Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer

355 Background: Pancreatic neck cancer is surrounded by common hepatic artery (CHA), gastroduodenal artery (GDA) and portal vein (PV), and easily invades nerve plexus around main arteries, such as CHA, celiac trunk, and superior mesenteric artery (SMA). Therefore, the resectablity of pancreatic neck cancer is low, and the biological behaviors have been unclear. In this study, we reviewed 59 resected pancreatic neck cancer cases to identify the prognostic factors. Methods: From 2000 to 2012, 305 patients with pancreatic cancer underwent surgical resection, and in 59 patients (19%) among them with pancreatic neck cancer, 49 patients underwent pancreatoduodenectomy, 5 subtotal pancreatectomy, 4 distal pancreatectomy with en-bloc celiac axis, and 1 total pancreatectomy. We defined borderline resectable pancreatic cancer as tumor abutted CHA, celiac trunk, or SMA, and classified radiographic types of PV invasion into A (normal), B (unilateral), C (bilateral), or D (complete obstruction) by CT imaging. We analyzed retrospectively clinicopathological characteristics and prognostic factors for pancreatic neck cancer. Results: Pancreatic neck cancer was smaller than other located pancreatic cancer (21.1±7.0 vs. 32.0±13.5 mm, P<0.01), and the rate of pathological PV invasion was higher in pancreatic neck cancer (36 vs. 20%, P=0.01). In patients with pancreatic neck cancer, pathological PV invasion was observed in 0% of type A (0/9), 14% of type B (3/22), 48% of type C (10/21), and 86% of type D (6/7), and 37 patients (63%) had lymph node metastasis. In 32 patients with borderline resectable pancreatic neck cancer, neoadjuvant chemo(radiation)therapy (NAC) reduced the R1 rates (P=0.04) Pathological PV invasion, tub2/3 and lymph node ratio >0.1 were independent poor prognostic factors for pancreatic neck cancer (P<0.01, P=0.03, and P=0.03, odds ratio; 7.1, 2.8, and 3.1, respectively). Conclusions: Pancreatic neck cancer often had PV invasion even if CT imaging showed unilateral abutment, indicating that combined PV resection may be necessary for R0 resection of pancreatic neck cancer with radiological PV abutment. NAC may improve R0 resection rates and postoperative survival for pancreatic neck cancer.

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MicroPET/CT imaging of patient-derived pancreatic cancer xenografts implanted subcutaneously or orthotopically in NOD-scid mice using 64Cu-NOTA-panitumumab F(ab')2 fragments

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2014.10.009 ◽

2015 ◽

Vol 42 (2) ◽

pp. 71-77 ◽

Cited By ~ 15

Author(s):

Amanda J. Boyle ◽

Ping-Jiang Cao ◽

David W. Hedley ◽

Sachdev S. Sidhu ◽

Mitchell A. Winnik ◽

...

Keyword(s):

Pancreatic Cancer ◽

Ct Imaging ◽

Scid Mice

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6591 The role of PET/CT imaging in patients with suspected recurrence of pancreatic cancer

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(09)71312-6 ◽

2009 ◽

Vol 7 (2) ◽

pp. 387

Author(s):

R. Epelbaum ◽

R. Bar-Shalom ◽

Z. Keidar ◽

D. Gaitini ◽

O. Israel

Keyword(s):

Pancreatic Cancer ◽

Ct Imaging ◽

Pet Ct ◽

Suspected Recurrence

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The “K-Sign”—A Novel CT Finding Suggestive before the Appearance of Pancreatic Cancer

Cancers ◽

10.3390/cancers13164222 ◽

2021 ◽

Vol 13 (16) ◽

pp. 4222

Author(s):

Yuko Kobashi ◽

Masateru Uchiyama ◽

Junichi Matsui

Keyword(s):

Pancreatic Cancer ◽

Early Diagnosis ◽

Early Stage ◽

Patient Characteristics ◽

Ct Imaging ◽

Ductal Adenocarcinoma ◽

Control Group ◽

Preoperative Ct ◽

Invasive Ductal Adenocarcinoma ◽

Ct Finding

Pancreatic invasive ductal adenocarcinoma (PDAC) has a poor prognosis, and the detection of PDAC during the early stage is thought to improve prognosis. In this study, we retrospectively investigated pancreatic morphological abnormalities that lead to the early diagnosis of PDAC with computed tomography (CT) imaging. In total, 41 out of 308 patients diagnosed with pancreatic cancer between 2011 and 2017 in our institution were enrolled. As a control group for the group with pancreatic cancer, 4277 patients without pancreato-biliary diseases were enrolled. We retrospectively reviewed and analyzed the clinical data including patient characteristics, the clinical course and preoperative CT imaging with pancreatic morphological features. Out of 41 patients, 24 patients (58.5%) showed local K-shaped constriction of the pancreatic parenchyma “K-sign” on preoperative CT images. Eight patients (19.5%) showed localized fatty change. Out of 4277 control patients, seven patients (0.16%) showed K-sign. “K-sign” may be used for the early diagnosis of PDAC by CT imaging.

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