Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer’s disease therapy

2019 ◽  
Vol 91 ◽  
pp. 103205 ◽  
Author(s):  
Rim Malek ◽  
Maciej Maj ◽  
Artur Wnorowski ◽  
Krzysztof Jóźwiak ◽  
Helene Martin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Channel ◽  
Antioxidant Capacity ◽  
Channel Blockade ◽  
Calcium Channel Blockade ◽  
Disease Therapy

scholarly journals L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

2011 ◽  
Vol 41 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Thimmappa S. Anekonda ◽  
Joseph F. Quinn ◽  
Christopher Harris ◽  
Kate Frahler ◽  
Teri L. Wadsworth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Calcium Channel ◽  
Therapeutic Strategy ◽  
Channel Blockade ◽  
Calcium Channel Blockade ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power

2021 ◽  
Author(s):  
Irene Pachón-Angona ◽  
Maciej Maj ◽  
Artur Wnorowski ◽  
Helene Martin ◽  
Krzysztof Jóźwiak ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Disease ◽  
Antioxidant Effect ◽  
Cholinesterase Inhibition ◽  
Channel Blockade ◽  
Multicomponent Synthesis ◽  
Antioxidant Power ◽  
Disease Therapy ◽  
Interesting Compound

Background: Alzheimer’s disease is a chronic neurodegenerative chronic disease with a heavy social and economic impact in our developed societies, which still lacks an efficient therapy. Method: This paper describes the Hantzsch multicomponent synthesis of twelve alkyl hexahydro-quinoline-3-carboxylates, 4a–l, along with the evaluation of their Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power. Results: Compound 4l showed submicromolar inhibition of butyrylcholinesterase, Ca2+ channel antagonism and an antioxidant effect. Conclusion: Compound 4l is an interesting compound that deserves further investigation for Alzheimer’s disease therapy.

Enhanced vasodilatation in essential hypertension by calcium channel blockade with verapamil

Hypertension ◽  
1982 ◽  
Vol 4 (3) ◽  
pp. 26-31 ◽  
Author(s):  
U. L. Hulthen ◽  
P. Bolli ◽  
F. W. Amann ◽  
W. Kiowski ◽  
F. R. Buhler
Keyword(s):  
Essential Hypertension ◽  
Calcium Channel ◽  
Channel Blockade ◽  
Calcium Channel Blockade
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