Recent Advances in the Synthesis of α-Hydroxy-β-Amino Acids and Their Use in the SAR Studies of Taxane Anticancer Agents

: Podophyllotoxins including epipodophyllotoxin derivatives can act on a diverse array of drug targets in cancer cells, and thus possess potential activity against various forms of cancer cell lines including drug-resistant forms. Moreover, several podophyllotoxin derivatives which are represented by etoposide and teniposide have already been approved for the cancer therapy, demonstrating podophyllotoxin moiety is a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.

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Recent Advances in Development of Polyphenols as Anticancer Agents

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557518666180220122113 ◽

2018 ◽

Vol 18 (15) ◽

pp. 1265-1269 ◽

Cited By ~ 7

Author(s):

Sreekanth Thota ◽

Daniel Alencar Rodrigues ◽

Eliezer J. Barreiro

Keyword(s):

Anticancer Agents ◽

Recent Advances

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Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520614666141128121812 ◽

2015 ◽

Vol 15 (5) ◽

pp. 537-547 ◽

Cited By ~ 32

Author(s):

Mingming Zhang ◽

Dianqing Sun

Keyword(s):

Anticancer Agents ◽

Recent Advances ◽

Natural And Synthetic

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Structural Insights of Oxindole based Kinase Inhibitors as Anticancer Agents: Recent Advances

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113334 ◽

2021 ◽

pp. 113334

Author(s):

Prajwal Dhokne ◽

Akash P. Sakla ◽

Nagula Shankaraiah

Keyword(s):

Anticancer Agents ◽

Kinase Inhibitors ◽

Recent Advances ◽

Structural Insights

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Recent Advances in Rapid Synthesis of Non-proteinogenic Amino Acids from Proteinogenic Amino Acids Derivatives via Direct Photo-Mediated C–H Functionalization

Molecules ◽

10.3390/molecules25225270 ◽

2020 ◽

Vol 25 (22) ◽

pp. 5270

Author(s):

Zhenbo Yuan ◽

Xuanzhong Liu ◽

Changmei Liu ◽

Yan Zhang ◽

Yijian Rao

Keyword(s):

Amino Acids ◽

Direct Synthesis ◽

Environmentally Friendly ◽

Powerful Method ◽

Rapid Synthesis ◽

Conservation Of Energy ◽

Mild Conditions ◽

Recent Advances ◽

Recent Developments

Non-proteinogenic amino acids have attracted tremendous interest for their essential applications in the realm of biology and chemistry. Recently, rising C–H functionalization has been considered an alternative powerful method for the direct synthesis of non-proteinogenic amino acids. Meanwhile, photochemistry has become popular for its predominant advantages of mild conditions and conservation of energy. Therefore, C–H functionalization and photochemistry have been merged to synthesize diverse non-proteinogenic amino acids in a mild and environmentally friendly way. In this review, the recent developments in the photo-mediated C–H functionalization of proteinogenic amino acids derivatives for the rapid synthesis of versatile non-proteinogenic amino acids are presented. Moreover, postulated mechanisms are also described wherever needed.

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Recent Advances in the Development of Thioredoxin Reductase Inhibitors as Anticancer Agents

Current Drug Targets ◽

10.2174/138945012803530224 ◽

2012 ◽

Vol 13 (11) ◽

pp. 1432-1444 ◽

Cited By ~ 30

Author(s):

Yang Liu ◽

Yijing Li ◽

Shenghui Yu ◽

Guisen Zhao

Keyword(s):

Anticancer Agents ◽

Thioredoxin Reductase ◽

Reductase Inhibitors ◽

Recent Advances

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QSAR Studies to Predict Activity of HSP90 Inhibitors

Current Topics in Medicinal Chemistry ◽

10.2174/1568026621666211011095858 ◽

2021 ◽

Vol 21 ◽

Author(s):

Vaishali M. Patil ◽

Neeraj Masand ◽

Satya P. Gupta ◽

Brian S. J. Blagg

Keyword(s):

Anticancer Agents ◽

Heat Shock Protein 90 ◽

New Drugs ◽

Signaling Proteins ◽

Hsp90 Inhibitors ◽

Oncogenic Signaling ◽

Qsar Studies ◽

Sar Studies ◽

Promising Target ◽

Qsar Models

: Heat shock protein 90 (HSP90) is a multichaperone complex that mediates the maturation and stability of a variety of oncogenic signaling proteins. HSP90 has emerged as a promising target for the development of anticancer agents. Heterocyclic chemical moieties with HSP90 inhibitory activity were studied continuously during the last decades, and resulting data were applied by medicinal chemists to design and develop new drugs. Their structure-activity relationship (SAR) studies and QSAR models have been derived to assist the current drug development process. The QSAR models are obtained via multiple linear regression (MLR) and non-linear approaches. Interpretation of the reported model highlights the core template required to design novel, potent HSP90 inhibitors to be used as anticancer agents.

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