Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

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Fabrication of photosensitizer-polyethylene glycol-conjugated gold nanostars for simultaneous photothermal and photodynamic cancer therapy under near-infrared laser irradiation

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102892 ◽

2021 ◽

pp. 102892

Author(s):

Yasuhito Kondo ◽

Tatsuaki Tagami ◽

Tetsuya Ozeki

Keyword(s):

Polyethylene Glycol ◽

Cancer Therapy ◽

Laser Irradiation ◽

Near Infrared ◽

Infrared Laser ◽

Gold Nanostars ◽

Photodynamic Cancer Therapy ◽

Infrared Laser Irradiation

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Photothermal Effect of Superparamagnetic Fe3O4 Nanoparticles Irradiated by Near-Infrared Laser

Journal of Nanomaterials ◽

10.1155/2020/2832347 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Shawei Fu ◽

Yuchun Man ◽

Fuquan Jia

Keyword(s):

Cancer Treatment ◽

Power Density ◽

Infrared Absorption ◽

Fe3o4 Nanoparticles ◽

Near Infrared ◽

Infrared Laser ◽

Photothermal Effect ◽

Transduction Efficiency ◽

Large Power ◽

Fe3o4 Nps

Fe3O4 nanoparticles (NPs) have been widely used in biomedicine due to their unique magnetism, biocompatibility, and biodegradability. Magnetic hyperthermia of Fe3O4 NPs for cancer treatment has attracted more attention. However, it could interfere with magnetic field-sensitive devices of patients, such as pacemakers. Therefore, it is necessary to find a new method for clinical therapy. In this study, the superparamagnetic Fe3O4 NPs were fabricated. Visible-near-infrared absorption spectra indicated that the Fe3O4 NPs have near-infrared absorption. The influences of Fe3O4 NP concentrations, power density, and wavelength of near-infrared laser irradiation on the photothermal performance of Fe3O4 NPs were investigated. The results revealed that high concentrations, large power density, and short irradiation wavelength could improve the photothermal performance of Fe3O4 NPs. The temperature variation and the absorption intensity simultaneously determined the photothermal transduction efficiency of Fe3O4 NPs. The application of the photothermal performance of Fe3O4 NPs would provide a new opportunity for clinic cancer treatment.

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