Focal adhesion kinase dependent activation of the PI3 kinase pathway by the functional soluble form of neurotensin receptor-3 in HT29 cells

2013 ◽  
Vol 45 (5) ◽  
pp. 952-959 ◽  
Author(s):  
Fabienne Massa ◽  
Christelle Devader ◽  
Sophie Béraud-Dufour ◽  
Frédéric Brau ◽  
Thierry Coppola ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Pi3 Kinase ◽  
Soluble Form ◽  
Neurotensin Receptor ◽  
Ht29 Cells ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation

2016 ◽  
Vol 17 (11) ◽  
pp. 1860 ◽  
Author(s):  
Sophie Béraud-Dufour ◽  
Christelle Devader ◽  
Fabienne Massa ◽  
Morgane Roulot ◽  
Thierry Coppola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Colorectal Cancer Cell ◽  
Soluble Form ◽  
Cell Dissociation ◽  
Neurotensin Receptor

Integration of stimulatory and inhibitory signals in pituitary tumor cells through the PI3 kinase pathway

2006 ◽  
Vol 114 (08) ◽  
Author(s):  
T Colaco ◽  
C Onofri ◽  
M Theodoropoulou ◽  
M Kowarik ◽  
GK Stalla ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Pituitary Tumor ◽  
Pi3 Kinase ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

2012 ◽  
Vol 41 (5) ◽  
pp. 1635-1642 ◽  
Author(s):  
WEN G. JIANG ◽  
LIN YE ◽  
KE JI ◽  
NATASHA FREWER ◽  
JIAFU JI ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Inhibitory Effects ◽  
Kinase Pathway

scholarly journals c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3′-Kinase Pathway

Blood ◽  
1998 ◽  
Vol 91 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Hiroo Ueno ◽  
Ko Sasaki ◽  
Hiroaki Honda ◽  
Tetsuya Nakamoto ◽  
Tetsuya Yamagata ◽  
...  
Keyword(s):  
Specific Inhibitor ◽  
Pi3 Kinase ◽  
Interleukin 4 ◽  
Phosphatidylinositol 3 Kinase ◽  
Proliferation And Differentiation ◽  
Interleukin 4 Receptor ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway ◽  
Phosphatidylinositol 3 ◽  
Survival Signals

Interleukin-4 (IL-4) is a cytokine that induces both proliferation and differentiation and suppresses apoptosis of B cells. Although IL-4 has been shown to activate the phosphatidylinositol 3′ (PI3)-kinase pathway, the role of PI3 kinase in the IL-4 receptor (IL-4R) signaling remains unclear. In this study, we demonstrated that c-Cbl proto-oncogene product is inducibly phosphorylated on tyrosine residues and is associated with the p85 subunit of PI3-kinase by IL-4 stimulation. Overexpression of c-Cbl enhances the PI3-kinase activity and, at the same time, mitogenic activity and survival of cells in the presence of IL-4. However, these effects of c-Cbl were abolished by wortmannin, a specific inhibitor for the PI3 kinase pathway, or by a point mutation at tyrosine 731 of c-Cbl, which is a major binding site for p85. These results indicate that c-Cbl plays a role in linking IL-4R with the PI3 kinase pathway and thus enhancing the mitogenic and survival signals.

scholarly journals PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Rajani Kanteti ◽  
Jacob J. Riehm ◽  
Immanuel Dhanasingh ◽  
Frances E. Lennon ◽  
Tamara Mirzapoiazova ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pi3 Kinase ◽  
Pleural Mesothelioma ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Zahid Nawaz ◽  
Vikas Patil ◽  
Yashna Paul ◽  
Alangar S. Hegde ◽  
Arimappamagan Arivazhagan ◽  
...  
Keyword(s):  
Pi3 Kinase ◽  
Tumour Suppressor ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

Tonic support of contraction involving the PI3 kinase pathway in ventricular myocytes from failing human heart

2008 ◽  
Vol 44 (4) ◽  
pp. 752-753
Author(s):  
Edwin A. Garcia ◽  
Gaelle Kikonda Kanda ◽  
Alexander Lyon ◽  
Clare E. Gallon ◽  
Andrew E. Messer ◽  
...  
Keyword(s):  
Human Heart ◽  
Ventricular Myocytes ◽  
Pi3 Kinase ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway
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