Recent Advances in B-RAF Inhibitors as Anticancer Agents

2022 ◽  
pp. 105597
Author(s):  
Pathan Shahebaaz Khan ◽  
Patil Rajesh ◽  
Patil Rajendra ◽  
Manohar G. Chaskar ◽  
Arote Rohidas ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Recent Advances

Recent Advances in Development of Polyphenols as Anticancer Agents

2018 ◽  
Vol 18 (15) ◽  
pp. 1265-1269 ◽  
Author(s):  
Sreekanth Thota ◽  
Daniel Alencar Rodrigues ◽  
Eliezer J. Barreiro
Keyword(s):  
Anticancer Agents ◽  
Recent Advances

Recent Advances in the Development of Thioredoxin Reductase Inhibitors as Anticancer Agents

2012 ◽  
Vol 13 (11) ◽  
pp. 1432-1444 ◽  
Author(s):  
Yang Liu ◽  
Yijing Li ◽  
Shenghui Yu ◽  
Guisen Zhao
Keyword(s):  
Anticancer Agents ◽  
Thioredoxin Reductase ◽  
Reductase Inhibitors ◽  
Recent Advances

Recent Advances in Development of Glutaminase Inhibitors as Anticancer Agents

Yakhak Hoeji ◽  
2021 ◽  
Vol 65 (5) ◽  
pp. 344-348
Author(s):  
Gyubi Kim ◽  
Hansol Joo ◽  
Jong-Wha Jung
Keyword(s):  
Anticancer Agents ◽  
Recent Advances

Recent Advances in the New Generation Taxane Anticancer Agents

ChemInform ◽  
2005 ◽  
Vol 36 (51) ◽  
Author(s):  
R. Geney ◽  
J. Chen ◽  
I. Ojima
Keyword(s):  
Anticancer Agents ◽  
Recent Advances ◽  
New Generation

Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy

2019 ◽  
pp. 91-123
Author(s):  
Dharambir Kashyap ◽  
Hardeep Singh Tuli ◽  
Mukerrem Betul Yerer ◽  
Anil K. Sharma ◽  
Harpal Singh Buttar ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Current Trends ◽  
Recent Advances

scholarly journals Recent Advances in the Development of PI3K/mTOR-Based Anticancer Agents: A Mini Review

Folia Medica ◽  
2021 ◽  
Vol 63 (1) ◽  
pp. 7-14
Author(s):  
Ishan Panchal ◽  
Archana Navale ◽  
Ashish Shah ◽  
Sandip Badeliya ◽  
Rati Tripathi
Keyword(s):  
Clinical Trials ◽  
Anticancer Agents ◽  
Mammalian Target Of Rapamycin ◽  
The Body ◽  
Target Of Rapamycin ◽  
Selective Inhibitors ◽  
Intensive Research ◽  
Recent Advances ◽  
Comprehensive Information ◽  
Abnormal Cells

Cancer refers to the group of diseases characterized by uncontrolled growth of abnormal cells. It spreads throughout the body which makes this disease one of the huge global threats to mankind. Intensive research over the years has established deregulation of mam-malian target of rapamycin pathway in cancer. This has led to the development of mammalian target of rapamycin inhibitors. Several inhibitors of the mammalian target of rapamycin are under preclinical and early clinical trials. Researchers have investigated a series of furoquinoline, phenyl sulphonylureas, 4-acrylamido-quinoline, pyrazolochalcones, imidazole [4,5-b] pyridine, thienopyrimidine, aminopyrimidin scaffolds in the last three years. This review provides comprehensive information and critical discussions on designing of novel selective inhibitors of mammalian target of rapamycin with superior activity in the treatment of cancer. 

scholarly journals Pyrrole as an Important Scaffold of Anticancer Drugs: Recent Advances

2022 ◽  
Vol 25 ◽  
pp. 24-40
Author(s):  
Emilio Mateev ◽  
Maya Georgieva ◽  
Alexander Zlatkov
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Tyrosine Kinases ◽  
Lipid Lowering ◽  
Pyrrole Derivatives ◽  
Design And Synthesis ◽  
Anticancer Properties ◽  
Highly Active ◽  
Recent Advances ◽  
Cytochrome P450 Family

With the significant increase of patients suffering from different types of cancer, it is evident that prompt measures in the development of novel and effective agents need to be taken. Pyrrole moiety has been found in various active compounds with anti-inflammatory, antiseptic, antibacterial, lipid-lowering and anticancer properties. Recent advances in the exploration of highly active and selective cytotoxic structures containing pyrrole motifs have shown promising data for future investigations. Accordingly, this review presents an overview of recent developments in the pyrrole derivatives as anticancer agents, with a main focus towards the key moieties required for the anti-tumor activities. Pyrrole molecules comprising prominent targeting capacities against microtubule polymerization, tyrosine kinases, cytochrome p450 family 1, histone deacetylase and bcl-2 proteins were reported. In addition, several mechanisms of action, such as apoptosis, cell cycle arrest, inhibiting kinases, angiogenesis, disruption of cell migration, modulation of nuclear receptor responsiveness and others were analyzed. Furthermore, in most of the discussed cases we provided synthesis schemes of the mentioned molecules. Overall, the utilization of pyrrole scaffold for the design and synthesis of novel anticancer drugs could be a promising approach for future investigations.  

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