses, in addition to discussing the role of HSs in protecting plants against pathogens. There is a lack of studies that address the role of PGPB + HSs in biocontrol. Understanding the factors involved in the promotion of plant growth through the application of PGPB and HSs can assist in the development of efficient biostimulants for agricultural management. This approach has the potential to accelerate the transition from conventional cultivation to sustainable agrosystems.

The Influence of Temperature on Degradation of Oil and Gas Tubing Made of L80-1 Steel

Corrosion in the oil and gas industry is very common due to the simultaneous action of a chemically active environment, temperature, and other non-chemical factors, for example, mechanical erosion by friction, and for these reasons corrosion is a very complex process. Corrosion at higher temperatures is an important aspect when extracting natural gas from a field with high temperatures (120 °C in the Lubiatow deposit and 180 °C in the gas well in Kutno). Water in the reservoir is often in the form of steam, with a pressure of about 25 MPa; as a result of its extraction, it cools down, which causes condensation. Condensed water in contact with the acid components of the gas causes corrosion, especially in the presence of aggressive gases, such as CO2 and H2S. Therefore, the aim of the work was to conduct research on the influence of water condensation, as a result of temperature changes in gasses containing CO2 and H2S on the corrosion of L80-1 steel at the junction of extraction pipes with casing pipes. The tests are carried out at temperatures of 65–95 °C, under a pressure of 7.5 MPa, so in quite aggressive conditions. The duration of the studies was 720 h (within a month). The results of the research allowed an answer to be provided for the question of what influence temperature, gas components, and pressure have on the corrosion of the well construction material. Moreover, the results clearly showed the selection of the material for the well, in order to prevent corrosion in aggressive environments.