Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer’s disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase

2015 ◽  
Vol 63 ◽  
pp. 64-71 ◽  
Author(s):  
Sadaf Riaz ◽  
Islam Ullah Khan ◽  
Marek Bajda ◽  
Muhammad Ashraf ◽  
Qurat-ul-Ain ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Type Ii Diabetes ◽  
Organic Molecule ◽  
Type Ii Diabetes Mellitus ◽  
In Vitro Studies ◽  
Type Ii ◽  
Potential Treatment

Amylin Pharmacology in Alzheimer's Disease Pathogenesis and Treatment

2021 ◽  
Vol 19 ◽  
Author(s):  
Rachel R Corrigan ◽  
Helen Piontkivska ◽  
Gemma Casadesus
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Type Ii Diabetes ◽  
Peptide Hormone ◽  
Type Ii Diabetes Mellitus ◽  
Amyloid Peptide ◽  
Type Ii ◽  
Disease Pathogenesis ◽  
Neuroprotective Effects

: The metabolic peptide hormone amylin, in concert with other metabolic peptides like insulin and leptin, has an important role in metabolic homeostasis and has been intimately linked to Alzheimer’s disease (AD). Interestingly, this pancreatic amyloid peptide is known to self-aggregate much like amyloid-beta and has been reported to be a source of pathogenesis in both Type II diabetes mellitus (T2DM) and Alzheimer’s disease. The traditional “gain of toxic function” properties assigned to amyloid proteins are however contrasted by several reports highlighting neuroprotective effects amylin and a recombinant analog, pramlintide, in the context of these two diseases. This suggests that pharmacological therapies aimed at modulating the amylin receptor may be therapeutically beneficial for AD development, as they already are for T2DMM. However, the nature of amylin receptor signaling is highly complex and not well studied in the context of CNS function. Therefore, to begin to address this pharmacological paradox in amylin research, the goal of this review is to summarize the current research on amylin signaling and CNS functions and critically address paradoxical nature of this hormone's signaling in the context of AD pathogenesis.

Bacteriophage - A Common Divergent Therapeutic Approach for Alzheimer's Disease and Type II Diabetes Mellitus

2014 ◽  
Vol 13 (3) ◽  
pp. 491-500 ◽  
Author(s):  
Sayed Sohrab ◽  
Sajjad Karim ◽  
Mohammad Kamal ◽  
Adel Abuzenadah ◽  
Adeel Chaudhary ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Type Ii Diabetes ◽  
Therapeutic Approach ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii
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