The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts

Biomaterials ◽  
2005 ◽  
Vol 26 (36) ◽  
pp. 7579-7586 ◽  
Author(s):  
H. Zreiqat ◽  
Stella M. Valenzuela ◽  
Besim Ben Nissan ◽  
Richard Roest ◽  
Christine Knabe ◽  
...  
2005 ◽  
Vol 284-286 ◽  
pp. 541-544 ◽  
Author(s):  
Hala Zreiqat ◽  
R. Roest ◽  
Stella Valenzuela ◽  
Adriyan Milev ◽  
Besim Ben-Nissan

Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the noncemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC)behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein Shc and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.


2020 ◽  
Vol 31 (S20) ◽  
pp. 97-97
Author(s):  
Ji‐Won Jung ◽  
Jai‐Young Koak ◽  
Seong‐Joo Heo ◽  
Seong‐Kyun Kim ◽  
Myung‐Joo Kim

Nanoscale ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1893-1903
Author(s):  
Wei Li Ang ◽  
Jiri Sturala ◽  
Nikolas Antonatos ◽  
Zdeněk Sofer ◽  
Alessandra Bonanni

The surface ligands on chemically modified germanenes have strong influence on the intrinsic fluorescence, on the bio-conjugation ability and the bio-recognition efficiency of the material towards the detection of a specific analyte.


Langmuir ◽  
2020 ◽  
Vol 36 (45) ◽  
pp. 13415-13425 ◽  
Author(s):  
Daniel W. Müller ◽  
Anne Holtsch ◽  
Sarah Lößlein ◽  
Christoph Pauly ◽  
Christian Spengler ◽  
...  

2016 ◽  
Vol 116 (5) ◽  
pp. 797-802 ◽  
Author(s):  
Nuno Guilherme ◽  
Chandur Wadhwani ◽  
Cheng Zheng ◽  
Kwok-Hung Chung

Carbon ◽  
2021 ◽  
Vol 185 ◽  
pp. 252-263
Author(s):  
Marc Florent ◽  
Konrad Rotnicki ◽  
Natalia Przybylska ◽  
Małgorzata Sliwinska-Bartkowiak ◽  
Teresa J. Bandosz

2011 ◽  
Vol 43 (12) ◽  
pp. 1543-1548 ◽  
Author(s):  
J. N. Li ◽  
C. Z. Chen ◽  
B. B. Cui ◽  
T. Squartini

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