The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells

Biochimie ◽  
2012 ◽  
Vol 94 (8) ◽  
pp. 1754-1763 ◽  
Author(s):  
Youness Limami ◽  
Aline Pinon ◽  
David Yannick Leger ◽  
Emilie Pinault ◽  
Christiane Delage ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Prostate Cancer Cells ◽  
Cox 2 ◽  
Induced Apoptosis

Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGFβ

2018 ◽  
Vol 44 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Ozge Cevik ◽  
Fatma Aysun Turut ◽  
Hilal Acidereli ◽  
Sahin Yildirim
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cyclosporine A ◽  
Luciferase Reporter ◽  
Prostate Cancer Cells ◽  
Luciferase Reporter Plasmid ◽  
Determine Role ◽  
Cox 2 ◽  
Induced Apoptosis ◽  
Relationship Of

Abstract Background Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. However, the molecular effects of CsA is not fully understood in prostate cancer. In this research, we sought to determine role and mechanism of CsA in prostate cancer. Materials and methods PC3 and DU145 cells were treated with CsA time (12, 24, 48 h) and dose dependent (2.5, 10, 25 μM) and cell survival, migration, colony formation, expression of apoptosis related proteins/genes using MTT assay, scratch assay, Western blotting/qPCR. At the same time, cells treated with CsA to test on the effects of COX-2 promoter activity using luciferase reporter plasmid. Lastly, functional role in the CsA treatment prostate cancer cells were interrogated for relationship of TGFβ, Akt, caspases and COX-2. Results These study findings provided direct evidences that the CsA induced apoptosis and downregulated migration. Conclusions CsA downregulated Akt as well as COX-2 and upregulated TGFβ, resulting in the suppression of cell migration which was augmented a potential therapeutic of CsA in prostate cancer cells.

Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells

2013 ◽  
Vol 65 (5) ◽  
pp. 1366-1374 ◽  
Author(s):  
Ji-Hyuk Park ◽  
Hee-Young Kwon ◽  
Eun Jung Sohn ◽  
Kyung A. Kim ◽  
Bonglee Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis

The effects of aspirin on growth and COX-2 expression in prostate cancer cells

2016 ◽  
Vol 61 ◽  
pp. S41
Author(s):  
R. Wang ◽  
U.K. Shah ◽  
G. Jenkins ◽  
S. Doak
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Cox 2

Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis

The Prostate ◽  
2010 ◽  
Vol 71 (2) ◽  
pp. 111-124 ◽  
Author(s):  
Sandra Cuffe ◽  
Catherine M. Dowling ◽  
James Claffey ◽  
Clara Pampillón ◽  
Megan Hogan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Titanocene Dichloride ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis

Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells

2008 ◽  
Vol 314 (17) ◽  
pp. 3162-3174 ◽  
Author(s):  
N PAPADOPOULOU ◽  
I CHARALAMPOPOULOS ◽  
K ALEVIZOPOULOS ◽  
A GRAVANIS ◽  
C STOURNARAS
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Membrane Androgen Receptor
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