Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy

In the present work two different hydroxyapatite nanofilms (50 and 100 nm thick) have been successfully deposited on titanium implants that were previously laser macrostructured in order to assess the influence of the thickness of nanometric calcium phosphate coatings on the osseointegration. Cylindrical implants were tested in a sheep tibia model together with titanium alloy controls achieving very good osseointegration results. Laser macrostructured titanium alloy implants have shown improved bone regeneration when coated with nanometric films of carbonated HA. The pulsed laser deposited nanofilm has promoted bone in-growth deep into the laser ablated craters. There were no significant differences between the two coating thicknesses, neither when assessed with electron microscopy or classical optical methods. This result suggests that the 50 nm coating is as effective as the 100 nm one, therefore implying that the thickness limit for such a bioactive layer to stimulate bone growth may be even further below.

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In vivo Osteogenerating Properties of Calcium Phosphate Coatings on Ti-6Al-4V Titanium Alloy

Biomedical Engineering ◽

10.1007/s10527-017-9696-5 ◽

2017 ◽

Vol 51 (2) ◽

pp. 116-119 ◽

Cited By ~ 1

Author(s):

S. V. Gnedenkov ◽

S. L. Sinebryukhov ◽

A. V. Puz’ ◽

R. E. Kostiv

Keyword(s):

Titanium Alloy ◽

Calcium Phosphate ◽

Phosphate Coatings ◽

Calcium Phosphate Coatings

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Electrochemically Assisted Co-Precipitation of Electrically Conducting Polymer with Calcium Phosphate Coatings on Ti Alloys

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.336-338.1632 ◽

2007 ◽

Vol 336-338 ◽

pp. 1632-1634

Author(s):

Chen Ma ◽

Li Jie Qu ◽

Mu Qin Li ◽

Shi Qin Yang ◽

Jian Ping Wang

Keyword(s):

Calcium Phosphate ◽

Conducting Polymer ◽

Calcium Phosphate Coating ◽

Implant Fixation ◽

Electrically Conducting ◽

Ti Alloys ◽

Phosphate Coatings ◽

Structure Of Coatings ◽

Co Precipitation ◽

Calcium Phosphate Coatings

Electrically conducting polymer containing calcium phosphate coating (ppy/brushite) was made on the Ti-6Al-4V surface by means of electrochemically assisted co-precipitation. This study examined the effects of the electrically conducting polymer on electrochemically assisted co-precipitation of ppy/ brushite onto titanium alloys. Electrochemically assisted co-precipitation of ppy/ brushite coatings resulted in an increase in the thickness and adhesion of coatings compared to those of coatings of single calcium phosphate at the same deposition conditions. The surface morphology of coatings characterized by SEM showed that the morphology of ppy/ brushite was superior to that of brushite. XRD indicated that ppy did not change the phase of brushite. Thus, this electrochemically assisted co-precipitation technique provides an effective method of polypyrrole incorporation at physiological temperature, which can offer excellent thickness, adhesion and structure of coatings, with a potential for sustained release of therapeutic agents as required for metallic implant fixation.

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Formation of Solution-derived Hydroxyapatite Coatings on Titanium Alloy in the Presence of Magnetron-sputtered Alumina Bond Coats

The Open Biomedical Engineering Journal ◽

10.2174/1874120701509010075 ◽

2015 ◽

Vol 9 (1) ◽

pp. 75-82 ◽

Cited By ~ 6

Author(s):

Anna Zykova ◽

Vladimir Safonov ◽

Anna Yanovska ◽

Leonid Sukhodub ◽

Renata Rogovskaya ◽

...

Keyword(s):

Titanium Alloy ◽

Calcium Phosphate ◽

Ceramic Materials ◽

Tissue Response ◽

Hybrid Technique ◽

Bond Coats ◽

Ceramic Oxide ◽

Hydroxyapatite Coatings ◽

Phosphate Coatings ◽

Calcium Phosphate Coatings

Hydroxyapatite Ca10(PO4)6(OH)2(HAp) and calcium phosphate ceramic materials and coatings are widely used in medicine and dentistry because of their ability to enhance the tissue response to implant surfaces and promote bone ingrowth and osseoconduction processes. The deposition conditions have a great influence on the structure and biofunctionality of calcium phosphate coatings. Corrosion processes and poor adhesion to substrate material reduce the lifetime of implants with calcium phosphate coatings. The research has focused on the development of advanced methods to deposit double-layered ceramic oxide/calcium phosphate coatings by a hybrid technique of magnetron sputtering and thermal methods. The thermal method can promote the crystallization and the formation of HAp coatings on titanium alloy Ti6Al4V substrates at low temperature, based on the principle that the solubility of HAp in aqueous solutions decreases with increasing substrate temperature. By this method, hydroxyapatite directly coated the substrate without precipitation in the initial solution. Using a thermal substrate method, calcium phosphate coatings were prepared at substrate temperatures of 100-105oC. The coated metallic implant surfaces with ceramic bond coats and calcium phosphate layers combine the excellent mechanical properties of metals with the chemical stability of ceramic materials. The corrosion test results show that the ceramic oxide (alumina) coatings and the double-layered alumina-calcium phosphate coatings improve the corrosion resistance compared with uncoated Ti6Al4V and single-layered Ti6Al4V/calcium phosphate substrates. In addition, the double-layered alumina/hydroxyapatite coatings demonstrate the best biocompatibility duringin vitrotests.

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